Search Results - "Nagashima, Hiroyuki"

Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4 + T Cells by Nagashima, Hiroyuki, Ishii, Naoto, So, Takanori

“…There is growing evidence that tumor necrosis factor (TNF) receptor-associated factors (TRAFs) bind to unconventional membrane-bound receptors in many cell…”
Get full text

TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development by Nagashima, Hiroyuki, Okuyama, Yuko, Hayashi, Takaya, Ishii, Naoto, So, Takanori

“…IL-17-producing CD4(+) T cells (Th17 cells) regulate host defense and immune pathogenesis, and IL-6 plays an important role for the differentiation of Th17…”
Get full text

TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4+ T-Lymphocytes by So, Takanori, Nagashima, Hiroyuki, Ishii, Naoto

“…CD4+ T helper cells (TH cells), such as TH1, TH2, TH17, TFH, and Treg cells, play critical roles in host defense against infection and in the pathogenesis of…”
Get full text

MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 by Mikami, Yohei, Philips, Rachael L., Sciumè, Giuseppe, Petermann, Franziska, Meylan, Françoise, Nagashima, Hiroyuki, Yao, Chen, Davis, Fred P., Brooks, Stephen R., Sun, Hong-Wei, Takahashi, Hayato, Poholek, Amanda C., Shih, Han-Yu, Afzali, Behdad, Muljo, Stefan A., Hafner, Markus, Kanno, Yuka, O’Shea, John J.

“…MicroRNAs are important regulators of immune responses. Here, we show miR-221 and miR-222 modulate the intestinal Th17 cell response. Expression of miR-221 and…”
Get full text

Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells by Sciumè, Giuseppe, Mikami, Yohei, Jankovic, Dragana, Nagashima, Hiroyuki, Villarino, Alejandro V., Morrison, Tasha, Yao, Chen, Signorella, Sadie, Sun, Hong-Wei, Brooks, Stephen R., Fang, Difeng, Sartorelli, Vittorio, Nakayamada, Shingo, Hirahara, Kiyoshi, Zitti, Beatrice, Davis, Fred P., Kanno, Yuka, O’Shea, John J., Shih, Han-Yu

“…Innate immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs). In natural…”
Get full text

TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK–JAK interaction by Kimura, Masanobu, Nagashima, Hiroyuki, Okuyama, Yuko, Ishii, Naoto, So, Takanori

“…TRAF-family members prevent IL-6R-mediated JAK-JAK interaction Abstract Tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 constitutively…”
Get full text

Improved efficacy to cytotoxic agents chemotherapy after immune checkpoint inhibitors exposure in metastatic gastric cancer by Sagawa, Tamotsu, Sato, Yasushi, Hamaguchi, Kyoko, Hirakawa, Masahiro, Nagashima, Hiroyuki, Waga, Eriko, Fujikawa, Koshi, Takahashi, Yasuo

“…Abstract only 297 Background: An association between improved responses to chemotherapy after exposure to vaccine-based immunotherapy has been previously…”
Get full text

Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis by Sasaki, Tomoki, Nagashima, Hiroyuki, Okuma, Atsushi, Yamauchi, Takeshi, Yamasaki, Kenshi, Aiba, Setsuya, So, Takanori, Ishii, Naoto, Owada, Yuji, MaruYama, Takashi, Kobayashi, Shuhei

“…Background The Toll-like receptor signaling pathway contributes to the regulation of intestinal homeostasis through interactions with commensal bacteria…”
Get full text

Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report by Sagawa, Tamotsu, Sato, Yasushi, Nagashima, Hiroyuki, Takada, Kohichi, Takahashi, Mamoru, Hirakawa, Masahiro, Hamaguchi, Kyoko, Tamura, Fumito, Fujikawa, Koshi, Okamoto, Koichi, Kawano, Yutaka, Sogabe, Masahiro, Miyamoto, Hiroshi, Takayama, Tetsuji

“…Immune checkpoint inhibitors (ICIs) are the standard treatment for metastatic colorectal cancer (mCRC) with high microsatellite instability (MSI-H). Among…”
Get full text

Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study by Takada, Kohichi, Kubo, Tomohiro, Kikuchi, Junko, Yoshida, Makoto, Murota, Ayako, Arihara, Yohei, Nakamura, Hajime, Nagashima, Hiroyuki, Tanabe, Hiroki, Sugita, Shintaro, Tanaka, Yumi, Miura, Ayana, Ohhara, Yoshihito, Ishiguro, Atsushi, Yokouchi, Hiroshi, Kawamoto, Yasuyuki, Mizukami, Yusuke, Ohnishi, Hirofumi, Kinoshita, Ichiro, Sakurai, Akihiro

“…Characterization of the genomic landscape of biliary tract cancer (BTC) may lead to applying genotype-matched therapy for patients with this disease. Evidence…”
Get full text

Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic by Ono, Takaaki, Cruz, Modesto, Nagashima, Hiroyuki, Subsomwong, Phawinee, Akada, Junko, Matsumoto, Takashi, Uchida, Tomohisa, Suzuki, Rumiko, Hosking, Celso, Jiménez Abreu, José A, Yamaoka, Yoshio

“…( ) colonizes the human stomach and is a major cause of peptic ulcer disease and gastric cancer. However, although the prevalence of is high in Africa, the…”
Get full text

