Search Results - "Nagata, Sanae"

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva by Hino, Kyosuke, Ikeya, Makoto, Horigome, Kazuhiko, Matsumoto, Yoshihisa, Ebise, Hayao, Nishio, Megumi, Sekiguchi, Kazuya, Shibata, Mitsuaki, Nagata, Sanae, Matsud, Shuichi, Toguchida, Junya

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP…”
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Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva by Hino, Kyosuke, Horigome, Kazuhiko, Nishio, Megumi, Komura, Shingo, Nagata, Sanae, Zhao, Chengzhu, Jin, Yonghui, Kawakami, Koichi, Yamada, Yasuhiro, Ohta, Akira, Toguchida, Junya, Ikeya, Makoto

“…Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification…”
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Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media by Fukuta, Makoto, Nakai, Yoshinori, Kirino, Kosuke, Nakagawa, Masato, Sekiguchi, Kazuya, Nagata, Sanae, Matsumoto, Yoshihisa, Yamamoto, Takuya, Umeda, Katsutsugu, Heike, Toshio, Okumura, Naoki, Koizumi, Noriko, Sato, Takahiko, Nakahata, Tatsutoshi, Saito, Megumu, Otsuka, Takanobu, Kinoshita, Shigeru, Ueno, Morio, Ikeya, Makoto, Toguchida, Junya

“…Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of cell types that contribute to the…”
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New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva by Matsumoto, Yoshihisa, Ikeya, Makoto, Hino, Kyosuke, Horigome, Kazuhiko, Fukuta, Makoto, Watanabe, Makoto, Nagata, Sanae, Yamamoto, Takuya, Otsuka, Takanobu, Toguchida, Junya

“…Successful in vitro disease‐recapitulation using patient‐specific induced pluripotent stem cells (iPSCs) requires two fundamental technical issues: appropriate…”
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Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1 by Maekawa, Hirotsugu, Kawai, Shunsuke, Nishio, Megumi, Nagata, Sanae, Jin, Yonghui, Yoshitomi, Hiroyuki, Matsuda, Shuichi, Toguchida, Junya

“…Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disease characterized by heterotopic ossification (HO) in soft tissues and caused by a…”
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An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva by Hino, Kyosuke, Zhao, Chengzhu, Horigome, Kazuhiko, Nishio, Megumi, Okanishi, Yasue, Nagata, Sanae, Komura, Shingo, Yamada, Yasuhiro, Toguchida, Junya, Ohta, Akira, Ikeya, Makoto

“…Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification…”
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Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes by Jin, Yonghui, Elalaf, Hassan, Watanabe, Makoto, Tamaki, Sakura, Hineno, Sho, Matsunaga, Kazuhito, Woltjen, Knut, Kobayashi, Yukiko, Nagata, Sanae, Ikeya, Makoto, Kato, Jr, Tomohisa, Okamoto, Takeshi, Matsuda, Shuichi, Toguchida, Junya

“…Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite,…”
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3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes by Kawai, Shunsuke, Sunaga, Junko, Nagata, Sanae, Nishio, Megumi, Fukuda, Masayuki, Kamakura, Takeshi, Sun, Liping, Jin, Yonghui, Sakamoto, Satoko, Watanabe, Akira, Matsuda, Shuichi, Adachi, Taiji, Toguchida, Junya

“…Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and…”
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SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier by Tamaki, Sakura, Fukuta, Makoto, Sekiguchi, Kazuya, Jin, Yonghui, Nagata, Sanae, Hayakawa, Kazuo, Hineno, Sho, Okamoto, Takeshi, Watanabe, Makoto, Woltjen, Knut, Ikeya, Makoto, Kato, Jr, Tomohisa, Toguchida, Junya

“…The prevalence and specificity of unique fusion oncogenes are high in a number of soft tissue sarcomas (STSs). The close relationship between fusion genes and…”
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Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs by Maekawa, Hirotsugu, Jin, Yonghui, Nishio, Megumi, Kawai, Shunsuke, Nagata, Sanae, Kamakura, Takeshi, Yoshitomi, Hiroyuki, Niwa, Akira, Saito, Megumu K., Matsuda, Shuichi, Toguchida, Junya

“…Background Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification (HO) in soft tissues due…”
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Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias by Pretemer, Yann, Kawai, Shunsuke, Nagata, Sanae, Nishio, Megumi, Watanabe, Makoto, Tamaki, Sakura, Alev, Cantas, Yamanaka, Yoshihiro, Xue, Jing-Yi, Wang, Zheng, Fukiage, Kenichi, Tsukanaka, Masako, Futami, Tohru, Ikegawa, Shiro, Toguchida, Junya

