Search Results - "Nagarajan, Shilpa R."

The diversity and breadth of cancer cell fatty acid metabolism by Nagarajan, Shilpa R, Butler, Lisa M, Hoy, Andrew J

“…Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular…”
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Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism by Nagarajan, Shilpa R, Paul-Heng, Moumita, Krycer, James R, Fazakerley, Daniel J, Sharland, Alexandra F, Hoy, Andrew J

“…The liver is a critical tissue for maintaining glucose, fatty acid, and cholesterol homeostasis. Primary hepatocytes represent the gold standard for studying…”
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Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer by Balaban, Seher, Nassar, Zeyad D, Zhang, Alison Y, Hosseini-Beheshti, Elham, Centenera, Margaret M, Schreuder, Mark, Lin, Hui-Ming, Aishah, Atqiya, Varney, Bianca, Liu-Fu, Frank, Lee, Lisa S, Nagarajan, Shilpa R, Shearer, Robert F, Hardie, Rae-Anne, Raftopulos, Nikki L, Kakani, Meghna S, Saunders, Darren N, Holst, Jeff, Horvath, Lisa G, Butler, Lisa M, Hoy, Andrew J

“…Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased…”
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Tumour fatty acid metabolism in the context of therapy resistance and obesity by Hoy, Andrew J., Nagarajan, Shilpa R., Butler, Lisa M.

“…Fatty acid metabolism is known to support tumorigenesis and disease progression as well as treatment resistance through enhanced lipid synthesis, storage and…”
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Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation by Nagarajan, Shilpa R., Cross, Eloise, Johnson, Elspeth, Sanna, Fabio, Daniels, Lorna J., Ray, David W., Hodson, Leanne

“…Pathological accumulation of intrahepatic triglyceride underpins the early stages of nonalcoholic fatty liver disease (NAFLD) and can progress to fibrosis,…”
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Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver by Nagarajan, Shilpa R, Brandon, Amanda E, McKenna, Jessie A, Shtein, Harrison C, Nguyen, Thinh Q, Suryana, Eurwin, Poronnik, Philip, Cooney, Gregory J, Saunders, Darren N, Hoy, Andrew J

“…Ubiquitin is a crucial post-translational modification regulating numerous cellular processes, but its role in metabolic disease is not well characterized. In…”
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Hepatocyte mARC1 promotes fatty liver disease by Lewis, Lara C., Chen, Lingyan, Hameed, L. Shahul, Kitchen, Robert R., Maroteau, Cyrielle, Nagarajan, Shilpa R., Norlin, Jenny, Daly, Charlotte E., Szczerbinska, Iwona, Hjuler, Sara Toftegaard, Patel, Rahul, Livingstone, Eilidh J., Durrant, Tom N., Wondimu, Elisabeth, BasuRay, Soumik, Chandran, Anandhakumar, Lee, Wan-Hung, Hu, Sile, Gilboa, Barak, Grandi, Megan E., Toledo, Enrique M., Erikat, Abdullah H.A., Hodson, Leanne, Haynes, William G., Pursell, Natalie W., Coppieters, Ken, Fleckner, Jan, Howson, Joanna M.M., Andersen, Birgitte, Ruby, Maxwell A.

“…Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human…”
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Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover by Raftopulos, Nikki L, Washaya, Tinashe C, Niederprüm, Andreas, Egert, Antonia, Hakeem-Sanni, Mariam F, Varney, Bianca, Aishah, Atqiya, Georgieva, Mariya L, Olsson, Ellinor, Dos Santos, Diandra Z, Nassar, Zeyad D, Cochran, Blake J, Nagarajan, Shilpa R, Kakani, Meghna S, Hastings, Jordan F, Croucher, David R, Rye, Kerry-Anne, Butler, Lisa M, Grewal, Thomas, Hoy, Andrew J

“…Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However,…”
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Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver by Nagarajan, Shilpa R, Brandon, Amanda E, McKenna, Jessie A, Shtein, Harrison C, Nguyen, Thinh Q, Suryana, Eurwin, Poronnik, Philip, Cooney, Gregory J, Saunders, Darren N, Hoy, Andrew J

