Search Results - "Nagarajan, Raman P"

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer by Bell, Robert J. A., Rube, H. Tomas, Kreig, Alex, Mancini, Andrew, Fouse, Shaun D., Nagarajan, Raman P., Choi, Serah, Hong, Chibo, He, Daniel, Pekmezci, Melike, Wiencke, John K., Wrensch, Margaret R., Chang, Susan M., Walsh, Kyle M., Myong, Sua, Song, Jun S., Costello, Joseph F.

“…Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental…”
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Epigenetic mechanisms in glioblastoma multiforme by Nagarajan, Raman P, Costello, Joseph F

“…Abstract Glioblastoma multiforme (GBM) is an aggressive and lethal cancer, accounting for the majority of primary brain tumors in adults. GBMs are…”
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Non-invasive genetic monitoring for the threatened valley elderberry longhorn beetle by Nagarajan, Raman P, Goodbla, Alisha, Graves, Emily, Baerwald, Melinda, Holyoak, Marcel, Schreier, Andrea

“…The valley elderberry longhorn beetle (VELB), Desmocerus californicus dimorphus (Coleoptera: Cerambycidae), is a federally threatened subspecies endemic to the…”
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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes by Yasui, Dag H, Peddada, Sailaja, Bieda, Mark C, Vallero, Roxanne O, Hogart, Amber, Nagarajan, Raman P, Thatcher, Karen N, Farnham, Peggy J, LaSalle, Janine M

“…Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the…”
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15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders by Hogart, Amber, Nagarajan, Raman P., Patzel, Katherine A., Yasui, Dag H., LaSalle, Janine M.

“…Human chromosome 15q11-13 is a complex locus containing imprinted genes as well as a cluster of three GABAA receptor subunit (GABR) genes—GABRB3, GABRA5 and…”
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Epigenetic and transcriptional determinants of the human breast by Gascard, Philippe, Bilenky, Misha, Sigaroudinia, Mahvash, Zhao, Jianxin, Li, Luolan, Carles, Annaick, Delaney, Allen, Tam, Angela, Kamoh, Baljit, Cho, Stephanie, Griffith, Malachi, Chu, Andy, Robertson, Gordon, Cheung, Dorothy, Li, Irene, Heravi-Moussavi, Alireza, Moksa, Michelle, Mingay, Matthew, Hussainkhel, Angela, Davis, Brad, Nagarajan, Raman P., Hong, Chibo, Echipare, Lorigail, O’Geen, Henriette, Hangauer, Matthew J., Cheng, Jeffrey B., Neel, Dana, Hu, Donglei, McManus, Michael T., Moore, Richard, Mungall, Andrew, Ma, Yussanne, Plettner, Patrick, Ziv, Elad, Wang, Ting, Farnham, Peggy J., Jones, Steven J.M., Marra, Marco A., Tlsty, Thea D., Costello, Joseph F., Hirst, Martin

“…While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively little is known…”
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CRISPR‐based environmental DNA detection for a rare endangered estuarine species by Nagarajan, Raman P., Sanders, Leigh, Kolm, Natalie, Perez, Alejandro, Senegal, Taylor, Mahardja, Brian, Baerwald, Melinda R., Schreier, Andrea D.

“…Environmental DNA (eDNA) methods complement traditional aquatic monitoring surveys and are especially advantageous for rare and listed species to detect…”
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Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism by Swanberg, Susan E., Nagarajan, Raman P., Peddada, Sailaja, Yasui, Dag H., LaSalle, Janine M.

“…Mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2), cause the neurodevelopmental disorder Rett syndrome (RTT). Although MECP2 mutations are rare…”
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MECP2 promoter methylation and X chromosome inactivation in autism by Nagarajan, Raman P., Patzel, Katherine A., Martin, Michelle, Yasui, Dag H., Swanberg, Susan E., Hertz-Picciotto, Irva, Hansen, Robin L., Van de Water, Judy, Pessah, Isaac N., Jiang, Ruby, Robinson, Wendy P., LaSalle, Janine M.

“…Epigenetic mechanisms have been proposed to play a role in the etiology of autism. This hypothesis is supported by the discovery of increased MECP2 promoter…”
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Rapid and accurate species identification for ecological studies and monitoring using CRISPR‐based SHERLOCK by Baerwald, Melinda R., Goodbla, Alisha M., Nagarajan, Raman P., Gootenberg, Jonathan S., Abudayyeh, Omar O., Zhang, Feng, Schreier, Andrea D.

