Search Results - "Nagi G. Ayad"
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Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme
Published in Molecular cancer (20-03-2018)“…Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and…”
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Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2015)“…Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule…”
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3
An overview of human single-cell RNA sequencing studies in neurobiological disease
Published in Neurobiology of disease (01-08-2023)“…Neurobiological disorders are highly prevalent medical conditions that contribute to significant morbidity and mortality. Single-cell RNA sequencing…”
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Epigenetic pathways and plasticity in brain tumors
Published in Neurobiology of disease (01-11-2020)“…Clinical studies have shown that treating many primary brain tumors is challenging due in part to the lack of safe and effective compounds that cross the blood…”
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5
Organoid Models of Glioblastoma and Their Role in Drug Discovery
Published in Frontiers in cellular neuroscience (05-02-2021)“…Glioblastoma (GBM) is a devastating adult brain cancer with high rates of recurrence and treatment resistance. Cellular heterogeneity and extensive invasion of…”
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Neuroinflammation Treatment via Targeted Delivery of Nanoparticles
Published in Frontiers in cellular neuroscience (30-09-2020)“…The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is…”
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Drug and disease signature integration identifies synergistic combinations in glioblastoma
Published in Nature communications (14-12-2018)“…Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months…”
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8
Kinome-Wide Virtual Screening by Multi-Task Deep Learning
Published in International journal of molecular sciences (22-02-2024)“…Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that…”
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392 Targeting One-Carbon Metabolism in Brain Cancer
Published in Journal of clinical and translational science (01-04-2024)“…OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis…”
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The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion
Published in Scientific reports (03-12-2021)“…Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic targets in multiple cancers, including the most common primary adult brain…”
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11
Drug Repositioning in Glioblastoma: A Pathway Perspective
Published in Frontiers in pharmacology (16-03-2018)“…Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current standard of care is surgical resection, radiation, and chemotherapy…”
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12
RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma
Published in Scientific reports (23-04-2024)“…Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor…”
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BET bromodomain proteins are required for glioblastoma cell proliferation
Published in Epigenetics (01-04-2014)“…Epigenetic proteins have recently emerged as novel anticancer targets. Among these, bromodomain and extra terminal domain (BET) proteins recognize…”
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14
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Published in Nature communications (06-09-2021)“…Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the…”
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15
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
Published in Nature communications (10-07-2019)“…Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this…”
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16
Sororin, a Substrate of the Anaphase- Promoting Complex, Is Required for Sister Chromatid Cohesion in Vertebrates
Published in Molecular cell (15-04-2005)“…We have identified a regulator of sister chromatid cohesion in a screen for cell cycle-controlled proteins. This 35 kDa protein is degraded through…”
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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
Published in Nature (11-03-2004)“…Cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key cell-cycle regulators. SCF (Skp1/Cullin/F-box protein) complexes and…”
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Published in Life (Basel, Switzerland) (24-11-2022)“…The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in…”
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19
Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner
Published in Environmental health (28-02-2019)“…Prenatal exposure to arsenic has been linked to a range of adverse health conditions in later life. Such fetal origins of disease are frequently the result of…”
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Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme
Published in Frontiers in oncology (13-11-2018)“…Glioblastoma Multiforme (GBM) is the most common malignant primary brain tumor. Despite aggressive multimodality treatment it remains one of the most…”
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