“…[This corrects the article DOI: 10.1371/journal.pone.0174431.]…”
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Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis by Gunn, Pippa J., Pramfalk, Camilla, Millar, Val, Cornfield, Thomas, Hutchinson, Matthew, Johnson, Elspeth M., Nagarajan, Shilpa R., Troncoso‐Rey, Perla, Mithen, Richard F., Pinnick, Katherine E., Traka, Maria H., Green, Charlotte J., Hodson, Leanne

“…Background and Aims Nonalcoholic fatty liver disease (NAFLD) begins with steatosis, where a mixed macrovesicular pattern of large and small lipid droplets…”
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Insulin signaling requires glucose to promote lipid anabolism in adipocytes by Krycer, James R., Quek, Lake-Ee, Francis, Deanne, Zadoorian, Armella, Weiss, Fiona C., Cooke, Kristen C., Nelson, Marin E., Diaz-Vegas, Alexis, Humphrey, Sean J., Scalzo, Richard, Hirayama, Akiyoshi, Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Huynh, Kevin, Giles, Corey, Varney, Bianca, Nagarajan, Shilpa R., Hoy, Andrew J., Soga, Tomoyoshi, Meikle, Peter J., Cooney, Gregory J., Fazakerley, Daniel J., James, David E.

“…Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This is coordinated by insulin,…”
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Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice by Van Woerkom, Andries, Harney, Dylan J, Nagarajan, Shilpa R, Hakeem-Sanni, Mariam F, Lin, Jinfeng, Hooke, Matthew, Pulpitel, Tamara, Cooney, Gregory J, Larance, Mark, Saunders, Darren N, Brandon, Amanda E, Hoy, Andrew J

“…Fatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the…”
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Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans by Westcott, Felix A, Nagarajan, Shilpa R, Parry, Sion A, Savic, Dragana, Green, Charlotte J, Marjot, Thomas, Johnson, Elspeth, Cornfield, Thomas, Mózes, Ferenc E, O'Rourke, Paige, Mendall, Jessica, Dearlove, David, Fielding, Barbara, Smith, Kieran, Tomlinson, Jeremy W, Hodson, Leanne

“…Fasting hyperglycemia and hypertriglyceridemia are characteristic of insulin resistance (IR) and rodent work has suggested this may be due to selective hepatic…”
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MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies by Nagarajan, Shilpa R., Livingstone, Eilidh J., Monfeuga, Thomas, Lewis, Lara C., Ali, Shahul Hameed Liyakath, Chandran, Anandhakumar, Dearlove, David J., Neville, Matt J., Chen, Lingyan, Maroteau, Cyrielle, Ruby, Maxwell A., Hodson, Leanne

“…Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein…”
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Reporting of ethics in peer-reviewed verbal autopsy studies: a systematic review by Joshi, Rohina, Faruqui, Neha, Nagarajan, Shilpa R, Rampatige, Rasika, Martiniuk, Alex, Gouda, Hebe

“…Verbal autopsy (VA) is a method that determines the cause of death by interviewing a relative of the deceased about the events occurring before the death, in…”
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Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition by Nassar, Zeyad D, Mah, Chui Yan, Centenera, Margaret M, Irani, Swati, Sadowski, Martin C, Scott, Julia S, Nguyen, Elizabeth V, Nagarajan, Shilpa R, Moldovan, Max, Lynn, David J, Daly, Roger J, Hoy, Andrew J, Butler, Lisa M

“…HSP90 is a molecular chaperone required for stabilization and activation of hundreds of client proteins, including many known oncoproteins. AUY922…”
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Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation by Cairns, Rose, Alvarez-Guaita, Anna, Martínez-Saludes, Inés, Wason, Sundeep J., Hanh, Jacky, Nagarajan, Shilpa R., Hosseini-Beheshti, Elham, Monastyrskaya, Katia, Hoy, Andrew J., Buechler, Christa, Enrich, Carlos, Rentero, Carles, Grewal, Thomas

“…Annexin A6 (AnxA6) has been implicated in the regulation of endo-/exocytic pathways, cholesterol transport, and the formation of multifactorial signaling…”
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