Search Results - "Nagarajan, Arvindhan"

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression by Nagarajan, Arvindhan, Malvi, Parmanand, Wajapeyee, Narendra

“…Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free,…”
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Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression by Malvi, Parmanand, Janostiak, Radoslav, Nagarajan, Arvindhan, Cai, Guoping, Wajapeyee, Narendra

“…Metabolic alterations that are critical for cancer cell growth and metastasis are one of the key hallmarks of cancer. Here, we show that thymidine kinase 1…”
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N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production by Malvi, Parmanand, Janostiak, Radoslav, Nagarajan, Arvindhan, Zhang, Xuchen, Wajapeyee, Narendra

“…Metabolic deregulation is a key hallmark of cancer cells and has been shown to drive cancer growth and metastasis. However, not all metabolic drivers of…”
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Advances in genome-wide DNA methylation analysis by Gupta, Romi, Nagarajan, Arvindhan, Wajapeyee, Narendra

“…The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has emerged as an important epigenetic mark most commonly present in the…”
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MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels by Nagarajan, Arvindhan, Petersen, Max C., Nasiri, Ali R., Butrico, Gina, Fung, Annie, Ruan, Hai-Bin, Kursawe, Romy, Caprio, Sonia, Thibodeau, Jacques, Bourgeois-Daigneault, Marie-Claude, Sun, Lisha, Gao, Guangping, Bhanot, Sanjay, Jurczak, Michael J., Green, Michael R., Shulman, Gerald I., Wajapeyee, Narendra

“…Insulin resistance is a key driver of type 2 diabetes (T2D) and is characterized by defective insulin receptor (INSR) signalling. Although surface INSR…”
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Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells by Forloni, Matteo, Gupta, Romi, Nagarajan, Arvindhan, Sun, Li-Sha, Dong, Yuying, Pirazzoli, Valentina, Toki, Maria, Wurtz, Anna, Melnick, Mary Ann, Kobayashi, Susumu, Homer, Robert J., Rimm, David L., Gettinger, Scott J., Politi, Katerina, Dogra, Shaillay Kumar, Wajapeyee, Narendra

“…Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of…”
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DNA Transfection Mediated by Cationic Lipid Reagents by Kumar, Priti, Nagarajan, Arvindhan, Uchil, Pradeep D

“…Liposomal transfection reagents vary in their ability to transfect cell lines efficiently. Some are generalists, whereas others are best used with specific…”
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Differentially evolved genes of Salmonella pathogenicity islands: insights into the mechanism of host specificity in Salmonella by Eswarappa, Sandeepa M, Janice, Jessin, Nagarajan, Arvindhan G, Balasundaram, Sudhagar V, Karnam, Guruswamy, Dixit, Narendra M, Chakravortty, Dipshikha

“…The species Salmonella enterica (S. enterica) includes many serovars that cause disease in avian and mammalian hosts. These serovars differ greatly in their…”
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lac repressor is an antivirulence factor of Salmonella enterica: its role in the evolution of virulence in Salmonella by Eswarappa, Sandeepa M, Karnam, Guruswamy, Nagarajan, Arvindhan G, Chakraborty, Sangeeta, Chakravortty, Dipshikha

“…The genus Salmonella includes many pathogens of great medical and veterinary importance. Bacteria belonging to this genus are very closely related to those…”
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Analysis of Cell Viability by the MTT Assay by Kumar, Priti, Nagarajan, Arvindhan, Uchil, Pradeep D

“…Among viability assays that depend on the conversion of substrate to chromogenic product by live cells, the MTT assay is still among one of the most versatile…”
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A safe vaccine (DV-STM-07) against Salmonella infection prevents abortion and confers protective immunity to the pregnant and new born mice by Negi, Vidya Devi, Nagarajan, Arvindhan G, Chakravortty, Dipshikha

“…Pregnancy is a transient immuno-compromised condition which has evolved to avoid the immune rejection of the fetus by the maternal immune system. The altered…”
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TolA mediates the differential detergent resistance pattern between the Salmonella enterica subsp. enterica serovars Typhi and Typhimurium by Lahiri, Amit, Ananthalakshmi, T K, Nagarajan, Arvindhan G, Ray, Seemun, Chakravortty, Dipshikha

“…The tol-pal genes are essential for maintaining the outer membrane integrity and detergent resistance in various Gram-negative bacteria, including Salmonella…”
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sopB of Salmonella enterica serovar Typhimurium is a potential DNA vaccine candidate in conjugation with live attenuated bacteria by Nagarajan, Arvindhan G, Balasundaram, Sudhagar V, Janice, Jessin, Karnam, Guruswamy, Eswarappa, Sandeepa M, Chakravortty, Dipshikha

“…Abstract The immune response against Salmonella is multi-faceted involving both the innate and the adaptive immune system. The characterization of specific…”
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Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins by Wajapeyee, Narendra, Wang, Shu-Zong, Serra, Ryan W., Solomon, Peter D., Nagarajan, Arvindhan, Zhu, Xiaochun, Green, Michael R.

“…Hematologic malignancies are typically associated with leukemogenic fusion proteins, which are required to maintain the oncogenic state. Previous studies have…”
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Reliable Means of Diagnosis and Serovar Determination of Blood-Borne Salmonella Strains: Quick PCR Amplification of Unique Genomic Loci by Novel Primer Sets by Nagarajan, Arvindhan Govindasamy, Karnam, Guruswamy, Lahiri, Amit, Allam, Uday Sankar, Chakravortty, Dipshikha

“…Typhoid fever is becoming an ever increasing threat in the developing countries. We have improved considerably upon the existing PCR-based diagnosis method by…”
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Oncogene-directed alterations in cancer cell metabolism by Nagarajan, Arvindhan, Malvi, Parmanand, Wajapeyee, Narendra

“…Oncogenes are key drivers of tumor growth. Although several cancer-driving mechanisms have been identified, the role of oncogenes in shaping metabolic patterns…”
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Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport by Nagarajan, Arvindhan, Dogra, Shaillay Kumar, Sun, Lisha, Gandotra, Neeru, Ho, Thuy, Cai, Guoping, Cline, Gary, Kumar, Priti, Cowles, Robert A., Wajapeyee, Narendra

“…Metabolic deregulation is a hallmark of human cancers, and the glycolytic and glutamine metabolism pathways were shown to be deregulated in pancreatic ductal…”
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Genome Wide siRNA Screen Identifies CGAS-Sting Pathway As a Pharmacological Target That Promotes Survival of Hematopoietic Stem Cells Deficient in Fanconi Genes by Nagarajan, Arvindhan G., Neeley, Nicholas, Doroodian, Paymon, Olazabel, Ane, Kupfer, Gary

“…Introduction Fanconi anemia (FA) is a homozygous recessive genetic disorder due to mutation in the Fanconi family of genes. The disease is characterized by…”
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Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase Activity by Liang, Fengshan, Nagarajan, Arvindhan, Pillai, Manoj M, Sung, Patrick, Kupfer, Gary M.

“…Background: Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure, developmental defects, and higher risk of cancer. Mutations in FA…”
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Lipofection by Kumar, Priti, Nagarajan, Arvindhan, Uchil, Pradeep D

“…In the past, cloned DNA was introduced into cultured eukaryotic cells chiefly by biochemical methods using either calcium phosphate or diethylaminoethyl…”
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