“…Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been…”
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In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes by Kawai, Shunsuke, Yoshitomi, Hiroyuki, Sunaga, Junko, Alev, Cantas, Nagata, Sanae, Nishio, Megumi, Hada, Masataka, Koyama, Yuko, Uemura, Maya, Sekiguchi, Kazuya, Maekawa, Hirotsugu, Ikeya, Makoto, Tamaki, Sakura, Jin, Yonghui, Harada, Yuki, Fukiage, Kenichi, Adachi, Taiji, Matsuda, Shuichi, Toguchida, Junya

“…The recapitulation of bone formation via the in vitro generation of bone-like nodules is frequently used to understand bone development. However, current…”
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Collagen X Is Dispensable for Hypertrophic Differentiation and Endochondral Ossification of Human iPSC‐Derived Chondrocytes by Kamakura, Takeshi, Jin, Yonghui, Nishio, Megumi, Nagata, Sanae, Fukuda, Masayuki, Sun, Liping, Kawai, Shunsuke, Toguchida, Junya

“…ABSTRACT Collagen X is a non‐fibril collagen produced by hypertrophic chondrocytes and was believed to associate with the calcification process of growth plate…”
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In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes by Kawai, Shunsuke, Yoshitomi, Hiroyuki, Sunaga, Junko, Alev, Cantas, Nagata, Sanae, Nishio, Megumi, Hada, Masataka, Koyama, Yuko, Uemura, Maya, Sekiguchi, Kazuya, Maekawa, Hirotsugu, Ikeya, Makoto, Tamaki, Sakura, Jin, Yonghui, Harada, Yuki, Fukiage, Kenichi, Adachi, Taiji, Matsuda, Shuichi, Toguchida, Junya

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Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells by Nakajima, Taiki, Shibata, Mitsuaki, Nishio, Megumi, Nagata, Sanae, Alev, Cantas, Sakurai, Hidetoshi, Toguchida, Junya, Ikeya, Makoto

“…Somites (SMs) comprise a transient stem cell population that gives rise to multiple cell types, including dermatome (D), myotome (MYO), sclerotome (SCL) and…”
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Automated cell culture system for the production of cell aggregates with growth plate-like structure from induced pluripotent stem cells by Ohta, Akira, Kawai, Shunsuke, Pretemer, Yann, Nishio, Megumi, Nagata, Sanae, Fuse, Hiromitsu, Yamagishi, Yukiko, Toguchida, Junya

“…Programmable liquid handling devices for cell culture systems have dramatically enhanced scalability and reproducibility. We previously reported a protocol to…”
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A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome by Takeda, Yukiko, Ueki, Masahiro, Matsuhiro, Junpei, Walinda, Erik, Tanaka, Takayuki, Yamada, Masafumi, Fujita, Hiroaki, Takezaki, Shunichiro, Kobayashi, Ichiro, Tamaki, Sakura, Nagata, Sanae, Miyake, Noriko, Matsumoto, Naomichi, Osawa, Mitsujiro, Yasumi, Takahiro, Heike, Toshio, Ohtake, Fumiaki, Saito, Megumu K, Toguchida, Junya, Takita, Junko, Ariga, Tadashi, Iwai, Kazuhiro

“…OTULIN-related autoinflammatory syndrome (ORAS), a severe autoinflammatory disease, is caused by biallelic pathogenic variants of OTULIN, a linear…”
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Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva by Sun, Liping, Jin, Yonghui, Nishio, Megumi, Watanabe, Makoto, Kamakura, Takeshi, Nagata, Sanae, Fukuda, Masayuki, Maekawa, Hirotsugu, Kawai, Shunsuke, Yamamoto, Takuya, Toguchida, Junya

“…Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue progenitor cells differentiate into chondrogenic cells. In fibrodysplasia…”
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SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier: e0142991 by Tamaki, Sakura, Fukuta, Makoto, Sekiguchi, Kazuya, Jin, Yonghui, Nagata, Sanae, Hayakawa, Kazuo, Hineno, Sho, Okamoto, Takeshi, Watanabe, Makoto, Woltjen, Knut

“…The prevalence and specificity of unique fusion oncogenes are high in a number of soft tissue sarcomas (STSs). The close relationship between fusion genes and…”
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Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes: e0131998 by Jin, Yonghui, Elalaf, Hassan, Watanabe, Makoto, Tamaki, Sakura, Hineno, Sho, Matsunaga, Kazuhito, Woltjen, Knut, Kobayashi, Yukiko, Nagata, Sanae, Ikeya, Makoto

“…Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite,…”
Get full text