Search Results - "Nagashima, Shinya"

Atomic-Level Observation of Electrochemical Platinum Dissolution and Redeposition by Nagashima, Shinya, Ikai, Toshihiro, Sasaki, Yuki, Kawasaki, Tadahiro, Hatanaka, Tatsuya, Kato, Hisao, Kishita, Keisuke

“…An understanding of electrochemical dynamics at solid–liquid interfaces is essential to develop advanced batteries and fuel cells and so on. For example, an…”
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Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors by Nagashima, Shinya, Yokota, Masaki, Nakai, Ei-ichi, Kuromitsu, Sadao, Ohga, Keiko, Takeuchi, Makoto, Tsukamoto, Shin-ichi, Ohta, Mitsuaki

“…2-{[2-(4-Hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamide derivatives were prepared and their STAT6 inhibitory activities were evaluated. Compound 2t…”
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Atomistic Field Emission Distributions of Highly Oriented Pyrolytic Graphite Surfaces with Defects by Nagashima, Shinya, Ogata, Satoshi, Yamada, Yoichi, Sasaki, Masahiro

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Investigation of the transient freeze start behavior of polymer electrolyte fuel cells by Sabharwal, Mayank, Büchi, Felix N., Nagashima, Shinya, Marone, Federica, Eller, Jens

“…Understanding the water management in polymer electrolyte fuel cells during sub-zero operation is crucial for designing effective freeze start strategies. This…”
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Temperature dependent water transport mechanism in gas diffusion layers revealed by subsecond operando X-ray tomographic microscopy by Xu, Hong, Nagashima, Shinya, Nguyen, Hai P., Kishita, Keisuke, Marone, Federica, Büchi, Felix N., Eller, Jens

“…The product water of polymer electrolyte fuel cells (PEFCs) has to pervade the gas diffusion layer (GDL) and can lead to shortages of educt gas diffusion…”
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Novel Malonamide Derivatives as αvβ3 Antagonists. Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with αvβ3 by NAGASHIMA, Shinya, AKAMATSU, Seijiro, KAWAMINAMI, Eiji, KAWAZOE, Souichirou, OGAMI, Tetsuro, MATSUMOTO, Yuzo, OKADA, Minoru, SUZUKI, Ken-Ichi, TSUKAMOTO, Shin-Ichi

“…In attempt to find novel integrin αvβ3 antagonists, we selected SC65811 and its guanidine analogue (1) as lead compounds. Modification of the glycine part of…”
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Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug–drug interactions and P-gp liability by Kunikawa, Shigeki, Tanaka, Akira, Mukoyoshi, Koichiro, Nagashima, Shinya, Tominaga, Hiroaki, Chida, Noboru, Tasaki, Mamoru, Shirai, Fumiyuki

“…[Display omitted] Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as…”
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Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists by Nagashima, Shinya, Matsushima, Yuji, Hamaguchi, Hisao, Nagata, Hiroshi, Kontani, Toru, Moritomo, Ayako, Koshika, Tadatsura, Takeuchi, Makoto

“…A novel quinuclidinyl heteroarylcarbamate derivative ASP9133 was identified as a long-acting muscarinic antagonist (LAMA) showing more selective inhibition of…”
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Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors by Nagashima, Shinya, Hondo, Takeshi, Nagata, Hiroshi, Ogiyama, Takashi, Maeda, Jun, Hoshii, Hiroaki, Kontani, Toru, Kuromitsu, Sadao, Ohga, Keiko, Orita, Masaya, Ohno, Kazuki, Moritomo, Ayako, Shiozuka, Koichi, Furutani, Masako, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in interleukin (IL)-4 signaling pathway and a key regulator…”
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YM-341619 suppresses the differentiation of spleen T cells into Th2 cells in vitro, eosinophilia, and airway hyperresponsiveness in rat allergic models by Ohga, Keiko, Kuromitsu, Sadao, Takezawa, Ryuichi, Numazaki, Mako, Ishikawa, Jun, Nagashima, Shinya, Shimizu, Yasuaki

