Search Results - "Nagorski, Richard W"

Utilization of Cofactor Binding Energy for Enzyme Catalysis: Formate Dehydrogenase-Catalyzed Reactions of the Whole NAD Cofactor and Cofactor Pieces by Cristobal, Judith R., Nagorski, Richard W., Richard, John P.

“…The pressure to optimize enzymatic rate accelerations has driven the evolution of the induced-fit mechanism for enzyme catalysts where the binding interactions…”
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Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions by Fernandez, Patrick L, Nagorski, Richard W, Cristobal, Judith R, Amyes, Tina L, Richard, John P

“…The activation barriers ΔG ⧧ for k cat/K m for the reactions of whole substrates catalyzed by 6-phosphogluconate dehydrogenase, glucose 6-phosphate…”
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N‑(Hydroxybenzyl)benzamide Derivatives: Aqueous pH-Dependent Kinetics and Mechanistic Implications for the Aqueous Reactivity of Carbinolamides by Koyanagi, Takaoki, Siena, Paul M, Przybyla, David E, Rafie, Mohammad I, Nagorski, Richard W

“…The rate constants for the aqueous reaction, between pH 0 and 14, have been determined for a series of amide substituted N-(hydroxybenzyl)­benzamide…”
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Determination of the pK a of Cyclobutanone: Brønsted Correlation of the General Base-Catalyzed Enolization in Aqueous Solution and the Effect of Ring Strain by Cope, Steven M, Tailor, Dishant, Nagorski, Richard W

“…The induction of strain in carbocycles, thereby increasing the amount of s-character in the C−H bonds and the acidity of these protons, has been probed with…”
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Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis by Sansone, Matthew F., Koyanagi, Takaoki, Przybyla, David E., Nagorski, Richard W.

“…A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed…”
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Amidates as Leaving Groups:  Structure/Reactivity Correlation of the Hydroxide-Dependent E1cB-like Breakdown of Carbinolamides in Aqueous Solution by Tenn, William J, Murphy, John L, Bim-Merle, Jessica K, Brown, Jason A, Junia, Adam J, Price, Malea A, Nagorski, Richard W

“…The kinetic study of the aqueous reaction, between pH 10 and 14, of eight N-(hydroxymethyl)benzamide derivatives in water at 25 °C, I = 1.0 M (KCl), has been…”
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Ring Strain and Its Effect on the Rate of the General-Base Catalyzed Enolization of Cyclobutanone by Cantlin, Ryan J, Drake, James, Nagorski, Richard W

“…The 3-quinuclidinone-catalyzed (pK BH = 7.5) enolization of cyclobutanone (1) in D2O at 25 °C, I = 1.0 (KCl) was followed by deuterium incorporation, which was…”
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Carbinol Derivatives of N‐(α‐Hydroxybenzyl)benzamide: Acid and Base‐Dependent Kinetics in Water and the Mechanistic Implications for Carbinolamide Reactivity by Tyminski, Kurt S., Stewart, Sarah C., Nagorski, Richard W.

“…The kinetics of the aqueous reaction, between pH values of 0–4 & 7–14, have been determined for a series of carbinol substituted N‐(α‐hydroxybenzyl)benzamide…”
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Kinetic Dependence of the Aqueous Reaction of N-(Hydroxymethyl)benzamide Derivatives upon Addition of Electron-Withdrawing Groups by Tenn, William J, French, Nina L, Nagorski, Richard W

“…The rate constants for the hydronium ion, hydroxide, and water-catalyzed breakdown of N-(hydroxymethyl)benzamide (1), 4-chloro-N-(hydroxymethyl)benzamide (2),…”
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Determination of the p K a of Cyclobutanone: Brønsted Correlation of the General Base-Catalyzed Enolization in Aqueous Solution and the Effect of Ring Strain by Cope, Steven M., Tailor, Dishant, Nagorski, Richard W.

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Determination of the pKa of Cyclobutanone: Brønsted Correlation of the General Base-Catalyzed Enolization in Aqueous Solution and the Effect of Ring Strain by COPE, Steven M, TAILOR, Dishant, NAGORSKI, Richard W

“…The induction of strain in carbocycles, thereby increasing the amount of s-character in the C-H bonds and the acidity of these protons, has been probed with…”
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Rate of formation of N-(hydroxymethyl)benzamide derivatives in water as a function of pH and their equilibrium constants by Ankem, Ramana V., Murphy, John L., Nagorski, Richard W.

“…The third-order rate constants for the pH-dependent formation of the carbinolamides generated from the reaction of formaldehyde and benzamide, 4-chloro,…”
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Rapid amidic hydrolysis: a competitive reaction pathway under basic conditions for N-(hydroxymethyl)benzamide derivatives bearing electron-donating groups by Murphy, John L., Tenn, William J., Labuda, Joseph J., Nagorski, Richard W.

“…Studies of N-(hydroxymethyl)benzamide derivatives have concluded that the hydroxide-dependent reaction occurs via a specific-base catalyzed deprotonation of…”
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General-buffer catalysis of the reaction of N-(hydroxymethyl)benzamide: a new pathway for the aqueous reaction of carbinolamides by Mennenga, Amanda G., Johnson, Amy L., Nagorski, Richard W.

“…[Display omitted] The second-order rate constants for the general-buffer catalyzed breakdown of N-(hydroxymethyl)benzamide ( 1 ) in water at 25 °C, I = 1.0…”
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The Reversible Formation of the Enolate of Benzocyclobutenone under Aqueous Conditions by Nagorski, Richard W., DeAtley, April D., Broadus, Katherine M.

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