Search Results - "Nagele, R. G."

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease by D'Andrea, M R, Nagele, R G, Wang, H-Y, Peterson, P A, Lee, D H S

“…Aims: Amyloid has recently been shown to accumulate intracellularly in the brains of patients with Alzheimer's disease (AD), yet amyloid plaques are generally…”
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Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer's disease pathogenesis by D'Andrea, M R, Nagele, R G

“…The details of the sequence of pathological events leading to neuron death in Alzheimer's disease (AD) are not known. Even the formation of amyloid plaques,…”
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Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat by FORMAN, L. J, LIU, P, NAGELE, R. G, YIN, K, WONG, P. Y.-K

“…The effect of ischemia produced by bilateral occlusion of the common carotid arteries (30 min) followed by 4 hours of reperfusion on total and inducible nitric…”
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Intracellular accumulation of β-amyloid1-42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer's disease by NAGELE, R. G, D'ANDREA, M. R, ANDERSON, W. J, WANG, H.-Y

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Simultaneous PCNA and TUNEL labeling for testicular toxicity evaluation suggests that detection of apoptosis may be more sensitive than proliferation by D'Andrea, M R, Alicknavitch, M, Nagele, R G, Damiano, B P

“…We previously reported a sensitive, quantitative immunohistochemical assay using formalin fixed, paraffin embedded rat testicular tissues to assess the degree…”
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Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease by Nagele, R G, D'Andrea, M R, Anderson, W J, Wang, H-Y

“…Amyloid beta(1-42), a major component of amyloid plaques, binds with exceptionally high affinity to the alpha 7 nicotinic acetylcholine receptor and…”
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Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains by Nagele, Robert G, D'Andrea, Michael R, Lee, H, Venkataraman, Venkateswar, Wang, Hoau-Yan

“…beta-Amyloid(1-42) (A beta 42), a major component of amyloid plaques, accumulates within pyramidal neurons in the brains of individuals with Alzheimer's…”
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Negatively Calcium-Modulated Membrane Guanylate Cyclase Signaling System in the Rat Olfactory Bulb by Duda, Teresa, Venkataraman, Venkateswar, Krishnan, Anuradha, Nagele, Robert G, Sharma, Rameshwar K

“…The mechanism by which the individual odor signals are translated into the perception of smell in the brain is unknown. The signal processing occurs in the…”
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Effect of total parenteral nutrition, systemic sepsis, and glutamine on gut mucosa in rats by Yoshida, S., Leskiw, M. J., Schluter, M. D., Bush, K. T., Nagele, R. G., Lanza-Jacoby, S., Stein, T. P.

“…The effect of the combination of total parenteral nutrition (TPN) and systemic sepsis on mucosal morphology and protein synthesis was investigated. Rats were…”
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MAP-2 immunolabeling can distinguish diffuse from dense-core amyloid plaques in brains with Alzheimer's disease by D'Andrea, M R, Nagele, R G

“…Alzheimer's disease (AD) neuropathology is characterized by the presence of diffuse and dense-core (neuritic) amyloid plaques in specific areas of the brain…”
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Chromosome spatial order in human cells: evidence for early origin and faithful propagation by Nagele, R G, Freeman, T, Fazekas, J, Lee, K M, Thomson, Z, Lee, H Y

“…We have investigated the origin and nature of chromosome spatial order in human cells by analyzing and comparing chromosome distribution patterns of normal…”
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PCNA indexing as a preclinical immunohistochemical biomarker for testicular toxicity by D'Andrea, M R, Lawrence, D, Nagele, R G, Wang, C Y, Damiano, B P

“…It is well known that toxicants such as cyclophosphamide and ethanol can have deleterious effects on normal spermatogenesis. End points such as testis weight…”
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Lead alters growth and reduces angiotensin II receptor density of rat aortic smooth muscle cells by Carsia, R V, Forman, D, Hock, C E, Nagele, R G, McIlroy, P J

“…Environmental lead (Pb2+) contributes a small but significant risk to human hypertension. It is postulated that the hypertensinogenic action of Pb2+ may be…”
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Membrane-associated tubulin in the rat anterior pituitary and GH3 cells by Ravindra, R, Nagele, R G, Patel, S A, Freeman, T A

“…Plasma membranes from anterior pituitary lobes of rats and GH3 cells were exposed to monoclonal anti-beta tubulin antibodies or normal mouse IgG, and treated…”
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Chromosomes exhibit preferential positioning in nuclei of quiescent human cells by Nagele, R G, Freeman, T, McMorrow, L, Thomson, Z, Kitson-Wind, K, Lee, H y

“…The relative spatial positioning of chromosomes 7, 8, 16, X and Y was examined in nuclei of quiescent (noncycling) diploid and triploid human fibroblasts using…”
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Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology by Nagele, R G, Velasco, A Q, Anderson, W J, McMahon, D J, Thomson, Z, Fazekas, J, Wind, K, Lee, H

“…The relative sizes of individual telomeres in cultured human cells under conditions of cell cycling, replicative quiescence, cell transformation and…”
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A Novel Calcium-Regulated Membrane Guanylate Cyclase Transduction System in the Olfactory Neuroepithelium by Duda, Teresa, Jankowska, Anna, Venkataraman, Venkateswar, Nagele, Robert G, Sharma, Rameshwar K

“…This report defines the identity of a calcium-regulated membrane guanylate cyclase transduction system in the cilia of olfactory sensory neurons, which is the…”
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Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production by Yue, G, Lai, P S, Yin, K, Sun, F F, Nagele, R G, Liu, X, Linask, K K, Wang, C, Lin, K T, Wong, P Y

“…Peroxynitrite, derived from the reaction of nitric oxide (NO(.)) with superoxide (O(2)), is a potent nitrating and oxidizing agent that can induce apoptosis in…”
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Models to elucidate the regulation of adrenal cell death by Carsia, R. V., Nagele, R. G., Morita, Y., Tilly, K. I., Tilly, J. L.

“…Hypophysectomy-induced apoptosis in the rat adrenal gland is slow (not apparent until 12-24 h) and in-situ, 3′-end labeling (ISEL) of DNA strand breaks is…”
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A new method for the preparation of 'double-fixed', quick-frozen, freeze-substituted cells for whole-cell transmission electron microscopy by Nagele, R G, Lee, H

“…A method is described in which quick-frozen, freeze-substituted, cultured cells can be prepared for whole-cell transmission electron microscopy (WCTEM). This…”
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