Search Results - "Nagelhus, Erlend A"

Physiological roles of aquaporin-4 in brain by Nagelhus, Erlend A, Ottersen, Ole P

“…Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor…”
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Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep by Bojarskaite, Laura, Bjørnstad, Daniel M., Pettersen, Klas H., Cunen, Céline, Hermansen, Gudmund Horn, Åbjørsbråten, Knut Sindre, Chambers, Anna R., Sprengel, Rolf, Vervaeke, Koen, Tang, Wannan, Enger, Rune, Nagelhus, Erlend A.

“…Astrocytic Ca 2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an…”
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Impaired glymphatic function and clearance of tau in an Alzheimer's disease model by Harrison, Ian F, Ismail, Ozama, Machhada, Asif, Colgan, Niall, Ohene, Yolanda, Nahavandi, Payam, Ahmed, Zeshan, Fisher, Alice, Meftah, Soraya, Murray, Tracey K, Ottersen, Ole P, Nagelhus, Erlend A, O'Neill, Michael J, Wells, Jack A, Lythgoe, Mark F

“…The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein…”
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Dynamics of Ionic Shifts in Cortical Spreading Depression by Enger, Rune, Tang, Wannan, Vindedal, Gry Fluge, Jensen, Vidar, Johannes Helm, P, Sprengel, Rolf, Looger, Loren L, Nagelhus, Erlend A

“…Cortical spreading depression is a slowly propagating wave of near-complete depolarization of brain cells followed by temporary suppression of neuronal…”
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Loss of perivascular aquaporin‐4 in idiopathic normal pressure hydrocephalus by Hasan‐Olive, Md Mahdi, Enger, Rune, Hansson, Hans‐Arne, Nagelhus, Erlend A., Eide, Per Kristian

“…Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of dementia that may be successfully treated with cerebrospinal fluid (CSF) diversion. Recently,…”
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Aquaporin-4 and epilepsy by Binder, Devin K., Nagelhus, Erlend A., Ottersen, Ole Petter

“…Recent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the…”
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Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain by Thrane, Vinita Rangroo, Thrane, Alexander S., Plog, Benjamin A., Thiyagarajan, Meenakshisundaram, Iliff, Jeffrey J., Deane, Rashid, Nagelhus, Erlend A., Nedergaard, Maiken

“…In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels…”
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Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity by Heuser, Kjell, Nome, Cecilie G, Pettersen, Klas H, Åbjørsbråten, Knut S, Jensen, Vidar, Tang, Wannan, Sprengel, Rolf, Taubøll, Erik, Nagelhus, Erlend A, Enger, Rune

“…Abstract Epileptic seizures are associated with increased astrocytic Ca2+ signaling, but the fine spatiotemporal kinetics of the ictal astrocyte–neuron…”
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Human and mouse cortical astrocytes differ in aquaporin‐4 polarization toward microvessels by Eidsvaag, Vigdis Andersen, Enger, Rune, Hansson, Hans‐Arne, Eide, Per Kristian, Nagelhus, Erlend A.

“…Aquaporin‐4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and ependymal cells. In rodents AQP4 is highly polarized to…”
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Critical role of aquaporin-4 (AQP4) in astrocytic Ca²⁺ signaling events elicited by cerebral edema by Thrane, Alexander S, Rappold, Phillip M, Fujita, Takumi, Torres, Arnulfo, Bekar, Lane K, Takano, Takahiro, Peng, Weiguo, Wang, Fushun, Thrane, Vinita Rangroo, Enger, Rune, Haj-Yasein, Nadia N, Skare, Øivind, Holen, Torgeir, Klungland, Arne, Ottersen, Ole P, Nedergaard, Maiken, Nagelhus, Erlend A

“…Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here, we provide evidence that brain swelling triggers Ca²⁺ signaling in…”
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Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus by Haj-Yasein, Nadia Nabil, Jensen, Vidar, Østby, Ivar, Omholt, Stig W., Voipio, Juha, Kaila, Kai, Ottersen, Ole P., Hvalby, Øivind, Nagelhus, Erlend A.

