Search Results - "Nagorsen, Dirk"

Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy by Khaldoyanidi, Sophia, Nagorsen, Dirk, Stein, Anthony, Ossenkoppele, Gerrit, Subklewe, Marion

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Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia by Kantarjian, Hagop, Stein, Anthony, Gökbuget, Nicola, Fielding, Adele K, Schuh, Andre C, Ribera, Josep-Maria, Wei, Andrew, Dombret, Hervé, Foà, Robin, Bassan, Renato, Arslan, Önder, Sanz, Miguel A, Bergeron, Julie, Demirkan, Fatih, Lech-Maranda, Ewa, Rambaldi, Alessandro, Thomas, Xavier, Horst, Heinz-August, Brüggemann, Monika, Klapper, Wolfram, Wood, Brent L, Fleishman, Alex, Nagorsen, Dirk, Holland, Christopher, Zimmerman, Zachary, Topp, Max S

“…Among adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia, treatment with the bispecific anti-CD19 and anti-CD3 monoclonal…”
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First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors by Papadopoulos, Kyriakos P, Gluck, Larry, Martin, Lainie P, Olszanski, Anthony J, Tolcher, Anthony W, Ngarmchamnanrith, Gataree, Rasmussen, Erik, Amore, Benny M, Nagorsen, Dirk, Hill, John S, Stephenson, Jr, Joe

“…Binding of colony-stimulating factor 1 (CSF1) ligand to the CSF1 receptor (CSF1R) regulates survival of tumor-associated macrophages, which generally promote…”
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Utilizing the BiTE (bispecific T-cell engager) platform for immunotherapy of cancer by Stieglmaier, Julia, Benjamin, Jonathan, Nagorsen, Dirk

“…Various approaches of T-cell-based cancer immunotherapy are currently under investigation, among these are BiTE® (bispecific T-cell engager) antibody…”
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Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival by TOPP, Max S, KUFER, Peter, STELLJES, Matthias, SCHAICH, Markus, DEGENHARD, Evelyn, KÖHNE-VOLLAND, Rudolf, BRÜGGEMANN, Monika, OTTMANN, Oliver, PFEIFER, Heike, BURMEISTER, Thomas, NAGORSEN, Dirk, SCHMIDT, Margit, GÖKBUGET, Nicola, LUTTERBUESE, Ralf, REINHARDT, Carsten, BAEUERLE, Patrick A, KNEBA, Michael, EINSELE, Hermann, RIETHMÜLLER, Gert, HOELZER, Dieter, ZUGMAIER, Gerhard, BARGOU, Ralf C, GOEBELER, Mariele, KLINGER, Matthias, NEUMANN, Svenja, HORST, Heinz-A, RAFF, Thorsten, VIARDOT, Andreas, SCHMID, Mathias

“…Blinatumomab, a bispecific single-chain antibody targeting the CD19 antigen, is a member of a novel class of antibodies that redirect T cells for selective…”
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Unleashing the clinical power of T cells: CD19/CD3 bi-specific T cell engager (BiTE®) antibody construct blinatumomab as a potential therapy by Zimmerman, Zachary, Maniar, Tapan, Nagorsen, Dirk

“…Multi-agent chemotherapy is the standard treatment for most B cell malignancies. Since chemotherapy can be associated with significant toxicity and since…”
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Clinical and Immunologic Responses to Active Specific Cancer Vaccines in Human Colorectal Cancer by NAGORSEN, Dirk, THIEL, Eckhard

“…Colorectal cancer is a common malignant disease, which, despite some progress, still requires improved therapeutic options. Several clinical studies have used…”
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Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells by Wong, Ryan, Pepper, Chris, Brennan, Paul, Nagorsen, Dirk, Man, Stephen, Fegan, Chris

“…Chronic lymphocytic leukemia is an incurable B-cell malignancy that is associated with tumor cell-mediated T-cell dysfunction. It therefore represents a…”
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A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics by Meyer, Miriam, Mahr, Andrea, Brewer, Joanna, Daniel, Volker, Dell‘Aringa, Justine, Goldstone, Tony, Hersey, Sarah, Johnston, Ian, Larson, Pamela, Loveridge, Michael, MacBeath, Gavin, Moyer, Mark, Nagorsen, Dirk, Papa, Sophie, Peiser, Leanne, Ranade, Koustubh, Rizzi, Ruben, Roers, Axel, Schendel, Dolores, Sivakumar, Pallavur, Tran, Eric, Türeci, Özlem, Weigand, Luise, Wennborg, Anders, Williams, Dennis, Yee, Cassian, Britten, Cedrik M.

