Search Results - "Nagtegaal, Iris D"

What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer? by NAGTEGAAL, Iris D, QUIRKE, Phil

“…Treatment of rectal cancer has changed dramatically over the last decade. The worldwide introduction of total mesorectal excision in combination with the…”
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Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands by Dinmohamed, Avinash G, Visser, Otto, Verhoeven, Rob H A, Louwman, Marieke W J, van Nederveen, Francien H, Willems, Stefan M, Merkx, Matthias A W, Lemmens, Valery E P P, Nagtegaal, Iris D, Siesling, Sabine

“…[...]hospitals might have postponed diagnostic evaluation or have longer turnaround times for diagnostic evaluation because many hospital-based resources are…”
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Tumor Deposits in Colorectal Cancer: Improving the Value of Modern Staging-A Systematic Review and Meta-Analysis by Nagtegaal, Iris D, Knijn, Nikki, Hugen, Niek, Marshall, Helen C, Sugihara, Kenichi, Tot, Tibor, Ueno, Hideki, Quirke, Philip

“…Purpose Colorectal cancer (CRC) treatment is largely determined by tumor stage. Despite improvements made in the treatment of various types of metastatic…”
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Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies by Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam

“…To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal…”
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Pathways of spread in rectal cancer: a reappraisal of the true routes to distant metastatic disease by Lord, Amy C., Knijn, Nikki, Brown, Gina, Nagtegaal, Iris D.

“…Rectal cancer can spread in a number of ways which have been previously recognised and validated as prognostic markers. These routes of spread are not…”
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Has the new TNM classification for colorectal cancer improved care? by Nagtegaal, Iris D, Quirke, Phil, Schmoll, Hans-Joachim

“…Since the issue of the seventh edition of the TNM classification guidelines for colorectal cancer there has been discussion about some of the associated…”
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Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial by van Gijn, Willem, MD, Marijnen, Corrie AM, Prof, Nagtegaal, Iris D, MD, Kranenbarg, Elma Meershoek-Klein, MSc, Putter, Hein, Prof, Wiggers, Theo, Prof, Rutten, Harm JT, MD, Påhlman, Lars, Prof, Glimelius, Bengt, Prof, van de Velde, Cornelis JH, Prof

“…Summary Background The TME trial investigated the value of preoperative short-term radiotherapy in combination with total mesorectal excision (TME). Long-term…”
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Multimodal CEA-targeted fluorescence and radioguided cytoreductive surgery for peritoneal metastases of colorectal origin by de Gooyer, Jan Marie, Elekonawo, Fortuné M. K., Bremers, Andreas J. A., Boerman, Otto C., Aarntzen, Erik H. J. G., de Reuver, Philip R., Nagtegaal, Iris. D., Rijpkema, Mark, de Wilt, Johannes H. W.

“…In patients with colorectal peritoneal metastases scheduled for cytoreductive surgery, accurate preoperative estimation of tumor burden and subsequent…”
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The impact of the temporary suspension of national cancer screening programmes due to the COVID-19 epidemic on the diagnosis of breast and colorectal cancer in the Netherlands by Dinmohamed, Avinash G, Cellamare, Matteo, Visser, Otto, de Munck, Linda, Elferink, Marloes A G, Westenend, Pieter J, Wesseling, Jelle, Broeders, Mireille J M, Kuipers, Ernst J, Merkx, Matthias A W, Nagtegaal, Iris D, Siesling, Sabine

“…Oncological care was largely derailed due to the reprioritisation of health care services to handle the initial surge of COVID-19 patients adequately. Cancer…”
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Impact of COVID-19 and suspension of colorectal cancer screening on incidence and stage distribution of colorectal cancers in the Netherlands by Toes-Zoutendijk, Esther, Vink, Geraldine, Nagtegaal, Iris D., Spaander, Manon C.W., Dekker, Evelien, van Leerdam, Monique E., Siesling, Sabine, Lansdorp-Vogelaar, Iris, Elferink, Marloes A.G.

