Search Results - "Nagel, D"

Adaptive mutability of colorectal cancers in response to targeted therapies by Russo, Mariangela, Crisafulli, Giovanni, Sogari, Alberto, Reilly, Nicole M, Arena, Sabrina, Lamba, Simona, Bartolini, Alice, Amodio, Vito, Magrì, Alessandro, Novara, Luca, Sarotto, Ivana, Nagel, Zachary D, Piett, Cortt G, Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Corigliano, Mattia, Gherardi, Marco, Lagomarsino, Marco Cosentino, Di Nicolantonio, Federica, Bardelli, Alberto

“…The emergence of drug resistance limits the efficacy of targeted therapies in human tumors. The prevalent view is that resistance is a fait accompli: when…”
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Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies by Nagel, D, Vincendeau, M, Eitelhuber, A C, Krappmann, D

“…The discovery of constitutive nuclear factor-κB (NF-κB) activation in Hodgkin's lymphoma tumor cells almost two decades ago was one of the first reports that…”
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ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade by Shen, Jianfeng, Ju, Zhenlin, Zhao, Wei, Wang, Lulu, Peng, Yang, Ge, Zhongqi, Nagel, Zachary D., Zou, Jun, Wang, Chen, Kapoor, Prabodh, Ma, Xiangyi, Ma, Ding, Liang, Jiyong, Song, Shumei, Liu, Jinsong, Samson, Leona D., Ajani, Jaffer A., Li, Guo-Min, Liang, Han, Shen, Xuetong, Mills, Gordon B., Peng, Guang

“…ARID1A (the AT-rich interaction domain 1A, also known as BAF250a ) is one of the most commonly mutated genes in cancer 1 , 2 . The majority of ARID1A mutations…”
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Human Variation in DNA Repair, Immune Function, and Cancer Risk by Cheong, Ana, Nagel, Zachary D

“…DNA damage constantly threatens genome integrity, and DNA repair deficiency is associated with increased cancer risk. An intuitive and widely accepted…”
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Update 1 of: Tunneling and Dynamics in Enzymatic Hydride Transfer by Nagel, Zachary D, Klinman, Judith P

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Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters by Piett, C. G., Pecen, T. J., Laverty, D. J., Nagel, Z. D.

“…Repair of DNA damage is a critical survival mechanism that affects susceptibility to various human diseases and represents a key target for cancer therapy. A…”
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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme by Nagel, Zachary D, Kitange, Gaspar J, Gupta, Shiv K, Joughin, Brian A, Chaim, Isaac A, Mazzucato, Patrizia, Lauffenburger, Douglas A, Sarkaria, Jann N, Samson, Leona D

“…Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC)…”
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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death by Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.

“…Poly(ADP-ribose)ylation (PARylation) by PAR polymerase 1 (PARP1) and PARylation removal by poly(ADP-ribose) glycohydrolase (PARG) critically regulate DNA…”
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Cosmic Ionizing Radiation: A DNA Damaging Agent That May Underly Excess Cancer in Flight Crews by Toprani, Sneh M, Scheibler, Christopher, Mordukhovich, Irina, McNeely, Eileen, Nagel, Zachary D

“…In the United States, the Federal Aviation Administration has officially classified flight crews (FC) consisting of commercial pilots, cabin crew, or flight…”
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Base excision repair and double strand break repair cooperate to modulate the formation of unrepaired double strand breaks in mouse brain by Polyzos, Aris A., Cheong, Ana, Yoo, Jung Hyun, Blagec, Lana, Toprani, Sneh M., Nagel, Zachary D., McMurray, Cynthia T.

“…We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of…”
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Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis by Nagel, Zachary D., Margulies, Carrie M., Chaim, Isaac A., McRee, Siobhan K., Mazzucato, Patrizia, Ahmad, Anwaar, Abo, Ryan P., Butty, Vincent L., Forget, Anthony L., Samson, Leona D.

“…The capacity to repair different types of DNA damage varies among individuals, making them more or less susceptible to the detrimental health consequences of…”
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ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining by Lu, Huiming, Zhang, Qin, Laverty, Daniel J, Puncheon, Andrew C, Augustine, Mathew M, Williams, Gareth J, Nagel, Zachary D, Chen, Benjamin P C, Davis, Anthony J

“…Abstract Ataxia-telangiectasia mutated (ATM) drives the DNA damage response via modulation of multiple signal transduction and DNA repair pathways. Previously,…”
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Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer by Lee, Kevin J, Piett, Cortt G, Andrews, Joel F, Mann, Elise, Nagel, Zachary D, Gassman, Natalie R

“…DNA repair defects have been increasingly focused on as therapeutic targets. In hormone-positive breast cancer, XRCC1-deficient tumors have been identified and…”
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In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities by Chaim, Isaac A., Nagel, Zachary D., Jordan, Jennifer J., Mazzucato, Patrizia, Ngo, Le P., Samson, Leona D.

“…The integrity of our DNA is challenged with at least 100,000 lesions per cell on a daily basis. Failure to repair DNA damage efficiently can lead to cancer,…”
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CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage by Ngo, Le P., Kaushal, Simran, Chaim, Isaac A., Mazzucato, Patrizia, Ricciardi, Catherine, Samson, Leona D., Nagel, Zachary D., Engelward, Bevin P.

“…Although DNA repair is known to impact susceptibility to cancer and other diseases, relatively few population studies have been performed to evaluate DNA…”
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ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma by Laverty, Daniel J., Gupta, Shiv K., Bradshaw, Gary A., Hunter, Alexander S., Carlson, Brett L., Calmo, Nery Matias, Chen, Jiajia, Tian, Shulan, Sarkaria, Jann N., Nagel, Zachary D.

“…Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a method…”
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Early detection of metastatic disease in asymptomatic breast cancer patients with whole-body imaging and defined tumour marker increase by Di Gioia, D, Stieber, P, Schmidt, G P, Nagel, D, Heinemann, V, Baur-Melnyk, A

“…Background: Follow-up care in breast cancer is still an issue of debate. Diagnostic methods are more sensitive, and more effective therapeutic options are now…”
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The CHD6 chromatin remodeler is an oxidative DNA damage response factor by Moore, Shaun, Berger, N. Daniel, Luijsterburg, Martijn S., Piett, Cortt G., Stanley, Fintan K. T., Schräder, Christoph U., Fang, Shujuan, Chan, Jennifer A., Schriemer, David C., Nagel, Zachary D., van Attikum, Haico, Goodarzi, Aaron A.

“…Cell survival after oxidative DNA damage requires signaling, repair and transcriptional events often enabled by nucleosome displacement, exchange or removal by…”
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Optimized Use of the MALDI BioTyper System and the FilmArray BCID Panel for Direct Identification of Microbial Pathogens from Positive Blood Cultures by Fiori, B, D'Inzeo, T, Giaquinto, A, Menchinelli, G, Liotti, F M, de Maio, F, De Angelis, G, Quaranta, G, Nagel, D, Tumbarello, M, Posteraro, B, Sanguinetti, M, Spanu, T

“…Despite the current reliance on blood cultures (BCs), the diagnosis of bloodstream infections (BSIs) can be sped up using new technologies performed directly…”
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REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors by Vassel, Faye M, Laverty, Daniel J, Bian, Ke, Piett, Cortt G, Hemann, Michael T, Walker, Graham C, Nagel, Zachary D

“…Rev7 is a regulatory protein with roles in translesion synthesis (TLS), double strand break (DSB) repair, replication fork protection, and cell cycle…”
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