Search Results - "Nagle, Megha"

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1) by Wikoff, William R, Nagle, Megha A, Kouznetsova, Valentina L, Tsigelny, Igor F, Nigam, Sanjay K

“…Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of…”
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Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue by Nagle, Megha A., Wu, Wei, Eraly, Satish A., Nigam, Sanjay K.

“…► Transport of drugs by the choroid plexus (CP) is believed to be an important factor in regulating CNS drug levels. ► The organic anion transporters Oat1…”
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A role for the organic anion transporter OAT3 in renal creatinine secretion in mice by Vallon, Volker, Eraly, Satish A, Rao, Satish Ramachandra, Gerasimova, Maria, Rose, Michael, Nagle, Megha, Anzai, Naohiko, Smith, Travis, Sharma, Kumar, Nigam, Sanjay K, Rieg, Timo

“…Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular filtration rate (GFR) but the molecular determinants of this…”
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Analysis of Three-dimensional Systems for Developing and Mature Kidneys Clarifies the Role of OAT1 and OAT3 in Antiviral Handling by Nagle, Megha A., Truong, David M., Dnyanmote, Ankur V., Ahn, Sun-Young, Eraly, Satish A., Wu, Wei, Nigam, Sanjay K.

“…The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and…”
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Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice by Eraly, Satish A., Vallon, Volker, Vaughn, Duke A., Gangoiti, Jon A., Richter, Kerstin, Nagle, Megha, Monte, Julio C., Rieg, Timo, Truong, David M., Long, Jeffrey M., Barshop, Bruce A., Kaler, Gregory, Nigam, Sanjay K.

“…The “classical” organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the prototypic organic anion,…”
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Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa by Monte, Julio C., Nagle, Megha A., Eraly, Satish A., Nigam, Sanjay K.

“…The organic anion and cation transporters (OATs and OCTs) are a large family (SLC22) of transmembrane proteins that are able to transport a variety of…”
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Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter—Organic anion transporter1 (Oat1) by Kouznetsova, Valentina L., Tsigelny, Igor F., Nagle, Megha A., Nigam, Sanjay K.

“…Organic anion transporter 1 (Oat1), first identified as NKT, is a multispecific transporter responsible for the handling of drugs and toxins in the kidney and…”
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Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs by Kaler, Gregory, Truong, David M., Khandelwal, Akash, Nagle, Megha, Eraly, Satish A., Swaan, Peter W., Nigam, Sanjay K.

“…Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about…”
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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members by Kaler, Gregory, Truong, David M, Khandelwal, Akash, Nagle, Megha, Eraly, Satish A, Swaan, Peter W, Nigam, Sanjay K

“…Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about…”
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A role for organic anion transporters OAT1 and OAT3 in renal secretion of creatinine by Vallon, Volker, Eraly, Satish, RamachandraRao, Satish, Gerasimova, Maria, Nagle, Megha, Sharma, Kumar, Nigam, Sanjay, Rieg, Timo

“…Tubular secretion of creatinine is known to limit its value as a marker of GFR but the molecular determinants of this pathway are unclear. Organic anion…”
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Key structural features for substrate binding to organic anion transporter 1 (Oat1; slc22a6) identified by global untargeted metabolomics of Oat1null plasma by Wikoff, William R., Nagle, Megha A., Kouznetsova, Valentina L., Tsigelny, Igor F., Nigam, Sanjay K.

“…Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of…”
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Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions by Kaler, Gregory, Truong, David M., Sweeney, Derina E., Logan, Darren W., Nagle, Megha, Wu, Wei, Eraly, Satish A., Nigam, Sanjay K.

“…We have characterized the expression of organic anion transporter 6, Oat6 (slc22a20), in olfactory mucosa, as well as its interaction with several odorant…”
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STRUCTURAL VARIATION GOVERNS SUBSTRATE SPECIFICITY FOR ORGANIC ANION TRANSPORTERS (OAT) HOMOLOGS: POTENTIAL REMOTE SENSING BY OAT FAMILY MEMBERS by Kaler, Gregory, Truong, David M., Khandelwal, Akash, Nagle, Megha, Eraly, Satish A., Swaan, Peter W., Nigam, Sanjay K.

“…Organic Anion Transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about…”
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