Search Results - "Naguib, F N"

Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii by EL KOUNI, M. H, GUARCELLO, V, AL SAFARJALANI, O. N, NAGUIB, F. N. M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Uridine phosphorylase from Schistosoma mansoni by el Kouni, M H, Naguib, F N, Niedzwicki, J G, Iltzsch, M H, Cha, S

“…Uridine phosphorylase is the only pyrimidine nucleoside cleaving activity that can be detected in extracts of Schistosoma mansoni. The enzyme is distinct from…”
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Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases : implications for chemotherapy with 5-fluoropyrimidines by EL KOUNI, M. H, EL KOUNI, M. M, NAGUIB, F. N. M

“…Enzyme inhibition studies on extracts from human liver, mouse liver, and human placenta indicate that there are considerable differences between human and…”
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Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition by Guerin, David J., Mazeas, Daniel, Musale, Manoj S., Naguib, Fardos N.M., Al Safarjalani, Omar N., el Kouni, Mahmoud H., Panzica, Raymond P.

“…5-( o-Benzyloxy)benzylbarbituric acid ( 6) and 5-( p-benzyloxy)benzylbarbituric acid ( 7) were prepared and their inhibitory activities compared to 5-(…”
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Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase by el Kouni, M H, Naguib, F N, Chu, S H, Cha, S M, Ueda, T, Gosselin, G, Imbach, J L, Shealy, Y F, Otter, B A

“…Several arabinosyl-, xylosyl-, lyxosyl, 5'-deoxy-, acyclo-, 2,2'-anhydro-, 2,3'-anhydro-2'-deoxy-, 2,5'-anhydro-, 6,5'-cyclo-, and carbocyclic analogues of…”
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5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase by Naguib, F N, Levesque, D L, Wang, E C, Panzica, R P, el Kouni, M H

“…5-Benzylbarbituric acid derivatives were synthesized as a series of new, specific, and potent inhibitors of uridine phosphorylase. Among these,…”
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5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase by el Kouni, Mahmoud H, Goudgaon, Naganna M, Rafeeq, Mohammad, Al Safarjalani, Omar N, Schinazi, Raymond F, Naguib, Fardos N.M

“…5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine…”
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Enzymes of uracil catabolism in normal and neoplastic human tissues by NAGUIB, F. N. M, EL KOUNI, M. H, SUNGMAN CHA

“…Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta-ureidopropionase (EC 3.5.1.6)…”
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Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- O-acetyluridine, a prodrug of uridine by Ashour, Osama M, Naguib, Fardos N.M, Panzica, Raymond P, Al Safarjalani, Omar N, el Kouni, Mahmoud H

“…Administration of 200 mg/kg of 5-fluorouracil (FUra) to mice bearing human colon carcinoma DLD-1 xenografts resulted in 100% mortality. Oral administration of…”
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Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii by NAGUIB, F. N. M, ILTZSCH, M. H, EL KOUNI, M. M, PANZICA, R. P, EL KOUNI, M. H

“…Preliminary characterization of Toxoplasma gondii phosphoribosyltransferase activity towards purine nucleobases indicates that there are at least two enzymes…”
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Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase : relevance to chemotherapy by ASHOUR, O. M, AL SAFARJALANI, O. N, NAGUIB, F. N. M, GOUDGAON, N. M, SCHINAZI, R. F, EL KOUNI, M. H

“…The purpose of this investigation was to evaluate the efficacy of oral 5-(phenylselenenyl)-acyclouridine (PSAU) in increasing endogenous plasma uridine…”
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Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii by el Kouni, Mahmoud H., Naguib, Fardos N.M., Panzica, Raymond P., Otter, Brian A., Chu, Shih-Hsi, Gosselin, Gilles, Chu, Chung K., Schinazi, Raymond F., Shealy, Y.Fulmer, Goudgaon, Naganna, Ozerov, Alexander A., Ueda, Tohru, Iltzsch, Max H.

“…One hundred and fifty analogues of uridine, with various modifications to the uracil and pentose moieties, have been tested and compared with uridine with…”
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Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10 by Ashour, Osama M, Naguib, Fardos N.M, Goudgaon, Naganna M, Schinazi, Raymond F, el Kouni, Mahmoud H

“…The effect of co-administration of 5-(phenylselenenyl)acyclouridine (PSAU), a new uridine phosphorylase (UrdPase, EC 2.4.2.3) inhibitor, on the efficacy of…”
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Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2', 3', 5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy by ASHOUR, O. M, NAGUIB, F. N. M, GOUDGAON, N. M, SCHINAZI, R. F, EL KOUNI, M. H

“…The purpose of this investigation was to study the effects of combining oral 5-(phenylselenenyl)acyclouridine (PSAU) with 2',3',5'-tri-O-acetyluridine (TAU) on…”
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5-( m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration : Implications for chemotherapy by Ashour, Osama M., Naguib, Fardos N.M., el Kouni, Mahmoud H.

“…5-( m-Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA), the most potent inhibitor known of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme…”
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Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside by ASHOUR, O. M, NAGUIB, F. N. M, KHALIFA, M. M. A, ABDEL-RAHEEM, M. H, PANZICA, R. P, EL KOUNI, M. H

“…5-(Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA) was recently synthesized as a potent and specific inhibitor of uridine phosphorylase (EC 2.4.2.3),…”
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Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5-benzyloxybenzyluracil by NAGUIB, F. N. M, SHAO-NAN HAO, EL KOUNI, M. H

“…5-Benzyloxybenzyluracil (BBU) is the most potent inhibitor (Ki approximately 30 nM) of dihydrouracil dehydrogenase (EC 1.3.1.2), the first enzyme in the…”
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Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice by el Kouni, M H, Naguib, F N, Park, K S, Cha, S, Darnowski, J W, Soong, S J

“…The activity of hepatic uridine phosphorylase (EC 2.4.2.3.) in male mice (24-29 g) maintained in standardized conditions of 12 hr light (0600-1800 hr)…”
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Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver by Naguib, F N, el Kouni, M H, Cha, S

“…One hundred and five nucleobase analogues were screened as inhibitors of dihydrouracil dehydrogenase (DHUDase, EC 1.3.1.2) from mouse liver…”
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Pyrimidine salvage pathways in adult Schistosoma mansoni by el Kouni, M H, Naguib, F N

“…Adult Schistosoma mansoni can utilize radiolabelled cytidine, uridine, uracil, orotate, deoxycytidine and thymidine for the synthesis of its nucleic acids. In…”
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