“…Little is known about the physiological roles of aquaporin‐4 (AQP4) in the central nervous system. AQP4 water channels are concentrated in endfeet membranes of…”
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Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP by Tang, Wannan, Szokol, Karolina, Jensen, Vidar, Enger, Rune, Trivedi, Chintan A, Hvalby, Øivind, Helm, P Johannes, Looger, Loren L, Sprengel, Rolf, Nagelhus, Erlend A

“…To date, it has been difficult to reveal physiological Ca(2+) events occurring within the fine astrocytic processes of mature animals. The objective of the…”
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Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions by Eilert‐Olsen, Martine, Hjukse, Jarand B., Thoren, Anna E., Tang, Wannan, Enger, Rune, Jensen, Vidar, Pettersen, Klas H., Nagelhus, Erlend A.

“…Astrocytic endfeet cover the brain surface and form a sheath around the cerebral vasculature. An emerging concept is that endfeet control blood–brain water…”
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Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients by Hasan-Olive, Md Mahdi, Enger, Rune, Hansson, Hans-Arne, Nagelhus, Erlend A, Eide, Per Kristian

“…A growing body of evidence suggests that the accumulation of amyloid-β and tau (HPτ) in the brain of patients with the dementia subtype idiopathic normal…”
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Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice by Enger, Rune, Dukefoss, Didrik B, Tang, Wannan, Pettersen, Klas H, Bjørnstad, Daniel M, Helm, P Johannes, Jensen, Vidar, Sprengel, Rolf, Vervaeke, Koen, Ottersen, Ole P, Nagelhus, Erlend A

“…Cortical spreading depression (CSD) is a phenomenon that challenges the homeostatic mechanisms on which normal brain function so critically depends. Analyzing…”
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Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice by Åbjørsbråten, Knut Sindre, Skaaraas, Gry HE Syverstad, Cunen, Céline, Bjørnstad, Daniel M, Binder, Kristin M Gullestad, Bojarskaite, Laura, Jensen, Vidar, Nilsson, Lars NG, Rao, Shreyas B, Tang, Wannan, Hermansen, Gudmund Horn, Nagelhus, Erlend A, Ottersen, Ole Petter, Torp, Reidun, Enger, Rune

“…Increased astrocytic Ca 2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced…”
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Role of aquaporin-4 polarization in extracellular solute clearance by Bojarskaite, Laura, Nafari, Sahar, Ravnanger, Anne Katrine, Frey, Mina Martine, Skauli, Nadia, Åbjørsbråten, Knut Sindre, Roth, Lena Catherine, Amiry-Moghaddam, Mahmood, Nagelhus, Erlend A, Ottersen, Ole Petter, Bogen, Inger Lise, Thoren, Anna E, Enger, Rune

“…Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the…”
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Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space by Østby, Ivar, Øyehaug, Leiv, Einevoll, Gaute T, Nagelhus, Erlend A, Plahte, Erik, Zeuthen, Thomas, Lloyd, Catherine M, Ottersen, Ole P, Omholt, Stig W

“…Neuronal stimulation causes approximately 30% shrinkage of the extracellular space (ECS) between neurons and surrounding astrocytes in grey and white matter…”
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Delayed K+Clearance Associated with Aquaporin-4 Mislocalization: Phenotypic Defects in Brains of α-Syntrophin-Null Mice by Amiry-Moghaddam, Mahmood, Williamson, Anne, Palomba, Maria, Eid, Tore, de Lanerolle, Nihal C., Nagelhus, Erlend A., Adams, Marvin E., Froehner, Stanley C., Agre, Peter, Ottersen, Ole P.

“…Recovery from neuronal activation requires rapid clearance of potassium ions (K+)and restoration of osmotic equilibrium. The predominant water channel protein…”
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Augmentation of Ca2+ signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy by Szokol, Karolina, Heuser, Kjell, Tang, Wannan, Jensen, Vidar, Enger, Rune, Bedner, Peter, Steinhäuser, Christian, Taubøll, Erik, Ottersen, Ole Petter, Nagelhus, Erlend A.

“…Astrocytic endfeet are specialized cell compartments whose important homeostatic roles depend on their enrichment of water and ion channels anchored by the…”
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