Search Results - "Nagendra, S. Ningaraj"

Role of KCNMA1 gene in breast cancer invasion and metastasis to brain by Khaitan, Divya, Sankpal, Umesh T, Weksler, Babette, Meister, Edward A, Romero, Ignacio A, Couraud, Pierre-Olivier, Ningaraj, Nagendra S

“…The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is…”
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Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels by Ningaraj, Nagendra S, Rao, Mamatha, Hashizume, Kazuhiro, Asotra, Kamlesh, Black, Keith L

“…The blood-brain tumor barrier (BTB) limits the delivery of therapeutic drugs to brain tumors. We demonstrate in a rat brain tumor (RG2) model an enhanced drug…”
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Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model by Ningaraj, Nagendra S., Sankpal, Umesh T., Khaitan, Divya, Meister, Edward A., Vats, Tribhawan S.

“…Most anticancer drugs fail to impact patient survival since they fail to cross the blood-brain tumor barrier (BTB) at therapeutic levels. For example,…”
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Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor by Black, Keith L, Ningaraj, Nagendra S

“…The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have…”
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Drug delivery to brain tumours: challenges and progress by Ningaraj, Nagendra S

“…Nearly 12.5 million new cancer cases are diagnosed worldwide each year. Although new treatments have been developed, most new anticancer drugs that are…”
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Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors by Khaitan, Divya, Ningaraj, Nagendra S

“…Every year in the US, 20,000 new primary and nearly 200,000 metastatic brain tumor cases are reported. The cerebral microvessels/capillaries that form the…”
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Activation of KATP channels increases anticancer drug delivery to brain tumors and survival by NINGARAJ, Nagendra S, SANKPAL, Umesh T, KHAITAN, Divya, MEISTER, Edward A, VATS, Trib

“…Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB)…”
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Adenosine 5'-triphosphate-sensitive potassium channel-mediated blood-brain tumor barrier permeability increase in a rat brain tumor model by NINGARAJ, Nagendra S, RAO, Mamatha K, BLACK, Keith L

“…Brain tumor microvessels/capillaries limit drug delivery to tumors by forming a blood-brain tumor barrier (BTB). The BTB overexpresses ATP-sensitive potassium…”
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Role of KCNMA1gene in breast cancer invasion and metastasis to brain by Khaitan, Divya, Sankpal, Umesh T, Weksler, Babette, Meister, Edward A, Romero, Ignacio A, Couraud, Pierre-Olivier, Ningaraj, Nagendra S

“…Abstract Background The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the…”
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Effect of disulfiram administration on glutamate uptake by synaptosomes in the rat brain by Mamatha, R K, Nagendra, S N

“…Although disulfiram used as a pharmacological agent in the treatment of alcoholism is reported to act on both peripheral and central nervous systems with…”
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Carbamoylation of Brain Glutamate Receptors by a Disulfiram Metabolite by Nagendra, S. Ningaraj, Faiman, Morris D., Davis, Kathleen, Wu, Jang-Yen, Newby, Xiangyue, Schloss, John V.

“…S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), a metabolite of the drug disulfiram, is a selective carbamoylating agent for sulfhydryl groups…”
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Activation of K ATP channels increases anticancer drug delivery to brain tumors and survival by Ningaraj, Nagendra S., Sankpal, Umesh T., Khaitan, Divya, Meister, Edward A., Vats, Trib

“…Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB)…”
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Molecular and Cellular Pharmacology: Activation of KATP channels increases anticancer drug delivery to brain tumors and survival by Ningaraj, Nagendra S, Sankpal, Umesh T, Khaitan, Divya, Meister, Edward A, Vats, Trib

“…Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB)…”
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Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier by Ningaraj, Nagendra S, Rao, Mamatha, Black, Keith L

“…Even though the blood-brain tumor barrier (BTB) is more permeable than the blood-brain barrier (BBB), the BTB still significantly restricts the delivery of…”
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Glutathione Carbamoylation with S-Methyl N,N-diethylthiolcarbamate Sulfoxide and Sulfone by Ningaraj, Nagendra S, Schloss, John V, Williams, Todd D, Faiman, Morris D

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Neurotoxic effect of acamprosate, n-acetyl-homotaurine, in cultured neurons by Wu, J Y, Jin, H, Schloss, J V, Faiman, M D, Ningaraj, N S, Foos, T, Chen, W

“…Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its…”
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S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity by Ningaraj, N S, Chen, W, Schloss, J V, Faiman, M D, Wu, J Y

“…Glutamatergic neurotransmission, particularly of the NMDA receptor type, has been implicated in the excitotoxic response to several external and internal…”
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Disulfiram augments oxidative stress in rat brain following bilateral carotid artery occlusion by Ningaraj, N S, Rao, M K

“…We examined the brain oxidative stress which accompanies 30 min of bilateral carotid artery ligation (BCAL) in terms of changes in brain levels of glutathione;…”
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Glutathione Carbamoylation with S-Methyl N, N-diethylthiolcarbamate Sulfoxide and Sulfone : Mitochondrial Low Km Aldehyde Dehydrogenase Inhibition and Implications for Its Alcohol-Deterrent Action by Ningaraj, Nagendra S, Schloss, John V, Williams, Todd D, Faiman, Morris D

“…S-Methyl N, N-diethylthiolcarbamate sulfoxide (DETC-MeSO) and sulfone (DETC-MeSO 2) both inhibit rat liver low K m aldehyde dehydrogenase (ALDH 2) in vitro and…”
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