Search Results - "Nagi G. Ayad"

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    Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme by Tan, Sze Kiat, Pastori, Chiara, Penas, Clara, Komotar, Ricardo J, Ivan, Michael E, Wahlestedt, Claes, Ayad, Nagi G

    Published in Molecular cancer (20-03-2018)
    “…Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and…”
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    Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation by Pastori, Chiara, Philipp Kapranov, Clara Penas, Veronica Peschansky, Claude-Henry Volmar, Jann N. Sarkaria, Amade Bregy, Ricardo Komotar, Georges St. Laurent, Nagi G. Ayad, Claes Wahlestedt

    “…Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule…”
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    An overview of human single-cell RNA sequencing studies in neurobiological disease by Walter, T. Jordan, Suter, Robert K., Ayad, Nagi G.

    Published in Neurobiology of disease (01-08-2023)
    “…Neurobiological disorders are highly prevalent medical conditions that contribute to significant morbidity and mortality. Single-cell RNA sequencing…”
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    Epigenetic pathways and plasticity in brain tumors by Suter, Robert K., Rodriguez-Blanco, Jezabel, Ayad, Nagi G.

    Published in Neurobiology of disease (01-11-2020)
    “…Clinical studies have shown that treating many primary brain tumors is challenging due in part to the lack of safe and effective compounds that cross the blood…”
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    Organoid Models of Glioblastoma and Their Role in Drug Discovery by Rybin, Matthew J, Ivan, Michael E, Ayad, Nagi G, Zeier, Zane

    Published in Frontiers in cellular neuroscience (05-02-2021)
    “…Glioblastoma (GBM) is a devastating adult brain cancer with high rates of recurrence and treatment resistance. Cellular heterogeneity and extensive invasion of…”
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    Neuroinflammation Treatment via Targeted Delivery of Nanoparticles by Cerqueira, Susana R, Ayad, Nagi G, Lee, Jae K

    Published in Frontiers in cellular neuroscience (30-09-2020)
    “…The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is…”
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    Kinome-Wide Virtual Screening by Multi-Task Deep Learning by Hu, Jiaming, Allen, Bryce K, Stathias, Vasileios, Ayad, Nagi G, Schürer, Stephan C

    “…Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that…”
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    392 Targeting One-Carbon Metabolism in Brain Cancer by Rowland, Emma, Ayad, Nagi G.

    “…OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis…”
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    The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion by Jermakowicz, Anna M., Rybin, Matthew J., Suter, Robert K., Sarkaria, Jann N., Zeier, Zane, Feng, Yangbo, Ayad, Nagi G.

    Published in Scientific reports (03-12-2021)
    “…Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic targets in multiple cancers, including the most common primary adult brain…”
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    Drug Repositioning in Glioblastoma: A Pathway Perspective by Tan, Sze Kiat, Jermakowicz, Anna, Mookhtiar, Adnan K, Nemeroff, Charles B, Schürer, Stephan C, Ayad, Nagi G

    Published in Frontiers in pharmacology (16-03-2018)
    “…Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current standard of care is surgical resection, radiation, and chemotherapy…”
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    RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma by Jermakowicz, Anna M., Kurimchak, Alison M., Johnson, Katherine J., Bourgain-Guglielmetti, Florence, Kaeppeli, Simon, Affer, Maurizio, Pradhyumnan, Hari, Suter, Robert K., Walters, Winston, Cepero, Maria, Duncan, James S., Ayad, Nagi G.

    Published in Scientific reports (23-04-2024)
    “…Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor…”
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  13. 13

    BET bromodomain proteins are required for glioblastoma cell proliferation by Pastori, Chiara, Daniel, Mark, Penas, Clara, Volmar, Claude-Henry, Johnstone, Andrea L, Brothers, Shaun P, Graham, Regina M, Allen, Bryce, Sarkaria, Jann N, Komotar, Ricardo J, Wahlestedt, Claes, Ayad, Nagi G

    Published in Epigenetics (01-04-2014)
    “…Epigenetic proteins have recently emerged as novel anticancer targets. Among these, bromodomain and extra terminal domain (BET) proteins recognize…”
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    Sororin, a Substrate of the Anaphase- Promoting Complex, Is Required for Sister Chromatid Cohesion in Vertebrates by Rankin, Susannah, Ayad, Nagi G., Kirschner, Marc W.

    Published in Molecular cell (15-04-2005)
    “…We have identified a regulator of sister chromatid cohesion in a screen for cell cycle-controlled proteins. This 35 kDa protein is degraded through…”
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    Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex by Kirschner, Marc W, Kaelin, William G, Wei, Wenyi, Ayad, Nagi G, Wan, Yong, Zhang, Guo-Jun

    Published in Nature (11-03-2004)
    “…Cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key cell-cycle regulators. SCF (Skp1/Cullin/F-box protein) complexes and…”
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    Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer by Yang, Fan, Wynn, Daniel T, Shen, Chen, Ayad, Nagi G, Robbins, David J

    Published in Life (Basel, Switzerland) (24-11-2022)
    “…The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in…”
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    Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner by Winterbottom, Emily F, Moroishi, Yuka, Halchenko, Yuliya, Armstrong, David A, Beach, Paul J, Nguyen, Quang P, Capobianco, Anthony J, Ayad, Nagi G, Marsit, Carmen J, Li, Zhigang, Karagas, Margaret R, Robbins, David J

    Published in Environmental health (28-02-2019)
    “…Prenatal exposure to arsenic has been linked to a range of adverse health conditions in later life. Such fetal origins of disease are frequently the result of…”
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    Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme by Chin, Christopher, Lunking, Emma S, de la Fuente, Macarena, Ayad, Nagi G

    Published in Frontiers in oncology (13-11-2018)
    “…Glioblastoma Multiforme (GBM) is the most common malignant primary brain tumor. Despite aggressive multimodality treatment it remains one of the most…”
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