“…Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA alleles as well as companion…”
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Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival by Nagorsen, Dirk, Voigt, Sabine, Berg, Erika, Stein, Harald, Thiel, Eckhard, Loddenkemper, Christoph

“…Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation…”
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Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors by Razak, Albiruni RA, Cleary, James M, Moreno, Victor, Boyer, Michael, Calvo Aller, Emiliano, Edenfield, William, Tie, Jeanne, Harvey, R Donald, Rutten, Annemie, Shah, Manish A, Olszanski, Anthony J, Jäger, Dirk, Lakhani, Nehal, Ryan, David P, Rasmussen, Erik, Juan, Gloria, Wong, Hansen, Soman, Neelesh, Smit, Marie-Anne Damiette, Nagorsen, Dirk, Papadopoulos, Kyriakos P

“…BackgroundTo determine the safety and efficacy of the anti-colony-stimulating factor 1 receptor (anti-CSF1R) monoclonal antibody AMG 820 in combination with…”
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Natural T Cell Immunity against Cancer by NAGORSEN, Dirk, SCHEIBENBOGEN, Carmen, MARINCOLA, Francesco M, LETSCH, Anne, KEILHOLZ, Ulrich

“…It has long been a matter of debate whether tumors are spontaneously immunogenic in patients. With the availability of sensitive methods, naturally occurring T…”
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In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer by Loddenkemper, Christoph, Schernus, Martin, Noutsias, Michel, Stein, Harald, Thiel, Eckhard, Nagorsen, Dirk

“…The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are…”
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Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer by Loddenkemper, Christoph, Hoffmann, Corinna, Stanke, Jonas, Nagorsen, Dirk, Baron, Udo, Olek, Sven, Huehn, Jochen, Ritz, Joerg‐Peter, Stein, Harald, Kaufmann, Andreas M., Schneider, Achim, Cichon, Günter

“…Regulatory (FOXP3+) T cells (Tregs) comprise a subpopulation of CD4+ T cells that suppress autoreactive immune cells, thereby protecting organs and tissues…”
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Molecular response with blinatumomab in relapsed/refractory B-cell precursor acute lymphoblastic leukemia by Gökbuget, Nicola, Kantarjian, Hagop M., Brüggemann, Monika, Stein, Anthony S., Bargou, Ralf C., Dombret, Hervé, Fielding, Adele K., Heffner, Leonard, Rigal-Huguet, Françoise, Litzow, Mark, O'Brien, Susan, Zugmaier, Gerhard, Gao, Shan, Nagorsen, Dirk, Forman, Stephen J., Topp, Max S.

“…Minimal residual disease (MRD), where leukemic cell levels are lower than the morphologic detection threshold, is the most important prognostic factor for…”
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HLA typing demands for peptide-based anti-cancer vaccine by NAGORSEN, Dirk, THIEL, Eckhard

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Relative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations by Ochsenreither, Sebastian, Fusi, Alberto, Busse, Antonia, Nagorsen, Dirk, Schrama, David, Becker, Jürgen, Thiel, Eckhard, Keilholz, Ulrich

“…Quantification of T-cell receptor (TCR) chain families can be utilized for detection of clonal T-cell populations. Besides southern blotting and antibody-based…”
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Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients by Ochsenreither, Sebastian, Fusi, Alberto, Wojtke, Susanne, Busse, Antonia, Nüssler, Natascha C, Thiel, Eckhard, Keilholz, Ulrich, Nagorsen, Dirk

“…Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of…”
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Selection and validation of endogenous reference genes using a high throughput approach by Jin, Ping, Zhao, Yingdong, Ngalame, Yvonne, Panelli, Monica C, Nagorsen, Dirk, Monsurró, Vladia, Smith, Kina, Hu, Nan, Su, Hua, Taylor, Phil R, Marincola, Francesco M, Wang, Ena

“…Endogenous reference genes are commonly used to normalize expression levels of other genes with the assumption that the expression of the former is constant in…”
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Active-specific immunization against melanoma: Is the problem at the receiving end? by Monsurrò, Vladia, Wang, Ena, Panelli, Monica C, Nagorsen, Dirk, Jin, Ping, Katia, Zavaglia, Smith, Kina, Ngalame, Yvonne, Even, Jos, Marincola, Francesco M

“…The recent progress in tumor immunology is a striking example of the successful application of modern biotechnology to understand the complex phenomenon of…”
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