Interleukin-17C in Human Helicobacter pylori Gastritis by Tanaka, Shingo, Nagashima, Hiroyuki, Cruz, Modesto, Uchida, Tomohisa, Uotani, Takahiro, Jiménez Abreu, José A, Mahachai, Varocha, Vilaichone, Ratha-Korn, Ratanachu-Ek, Thawee, Tshering, Lotay, Graham, David Y, Yamaoka, Yoshio

“…The interleukin-17 (IL-17) family of cytokines (IL-17A to IL-17F) is involved in many inflammatory diseases. Although IL-17A is recognized as being involved in…”
Get full text

Case Report: Longitudinal monitoring of clonal evolution by circulating tumor DNA for resistance to anti-EGFR antibody in a case of metastatic colorectal cancer by Sagawa, Tamotsu, Sato, Yasushi, Hirakawa, Masahiro, Hamaguchi, Kyoko, Tamura, Fumito, Nagashima, Hiroyuki, Fujikawa, Koshi, Okamoto, Koichi, Kawano, Yutaka, Sogabe, Masahiro, Miyamoto, Hiroshi, Takayama, Tetsuji

“…Treatment with anti-EGFR antibody has been shown to prolong survival in patients with RAS wild-type metastatic colorectal cancer (mCRC). However, even patients…”
Get full text

Changes of tight junction and interleukin‐8 expression using a human gastroid monolayer model of Helicobacter pylori infection by Uotani, Takahiro, Murakami, Kosuke, Uchida, Tomohisa, Tanaka, Shingo, Nagashima, Hiroyuki, Zeng, Xi‐Lei, Akada, Junko, Estes, Mary K., Graham, David Y., Yamaoka, Yoshio

“…Background Lack of a model that mirrors Helicobacter pylori‐induced gastric mucosal inflammation has hampered investigation of early host‐bacterial…”
Get full text

Clarithromycin-Based Triple Therapy is Still Useful as an Initial Treatment for Helicobacter pylori Infection in the Dominican Republic by Miftahussurur, Muhammad, Cruz, Modesto, Subsomwong, Phawinee, Jiménez Abreu, José A, Hosking, Celso, Nagashima, Hiroyuki, Akada, Junko, Yamaoka, Yoshio

“…Abstract antibiotic susceptibility in the Dominican Republic has not been monitored. We assessed antibiotic susceptibility in the Dominican Republic, and…”
Get full text

Comparative study between Helicobacter pylori and host human genetics in the Dominican Republic by Ono, Takaaki, Cruz, Modesto, Jiménez Abreu, José A, Nagashima, Hiroyuki, Subsomwong, Phawinee, Hosking, Celso, Shiota, Seiji, Suzuki, Rumiko, Yamaoka, Yoshio

“…Helicobacter pylori, a bacterium that infects the human stomach, has high genetic diversity. Because its evolution is parallel to human, H. pylori is used as a…”
Get full text

Randomized Double-Blind Trial of Sulindac and Etodolac to Eradicate Aberrant Crypt Foci and to Prevent Sporadic Colorectal Polyps by TAKAYAMA, Tetsuji, NAGASHIMA, Hiroyuki, SONODA, Tomoko, KIMURA, Tetsuo, KATO, Junji, NIITSU, Yoshiro, MAEDA, Masahiro, NOJIRI, Shuichi, HIRAYAMA, Michiaki, NAKANO, Yoichiro, TAKAHASHI, Yasuo, SATO, Yasushi, SEKIKAWA, Hitoshi, MORI, Mitsuru

“…On the basis of the results of our preliminary trial suggesting that aberrant crypt foci (ACF) could be eradicated by short-term administration of sulindac, in…”
Get full text

Identification of the genes that contribute to lactate utilization in Helicobacter pylori by Iwatani, Shun, Nagashima, Hiroyuki, Reddy, Rita, Shiota, Seiji, Graham, David Y, Yamaoka, Yoshio

“…Helicobacter pylori are Gram-negative, spiral-shaped microaerophilic bacteria etiologically related to gastric cancer. Lactate utilization has been implicated…”
Get full text

Differences in interleukin 8 expression in Helicobacter pylori –infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic by Nagashima, Hiroyuki, MD, PhD, Iwatani, Shun, PhD, Cruz, Modesto, MD, PhD, Jiménez Abreu, José A., MD, Tronilo, Lourdes, MD, Rodríguez, Eduardo, MD, Disla, Mildre, MD, Terao, Hideo, MD, PhD, Uchida, Tomohisa, MD, PhD, Mahachai, Varocha, MD, Vilaichone, Ratha-korn, MD, Tshering, Lotay, MD, Mitsui, Takahiro, MD, PhD, Shiota, Seiji, MD, PhD, Graham, David Y., MD, Yamaoka, Yoshio, MD, PhD

“…Summary The outcomes of Helicobacter pylori infection vary geographically. H pylori strains, disease presentation, and environments differ markedly in Bhutan…”
Get full text

Virulence genes of Helicobacter pylori in the Dominican Republic by SHIOTA, Seiji, CRUZ, Modesto, TRONILO, Lourdes, RODRIGUEZ, Eduardo, YAMAOKA, Yoshio, ABREU, José A. Jiménez, MITSUI, Takahiro, TERAO, Hideo, DISLA, Mildre, IWATANI, Shun, NAGASHIMA, Hiroyuki, MATSUDA, Miyuki, UCHIDA, Tomohisa

“…Although the incidence of gastric cancer in the Dominican Republic is not high, the disease remains a significant health problem. We first conducted a detailed…”
Get full text