Search Results - "Nagies, Falk S. P."
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A spectrum of verticality across genes
Published in PLoS genetics (02-11-2020)“…Lateral gene transfer (LGT) has impacted prokaryotic genome evolution, yet the extent to which LGT compromises vertical evolution across individual genes and…”
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To What Inanimate Matter Are We Most Closely Related and Does the Origin of Life Harbor Meaning?
Published in Philosophies (Basel) (01-06-2021)“…The question concerning the meaning of life is important, but it immediately confronts the present authors with insurmountable obstacles from a philosophical…”
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Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans
Published in Science (American Association for the Advancement of Science) (15-03-2024)“…Humans, like all mammals, depend on the gut microbiome for digestion of cellulose, the main component of plant fiber. However, evidence for cellulose…”
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The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third
Published in FEBS letters (01-07-2024)“…Molecular oxygen is a stable diradical. All O2‐dependent enzymes employ a radical mechanism. Generated by cyanobacteria, O2 started accumulating on Earth 2.4…”
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Gene Duplications Trace Mitochondria to the Onset of Eukaryote Complexity
Published in Genome biology and evolution (07-05-2021)“…Abstract The last eukaryote common ancestor (LECA) possessed mitochondria and all key traits that make eukaryotic cells more complex than their prokaryotic…”
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Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression
Published in JHEP reports (01-10-2024)“…Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease,…”
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