“…One of the most fundamental aspects of ecological research and monitoring is accurate species identification, but cryptic speciation and observer error can…”
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Migration‐related phenotypic divergence is associated with epigenetic modifications in rainbow trout by Baerwald, Melinda R., Meek, Mariah H., Stephens, Molly R., Nagarajan, Raman P., Goodbla, Alisha M., Tomalty, Katharine M. H., Thorgaard, Gary H., May, Bernie, Nichols, Krista M.

“…Migration is essential for the reproduction and survival of many animals, yet little is understood about its underlying molecular mechanisms. We used the…”
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Conserved role of intragenic DNA methylation in regulating alternative promoters by Maunakea, Alika K., Nagarajan, Raman P., Bilenky, Mikhail, Ballinger, Tracy J., D’Souza, Cletus, Fouse, Shaun D., Johnson, Brett E., Hong, Chibo, Nielsen, Cydney, Zhao, Yongjun, Turecki, Gustavo, Delaney, Allen, Varhol, Richard, Thiessen, Nina, Shchors, Ksenya, Heine, Vivi M., Rowitch, David H., Xing, Xiaoyun, Fiore, Chris, Schillebeeckx, Maximiliaan, Jones, Steven J. M., Haussler, David, Marra, Marco A., Hirst, Martin, Wang, Ting, Costello, Joseph F.

“…Methylation in the genes DNA methylation plays an important role in the maintenance of cell identity through its effect on gene expression. Methylation of 5′…”
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Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm by Zhang, Bo, Zhou, Yan, Lin, Nan, Lowdon, Rebecca F, Hong, Chibo, Nagarajan, Raman P, Cheng, Jeffrey B, Li, Daofeng, Stevens, Michael, Lee, Hyung Joo, Xing, Xiaoyun, Zhou, Jia, Sundaram, Vasavi, Elliott, Ginell, Gu, Junchen, Shi, Taoping, Gascard, Philippe, Sigaroudinia, Mahvash, Tlsty, Thea D, Kadlecek, Theresa, Weiss, Arthur, O'Geen, Henriette, Farnham, Peggy J, Maire, Cécile L, Ligon, Keith L, Madden, Pamela A F, Tam, Angela, Moore, Richard, Hirst, Martin, Marra, Marco A, Zhang, Baoxue, Costello, Joseph F, Wang, Ting

“…DNA methylation plays key roles in diverse biological processes such as X chromosome inactivation, transposable element repression, genomic imprinting, and…”
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Genome-scale DNA methylation analysis by Fouse, Shaun D, Nagarajan, Raman O, Costello, Joseph F

“…The haploid human genome contains approximately 29 million CpGs that exist in a methylated, hydroxymethylated or unmethylated state, collectively referred to…”
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Molecular Epigenetics and Genetics in Neuro-Oncology by Nagarajan, Raman P., Costello, Joseph F.

“…Gliomas arise through genetic and epigenetic alterations of normal brain cells, although the exact cell of origin for each glioma subtype is unknown. The…”
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Recurrent epimutations activate gene body promoters in primary glioblastoma by Nagarajan, Raman P, Zhang, Bo, Bell, Robert J A, Johnson, Brett E, Olshen, Adam B, Sundaram, Vasavi, Li, Daofeng, Graham, Ashley E, Diaz, Aaron, Fouse, Shaun D, Smirnov, Ivan, Song, Jun, Paris, Pamela L, Wang, Ting, Costello, Joseph F

“…Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly…”
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Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders by Samaco, Rodney C., Nagarajan, Raman P., Braunschweig, Daniel, LaSalle, Janine M.

“…Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Although MECP2 is…”
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Epigenomic programming in early fetal brain development by Li, Luolan, Maire, Cecile L, Bilenky, Misha, Carles, Annaïck, Heravi-Moussavi, Alireza, Hong, Chibo, Tam, Angela, Kamoh, Baljit, Cho, Stephanie, Cheung, Dorothy, Li, Irene, Wong, Tina, Nagarajan, Raman P, Mungall, Andrew J, Moore, Richard, Wang, Ting, Kleinman, Claudia L, Jabado, Nada, Jones, Steven Jm, Marra, Marco A, Ligon, Keith L, Costello, Joseph F, Hirst, Martin

“…To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation…”
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Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4 by Nagarajan, Raman P., Zhang, Jingming, Li, Wei, Chen, Yan

“…Smad7 is a regulatory Smad protein that is able to antagonize signal transduction by transforming growth factor-β (TGF-β) and activin receptors. To…”
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Methods for cancer epigenome analysis by Nagarajan, Raman P, Fouse, Shaun D, Bell, Robert J A, Costello, Joseph F

“…Accurate detection of epimutations in tumor cells is crucial for -understanding the molecular pathogenesis of cancer. Alterations in DNA methylation in cancer…”
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