Search Results - "Nagi, Mahmoud N"

Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity by Nagi, Mahmoud N, Almakki, Hussain A

“…Thymoquinone (TQ), the main constituents of the volatile oil from Nigella sativa seeds is reported to protect laboratory animals against chemical…”
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Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus by Al-Majed, Abdulhakeem A., Al-Omar, Fadhel A., Nagi, Mahmoud N.

“…Increasing evidence demonstrates that oxidative stress plays an important role in brain injury in experimental models of brain ischemia. Thymoquinone, the main…”
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Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones by Al-Omary, Fatmah A.M., Abou-zeid, Laila A., Nagi, Mahmoud N., Habib, El-Sayed E., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., Abdel-Hamide, Sami G., Al-Omar, Mohamed A., Al-Obaid, Abdulrahman M., El-Subbagh, Hussein I.

“…A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor…”
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Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice by Alanazi, Abdulrazaq, Nagi, Mahmoud N., Alhareth, Dhafer Y., Al-Hamamah, Mohammed A, Mahmoud, Mohamed A, Ahmad, Sheikh F., Ansari, Mushtaq A., Nadeem, Ahmed, Bakheet, Saleh A., Harisa, Gamaleldin I., Attia, Sabry M.

“…The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to…”
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Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling by Sayed-Ahmed, Mohamed M, Aleisa, Abdulaziz M, Al-Rejaie, Salim S, Al-Yahya, Abdulaziz A, Al-Shabanah, Othman A, Hafez, Mohamed M, Nagi, Mahmoud N

“…Hepatocellular carcinoma accounts for about 80-90% of all liver cancer and is the fourth most common cause of cancer mortality. Although there are many…”
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Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3 H)-quinazolinone analogs by Al-Rashood, Sarah T., Aboldahab, Ihsan A., Nagi, Mahmoud N., Abouzeid, Laila A., Abdel-Aziz, Alaa A.M., Abdel-hamide, Sami G., Youssef, Khairia M., Al-Obaid, Abdulrahman M., El-Subbagh, Hussein I.

“…In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure…”
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Carfilzomib Mitigates Lipopolysaccharide/D-Galactosamine/Dimethylsulfoxide-Induced Acute Liver Failure in Mice by Alhareth, Dhafer Y, Alanazi, Abdulrazaq, Alanazi, Wael A, Ansari, Mushtaq A, Nagi, Mahmoud N, Ahmad, Sheikh F, Attia, Mohamed S. M, Nadeem, Ahmed, Bakheet, Saleh A, Attia, Sabry M

“…Acute liver failure (ALF) is a disease accompanied by severe liver inflammation. No effective therapy is available yet apart from liver transplantation;…”
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Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action by Mansour, Mahmoud A., Nagi, Mahmoud N., El-Khatib, Aiman S., Al-Bekairi, Abdullah M.

“…The present investigation focused, firstly, on the effects of oral administration of thymoquinone (TQ) on antioxidant enzyme activities, lipid peroxidation and…”
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Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats by Khattab, Mahmoud M., Nagi, Mahmoud N.

“…The present study was undertaken to evaluate the protective effect of thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, in…”
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Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress by Imam, Faisal, Al-Harbi, Naif O., Al-Harbia, Mohammed M., Korashy, Hesham M., Ansari, Mushtaq Ahmad, Sayed-Ahmed, Mohamed M., Nagi, Mahmoud N., Iqbal, Muzaffar, Khalid Anwer, Md, Kazmi, Imran, Afzal, Muhammad, Bahashwan, Saleh

“…Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to…”
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THYMOQUINONE SUPPLEMENTATION PREVENTS THE DEVELOPMENT OF GENTAMICIN‐INDUCED ACUTE RENAL TOXICITY IN RATS by Sayed‐Ahmed, Mohamed M, Nagi, Mahmoud N

“…SUMMARY 1 The present study investigated the possible protective effects of thymoquinone (TQ), a compound derived from Nigella sativa with strong anti‐oxidant…”
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Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats by Mansour, Mahmoud A, Mostafa, Adel M, Nagi, Mahmoud N, Khattab, Mahmoud M, Al-Shabanah, Othman A

“…The effect of aminoguanidine (AG) on nephrotoxicity induced by cisplatin (CDDP) was investigated. A single dose of CDDP (7.5 mg/kg i.p.) induced…”
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Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates by El-Messery, Shahenda M., Hassan, Ghada S., Nagi, Mahmoud N., Habib, El-Sayed E., Al-Rashood, Sarah T., El-Subbagh, Hussein I.

“…The DHFR inhibitors 28, 61; the broad spectrum antibacterial 34; and the antitumor agents 40, 64. [Display omitted] A new series of…”
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Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity by Badary, O A, Nagi, M N, al-Shabanah, O A, al-Sawaf, H A, al-Sohaibani, M O, al-Bekairi, A M

“…The effects of thymoquinone (TQ) on cisplatin-induced nephrotoxicity in mice and rats were studied. Oral administration of TQ (50 mg/L in drinking water) for 5…”
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Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors by Al-Rashood, Sarah T., Hassan, Ghada S., El-Messery, Shahenda M., Nagi, Mahmoud N., Habib, El-Sayed E., Al-Omary, Fatmah A.M., El-Subbagh, Hussein I.

“…Compounds 29, 34 and 39 showed DHFR inhibition (IC50 range of 0.1–0.6μM). Recognition with key amino acids Glu30, Phe31 and Phe34 is essential for receptor…”
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Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones by Al-Omary, Fatmah A.M., Hassan, Ghada S., El-Messery, Shahenda M., Nagi, Mahmoud N., Habib, El-Sayed E., El-Subbagh, Hussein I.

“…A new series of 2-heteroarylthio-6-substituted-quinazolin-4-one analogs was designed, synthesized, and evaluated for their in vitro DHFR inhibition,…”
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Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver by Nagi, Mahmoud N., Almakki, Hussain A., Sayed-Ahmed, Mohamed M., Al-Bekairi, Abdullah M.

“…This study was undertaken to evaluate the protective effect of thymoquinone (TQ) against acetaminophen-induced hepatotoxicity. Mice were given TQ orally at…”
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Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity? by Algfeley, Saleh G., Al‐Rejaie, Salim S., Nagi, Mahmoud N.

“…An overdose of acetaminophen (APAP) causes liver injury in experimental animals and humans. The activation step (formation of reactive metabolite,…”
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Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats by Nagi, Mahmoud N., Al-Shabanah, Othman A., Hafez, Mohamed M., Sayed-Ahmed, Mohamed M.

“…This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against…”
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Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: A possible mechanism of protection by Abd-Allah, Adel RA, Al-Majed, Abdulhakeem A., Mostafa, Adel M., Al-Shabanah, Othman A., Din, Ayman Gamal El, Nagi, Mahmoud N.

“…Arabic gum (AG) is a naturally occurring compound that has been proposed to posses potent antioxidant activity. In this study, the possible effects whereby AG…”
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