“…T helper (Th) 2 cells play a central role in the pathogenesis of allergic diseases such as allergic asthma, atopic dermatitis, and allergic rhinitis. We have…”
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Novel 5-Hydroxytryptamine (5-HT3) Receptor Antagonists. IV. Synthesis and Pharmacological Evaluation of the Oxidation Products of (-)-(R)-5-((1-Methyl-1H-indol-3-yl)carbonyl)-4,5,6,7 tetrahydro-1H-benzimidazole Hydrochloride (YM060: Ramosetron) by OHTA, Mitsuaki, SUZUKI, Takeshi, NAGASHIMA, Shinya, TOKUNAGA, Tatsuhiro, MIYATA, Keiji, MASE, Toshiyasu

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l-MENTHYL (2S)-2-PHENYL-3-(p-ANISYL)-(5Z)-BENZYLIDENE-4, 6-DIOXO-1, 3-OXAZINE-2-CARBOXYLATE : A NEW CHIRAL HETERODIENE AND MICHAEL ACCEPTOR by SATO, Masayuki, NAGASHIMA, Shinya, FURUYA, Toshio, KANEKO, Chikara

“…The tite homochiral oxazinedione has been synthesized from l-menthyl phenylglyoxylate in three steps and found to exhibit high diastereofacial selectivity…”
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Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors by Nagashima, Shinya, Nagata, Hiroshi, Iwata, Masahiro, Yokota, Masaki, Moritomo, Hiroyuki, Orita, Masaya, Kuromitsu, Sadao, Koakutsu, Akiko, Ohga, Keiko, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The novel 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivative 25y (YM-341619, AS1617612) potently inhibited STAT6 activation and…”
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Novel 7 H-pyrrolo[2,3- d]pyrimidine derivatives as potent and orally active STAT6 inhibitors by Nagashima, Shinya, Hondo, Takeshi, Nagata, Hiroshi, Ogiyama, Takashi, Maeda, Jun, Hoshii, Hiroaki, Kontani, Toru, Kuromitsu, Sadao, Ohga, Keiko, Orita, Masaya, Ohno, Kazuki, Moritomo, Ayako, Shiozuka, Koichi, Furutani, Masako, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The novel 7 H-pyrrolo[2,3- d]pyrimidine derivative 24 (AS1810722) inhibited STAT6 activation with an IC 50 value of 1.9 nM and showed a good profile of CYP3A4…”
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Novel Malonamide Derivatives as [alpha]v[beta]3 Antagonists. Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with [alpha]v[beta]3 by NAGASHIMA, Shinya, AKAMATSU, Seijiro, KAWAMINAMI, Eiji, KAWAZOE, Souichirou, OGAMI, Tetsuro, MATSUMOTO, Yuzo, OKADA, Minoru, SUZUKI, Ken-Ichi, TSUKAMOTO, Shin-Ichi

“…In attempt to find novel integrin αvβ3 antagonists, we selected SC65811 and its guanidine analogue (1) as lead compounds. Modification of the glycine part of…”
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Novel Malonamide Derivatives as .ALPHA.v.BETA.3 Antagonists. Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-Oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with .ALPHA.v.BETA.3 by NAGASHIMA, Shinya, AKAMATSU, Seijiro, KAWAMINAMI, Eiji, KAWAZOE, Souichirou, OGAMI, Tetsuro, MATSUMOTO, Yuzo, OKADA, Minoru, SUZUKI, Ken-Ichi, TSUKAMOTO, Shin-Ichi

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Novel 5-Hydroxytryptamine (5-HT3) Receptor Antagonists. IV. Synthesis and Pharmacological Evaluation of the Oxidation Products of (-)-(R)-5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4, 5, 6, 7-tetrahydro-1H-benzimidazole Hydrochloride (YM060 : Ramosetron) by OHTA, Mitsuaki, SUZUKI, Takeshi, NAGASHIMA, Shinya, TOKUNAGA, Tatsuhiro, MIYATA, Keiji, MASE, Toshiyasu

“…In physicochemical and pharmacokinetic evaluations of (-)-(R)-5-[(1-methyl-1H-indol-3-yl)carbonyl]-4, 5, 6, 7-tetrahydro-1H-benzimidazole hydrochloride 1…”
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Adaptor Protein Crk is Implicated in Mucus Formation in Mucinous Epithelial Ovarian Cancer （mEOC） Cells MCAS by 徐冬梅 令狐华 Masumi Tsuda Shinya Tanaka Kazuo Nagashima

“…Objective： The mucus production is an indicator for the histological grade of mucinous epithelial ovarian cancer （mEOC）. In our previous study, Crk expression…”
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