Search Results - "Nagle, William A"

Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome by Fan, Kang, Nagle, William A

“…The heterogeneity of conditions underlying respiratory distress, whether classified clinically as acute lung injury (ALI) or the more severe acute respiratory…”
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Prompt protein glycosylation during acute heat stress by Henle, K J, Kaushal, G P, Nagle, W A, Nolen, G T

“…Constitutive patterns of protein synthesis and protein glycosylation are severely disrupted by acute heat stress. Stressed cells respond by preferential…”
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Inhibition of heat shock protein synthesis and protein glycosylation by stepdown heating by Henle, K J, Nagle, W A

“…Mammalian cells exhibit increased sensitivity to hyperthermic temperatures of 38-43 degrees C after an acute high-temperature heat shock; this phenomenon is…”
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Characterization of a cisplatin-resistant subline of murine RIF-1 cells and reversal of drug resistance by hyperthermia by ALI MANSOURI, HENLE, K. J, BENSON, A. M, MOSS, A. J, NAGLE, W. A

“…The development of tumor cell drug resistance is a major obstacle which often leads to failure of cancer chemotherapy. Therefore, reversing the cell drug…”
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Immunochemical quantitation of DNA adducts derived from the human bladder carcinogen 4-aminobiphenyl by ROBERTS, D. W, WAYNE BENSON, R, GROOPMAN, J. D, FLAMMANG, T. J, NAGLE, W. A, MOSS, A. J, KADLUBAR, F. F

“…To assess target-tissue exposure to the human urinary bladder carcinogen 4-aminobiphenyl (ABP), we have developed a sensitive immunochemical method for…”
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Enhanced glycosylation of a 50 kD protein during development of thermotolerance in CHO cells by Henle, K J, Nagle, W A, Norris, J S, Moss, A J

“…During the development of thermotolerance, Chinese hamster ovary cells not only synthesized classical heat shock proteins, but also incorporated [3H]D-glucose…”
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In-vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells by Elliott, Gary T, Nagle, William A, Kelly, Ken F, McCollough, David, Bona, Robert L, Burns, E. Robert

“…Two previously synthesized and two structurally novel thiazoline iron chelators are described. N4-Benzyl-N1,N8-bis[[2-(2-hydroxyphenyl)thiazolin-4-yl]carbonyl]…”
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Cytotoxicity of hyperthermia combined with bleomycin or cis-platinum in cultured RIF cells: modification by thermotolerance and by polyhydroxy compounds by NEILAN, B. A, HENLE, K. J, NAGLE, W. A, MOSS, A. J

“…The effect of thermotolerance and of polyhydroxy compounds on the cytotoxicity of bleomycin and cis-platinum was studied in cultured RIF tumor cells. Cell…”
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Molecular Nature of Mammalian Cell DNA in Alkaline Sucrose Gradients by Simpson, Joseph R., Nagle, William A., Bick, Michael D., Belli, James A.

“…Mammalian cell DNA that exhibited anomalous sedimentation in alkaline sucrose gradients was examined directly by electron microscopy. Its appearance was that…”
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Stress proteins and glycoproteins (Review) by Henle, K J, Jethmalani, S M, Nagle, W A

“…Proteins represent both structural and functional elements of biological organisms, however, their structural and catalytic function is directly linked to the…”
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Heat shock glycoprotein GP50: product of the retinoic acid-inducible J6 gene by Henle, K J, Wang, S Y, Nagle, W A, Lumpkin, C K

“…High intracellular levels of heat shock proteins and enhanced protein glycosylation are two phenomena closely associated with the cellular stress response…”
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Cultured Chinese hamster cells undergo apoptosis after exposure to cold but nonfreezing temperatures by Nagle, W A, Soloff, B L, Moss, Jr, A J, Henle, K J

“…Cultured Chinese hamster V79 fibroblast cells at the transition from logarithmic to stationary growth have been shown to undergo apoptosis (programmed cell…”
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Tumor-targeted delivery of 8-hydroxyquinoline by Monson, T P, Henle, K J, Nagle, W A, Mansouri, A

“…RIF-1 mouse tumors express high levels of beta-glucuronidase activity relative to most normal tissues. The high activity can be exploited for targeting…”
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Protein glycosylation in heat-sensitive and thermotolerance-deficient mutants of Chinese hamster ovary cells by HENLE, K. J, NAGLE, W. A, BEDFORD, J. S, HARVEY, W. F

“…Chinese hamster ovary (CHO) cells are capable of developing a high degree of thermotolerance in response to appropriate heat conditioning. In this study we…”
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Tumor-Targeted Cell Killing with 8-Hydroxyquinolyl-Glucuronide by Henle, Kurt J., Monson, Thomas P., Nagle, William A., Moss, A. Jefferson

“…Many tumors show elevated levels of hydrolytic enzymes that may be associated with invasive processes. The RIF-1 murine tumor has levels of β-glucuronidase…”
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Temperature-Dependent Induction of Thermotolerance by Ethanol by Henle, Kurt J., Moss, A. Jefferson, Nagle, William A.

“…Ethanol (1 M) cytotoxicity in asynchronous Chinese hamster ovary cells was strongly temperature dependent, yielding families of cell survival curves between 34…”
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Interactions of BCNU, low pH, glucose and hyperthermia in cultured RIF cells by Neilan, B A, Jenkins, T L, Henle, K J, Moss, A J, Nagle, W A

“…The interactions of BCNU (1,3-bis[2-chloroethyl]-1-nitrosourea) with low pH, glucose and hyperthermia were studied in cultured RIF tumor cells. The effect of a…”
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Uncoupling of oxidative phosphorylation does not induce thermotolerance in cultured Chinese hamster cells by Rastogi, D, Nagle, W A, Henle, K J, Moss, Jr, A J, Rastogi, S P

“…Two uncouplers of oxidative phosphorylation, 2,4-dinitrophenol (DNP) and carbonyl cyanide m-chlorophenylhydrazone (CCCP), were tested for their ability to…”
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Development of thermotolerance in CHO cells: modification by procaine by Rastogi, D, Henle, K J, Nagle, W A, Moss, A J, Neilan, B A, Rastogi, S P

“…We have tested the reported ability of procaine to inhibit the induction and the development of thermotolerance in Chinese hamster ovary cells. Thermotolerance…”
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Fast neutron and x-ray induced single strand DNA breaks in cultured mammalian cells by Moss, Jr, A J, Baker, M L, Prior, R M, Erichsen, E A, Nagle, W A, Dalrymple, G V

“…The relative biologic effectiveness (RBE) of fast neutrons in the production of single strand DNA breaks is 1.6 as compared to that of 250 kVp x rays…”
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