Search Results - "Nagel, Jord H.A."

DNAxs/DNAStatistX: Development and validation of a software suite for the data management and probabilistic interpretation of DNA profiles by Benschop, Corina C.G, Hoogenboom, Jerry, Hovers, Pauline, Slagter, Martin, Kruise, Dennis, Parag, Raymond, Steensma, Kristy, Slooten, Klaas, Nagel, Jord H.A, Dieltjes, Patrick, van Marion, Vincent, van Paassen, Heidi, de Jong, Jeroen, Creeten, Christophe, Sijen, Titia, Kneppers, Alexander L.J

“…Highlights•DNA eXpert System for case DNA data management, comparison and interpretation. •DNAxs is future proof and has data connectivity to other software…”
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BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants by ELSTRODT, Fons, HOLLESTELLE, Antoinette, NAGEL, Jord H. A, GORIN, Michael, WASIELEWSKI, Marijke, VAN DEN OUWELAND, Ans, MERAJVER, Sofia D, ETHIER, Stephen P, SCHUTTE, Mieke

“…Germ line mutations of the BRCA1 gene confer a high risk of breast cancer and ovarian cancer to female mutation carriers. The BRCA1 protein is involved in the…”
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Phosphatidylinositol-3-OH Kinase or RAS Pathway Mutations in Human Breast Cancer Cell Lines by Hollestelle, Antoinette, Elstrodt, Fons, Nagel, Jord H A, Kallemeijn, Wouter W, Schutte, Mieke

“…Constitutive activation of the phosphatidylinositol-3-OH kinase (PI3K) and RAS signaling pathways are important events in tumor formation. This is illustrated…”
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Gene expression profiles associated with treatment response in oligodendrogliomas by FRENCH, Pim J, SWAGEMAKERS, Sigrid M. A, NAGEL, Jord H. A, KOUWENHOVEN, Mathilde C. M, BROUWER, Eric, VAN DER SPEK, Peter, LUIDER, Theo M, KROS, Johan M, VAN DEN BENT, Martin J, SILLEVIS SMITT, Peter A

“…Oligodendrogliomas are a specific subtype of brain tumor of which the majority responds favorably to chemotherapy. In this study, we made use of expression…”
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Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes by Nagel, Jord H. A., Peeters, Justine K., Smid, Marcel, Sieuwerts, Anieta M., Wasielewski, Marijke, de Weerd, Vanja, Trapman-Jansen, Anita M. A. C., van den Ouweland, Ans, Brüggenwirth, Hennie, van IJcken, Wilfred F. J., Klijn, Jan G. M., van der Spek, Peter J., Foekens, John A., Martens, John W. M., Schutte, Mieke, Meijers-Heijboer, Hanne

“…CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of…”
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Self-induced structural switches in RNA by Nagel, Jord H.A, Pleij, Cornelis W.A

“…Many biologically active RNAs show a switch in their secondary structure, which is accompanied by changes in their function. Such changes in secondary…”
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Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines by Hollestelle, Antoinette, Nagel, Jord H. A, Smid, Marcel, Lam, Suzanne, Elstrodt, Fons, Wasielewski, Marijke, Ng, Ser Sue, French, Pim J, Peeters, Justine K, Rozendaal, Marieke J, Riaz, Muhammad, Koopman, Daphne G, ten Hagen, Timo L. M, de Leeuw, Bertie H. C. G. M, Zwarthoff, Ellen C, Teunisse, Amina, van der Spek, Peter J, Klijn, Jan G. M, Dinjens, Winand N. M, Ethier, Stephen P, Clevers, Hans, Jochemsen, Aart G, den Bakker, Michael A, Foekens, John A, Martens, John W. M, Schutte, Mieke

“…Breast cancer has for long been recognized as a highly diverse tumor group, but the underlying genetic basis has been elusive. Here, we report an extensive…”
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Development and validation of a fast and automated DNA identification line by Benschop, Corina C.G., Slagter, Martin, Nagel, Jord H.A., Hovers, Pauline, Tuinman, Sietske, Duijs, Francisca E., Grol, Laurens J.W., Jegers, Mariëlle, Berghout, Abigayle, van der Zwan, Anne-Wil, Ypma, Rolf J.F., de Jong, Jeroen, Kneppers, Alexander L.J.

“…The importance of DNA evidence for gaining investigative leads demands a fast workflow for forensic DNA profiling performed in large volumes. Therefore, we…”
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Higher Capillary Electrophoresis Injection Settings as an Efficient Approach to Increase the Sensitivity of STR Typing by Westen, Antoinette A., Nagel, Jord H. A., Benschop, Corina C. G., Weiler, Natalie E. C., De Jong, Bas J., Sijen, Titia

“…:  Evidentiary traces may contain low quantities of DNA, and regularly incomplete short tandem repeat (STR) profiles are obtained. In this study, higher…”
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MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling by WASIELEWSKI, Marijke, NAGEL, Jord H. A, BREKELMANS, Cecile, KLIJN, Jan G. M, VAN DEN OUWELAND, Ans, MEIJERS-HEIJBOER, Hanne, SCHUTTE, Mieke

“…A single nucleotide polymorphism (SNP309T>G) in the intronic promoter of MDM2 was recently found to accelerate carcinogenesis in early-onset cancer cases. This…”
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Exon expression arrays as a tool to identify new cancer genes by Schutte, Mieke, Elstrodt, Fons, Bralten, Linda B C, Nagel, Jord H A, Duijm, Elza, Hollestelle, Antoinette, Vuerhard, Maartje J, Wasielewski, Marijke, Peeters, Justine K, van der Spek, Peter, Sillevis Smitt, Peter A, French, Pim J

“…Identification of genes that are causally implicated in oncogenesis is a major goal in cancer research. An estimated 10-20% of cancer-related gene mutations…”
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