“…Many countries had to suspend their colorectal cancer (CRC) screening programme as a result of the COVID-19 pandemic. This eventually may lead to postponed…”
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Somatic Mutations in MLH1 and MSH2 Are a Frequent Cause of Mismatch-Repair Deficiency in Lynch Syndrome-Like Tumors by Mensenkamp, Arjen R, Vogelaar, Ingrid P, van Zelst–Stams, Wendy A.G, Goossens, Monique, Ouchene, Hicham, Hendriks–Cornelissen, Sandra J.B, Kwint, Michael P, Hoogerbrugge, Nicoline, Nagtegaal, Iris D, Ligtenberg, Marjolijn J.L

“…Lynch syndrome is caused by germline mutations in the mismatch repair (MMR) genes. Tumors are characterized by microsatellite instability (MSI). However, a…”
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Adjuvant Tamoxifen Reduces Subsequent Breast Cancer in Women With Estrogen Receptor–Positive Ductal Carcinoma in Situ: A Study Based on NSABP Protocol B-24 by CRAIG ALLRED, D, ANDERSON, Stewart J, LAND, Stephanie R, WOLMARK, Norman, PAIK, Soonmyung, LAWRENCE WICKERHAM, D, NAGTEGAAL, Iris D, SWAIN, Sandra M, MAMOUNAS, Elefetherios P, JULIAN, Thomas B, GEYER, Charles E, COSTANTINO, Joseph P

“…The NSABP (National Surgical Adjuvant Breast and Bowel Project) B-24 study demonstrated significant benefit with adjuvant tamoxifen in patients with ductal…”
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Deep learning for multi-class semantic segmentation enables colorectal cancer detection and classification in digital pathology images by Bokhorst, John-Melle, Nagtegaal, Iris D., Fraggetta, Filippo, Vatrano, Simona, Mesker, Wilma, Vieth, Michael, van der Laak, Jeroen, Ciompi, Francesco

“…In colorectal cancer (CRC), artificial intelligence (AI) can alleviate the laborious task of characterization and reporting on resected biopsies, including…”
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Polyp size of 1 cm is insufficient to discriminate neoplastic and non-neoplastic gallbladder polyps by Wennmacker, Sarah Z., van Dijk, Aafke H., Raessens, Joris H. J., van Laarhoven, Cornelis J. H. M., Drenth, Joost P. H., de Reuver, Philip R., Nagtegaal, Iris D.

“…Background A significant proportion of gallbladder polyps are non-neoplastic, for which resection is not necessary. However, international guidelines advocate…”
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Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry by Trinh, Anne, Trumpi, Kari, De Sousa E Melo, Felipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Kuppen, Peter J K, Reimers, Marlies S, Swets, Marloes, Koopman, Miriam, Nagtegaal, Iris D, Jansen, Marnix, Hooijer, Gerrit K J, Offerhaus, George J A, Kranenburg, Onno, Punt, Cornelis J, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Recent transcriptomic analyses have identified four distinct molecular subtypes of colorectal cancer with evident clinical relevance. However, the requirement…”
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Colorectal signet‐ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor by Hugen, Niek, Verhoeven, Rob H., Lemmens, Valery E, van Aart, Carola J., Elferink, Marloes A., Radema, Sandra A., Nagtegaal, Iris D., de Wilt, Johannes H.

“…Colorectal signet‐ring cell carcinoma (SRCC) has been associated with poor survival compared with mucinous adenocarcinoma (MC) and the more common…”
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Tumor deposits in colorectal cancer: Refining their definition in the TNM system by Ueno, Hideki, Nagtegaal, Iris D., Quirke, Philip, Sugihara, Kenichi, Ajioka, Yoichi

“…Tumor deposits (TDs) are discontinuous tumor spread in the mesocolon/mesorectum which is found in approximately 20% of colorectal cancer (CRC) and negatively…”
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Umbilical metastases: Real‐world data shows abysmal outcome by Hugen, Niek, Kanne, Heleen, Simmer, Femke, Water, Carlijn, Voorham, Quirinus J., Ho, Vincent K., Lemmens, Valery E., Simons, Michiel, Nagtegaal, Iris D.

“…Umbilical metastases form a clinical challenge, especially when they represent the first sign of malignant disease and the primary tumor is unknown. Our study…”
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Can extranodal tumour deposits be diagnosed on MRI? Protocol for a multicentre clinical trial (the COMET trial) by Lord, Amy C, Moran, Brendan, Abulafi, Muti, Rasheed, Shahnawaz, Nagtegaal, Iris D, Terlizzo, Monica, Brown, Gina

“…IntroductionTumour deposits (TDs) are a poor prognostic marker when seen on pathology, and are worse than lymph node metastases (LNMs). They are now being…”
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Clinical lymph node staging in colorectal cancer; a flip of the coin? by Brouwer, Nelleke P.M., Stijns, Rutger C.H., Lemmens, Valery E.P.P., Nagtegaal, Iris D., Beets-Tan, Regina G.H., Fütterer, Jurgen J., Tanis, Pieter J., Verhoeven, Rob H.A., de Wilt, Johannes H.W.

“…This study aims to provide insight in the quality of current daily practice in clinical lymph node staging in colorectal cancer (CRC) in the Netherlands. Data…”
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