Search Results - "Nagaraja, Omantheswara"

Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells by Kim, Na Young, Vishwanath, Divakar, Xi, Zhang, Nagaraja, Omantheswara, Swamynayaka, Ananda, Kumar Harish, Keshav, Basappa, Shreeja, Madegowda, Mahendra, Pandey, Vijay, Sethi, Gautam, Lobie, Peter E, Ahn, Kwang Seok, Basappa, Basappa

“…Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a…”
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Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells by Deveshegowda, Suresha N, Metri, Prashant K, Shivakumar, Rashmi, Yang, Ji-Rui, Rangappa, Shobith, Swamynayaka, Ananda, Shanmugam, Muthu K, Nagaraja, Omantheswara, Madegowda, Mahendra, Babu Shubha, Priya, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Ahn, Kwang Seok, Lobie, Peter E, Basappa, Basappa

“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
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Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells by Kim, Na Young, Dukanya, Dukanya, Sethi, Gautam, Girimanchanaika, Swamy S, Yang, Jirui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Vishwanath, Divakar, Venkantesha, Keerthikumara, Basappa, Shreeja, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Madegowda, Mahendra, Sukhorukov, Alexey, Pandey, Vijay, Lobie, Peter E., Basappa, Basappa, Ahn, Kwang Seok

“…•To overcome drug-resistant breast cancer, it is essential to develop compounds that induce apoptosis and paraptosis.•BSO-07 triggered G1 phase arrest, cleaved…”
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Nano-ZrO2-Catalyzed Biginelli Reaction and the Synthesis of Bioactive Dihydropyrimidinones That Targets PPAR-γ in Human Breast Cancer Cells by Suresha N. Deveshegowda, Ji-Rui Yang, Zhang Xi, Omantheswara Nagaraja, Kashifa Fazl-Ur-Rahman, Bhanuprakash C. Narasimhachar, Gautam Sethi, Ganga Periyasamy, Mahendra Madegowda, Shobith Rangappa, Vijay Pandey, Peter E. Lobie, Basappa Basappa

“…Bioactive dihydropyrimidinones (DHPs) were designed and synthesized by a multicomponent Biginelli reaction. The reaction was catalyzed by the polarized surface…”
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De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells by Ravish, Akshay, Shivakumar, Rashmi, Xi, Zhang, Yang, Min Hee, Yang, Ji-Rui, Swamynayaka, Ananda, Nagaraja, Omantheswara, Madegowda, Mahendra, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Sethi, Gautam, Ahn, Kwang Seok, Lobie, Peter E, Basappa, Basappa

“…In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for…”
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Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells by Basappa, Basappa, Poonacha, Lisha K, Xi, Zhang, Vishwanath, Divakar, Yang, Ji-Rui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Madegowda, Mahendra, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Gurudatt, Doddahosuru Mahadevappa, Pandey, Vijay, Shivananju, Nanjundaswamy, Ahn, Kwang Seok, Sethi, Gautam, Lobie, Peter E, Shubha, Priya Babu

“…Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer…”
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Studies on New Imidazo[2,1-b][1,3,4]thiadiazole Derivatives: Molecular Structure, Quantum Chemical Computational, and In silico Study of Inhibitory Activity Against Pim-1 Protein by using Molecular Modelling Methods and ADMET Profiling by Khamees, Hussien Ahmed, Srinivas, Mahesh Sankanahalli, Nagaraja, Omantheswara, Madegowda, Mahendra, M, Vindu Vahini, Chaluvaiah, Kumara, Dasappa, Jagadeesh Prasad, Warad, Ismail

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Pyrimidine-triazole-tethered tert-butyl-piperazine-carboxylate suppresses breast cancer by targeting estrogen receptor signaling and β-catenin activation by Yuan, Jie, Yang, Li, Li, Zhi, Zhang, Hua, Wang, Qun, Wang, Bei, Chinnathambi, Arunachalam, Govindasamy, Chandramohan, Basappa, Shreeja, Nagaraja, Omantheswara, Madegowda, Mahendra, Beeraka, Narasimha M, Nikolenko, Vladimir N, Wang, Minghua, Wang, Geng, Rangappa, Kanchugarakoppal S, Basappa, Basappa

“…Several chemotherapeutics against breast cancer are constrained by their adverse effects and chemoresistance. The development of novel chemotherapeutics to…”
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A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway by Yang, Min Hee, Basappa, Basappa, Deveshegowda, Suresha N., Ravish, Akshay, Mohan, Arunkumar, Nagaraja, Omantheswara, Madegowda, Mahendra, Rangappa, Kanchugarakoppal S., Deivasigamani, Amudha, Pandey, Vijay, Lobie, Peter E., Hui, Kam Man, Sethi, Gautam, Ahn, Kwang Seok

“…[Display omitted] •CHL-C can reduce cell viability in a range of CRC.•CHL-C induces both apoptosis and autophagy in HCT-116 and SW480 cells.•In silico docking…”
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Development of Novel Pyridine and Pyrimidine Clubbed Bisindoles as Inhibitors of AKT Pathway by Poonacha, Lisha K., Metri, Prashant K, Xi, Zhang, Ravish, Akshay, Nagaraja, Omantheswara, Kumar, Arun M., Parameshwaraiah, Sindhu M., Swamy Shivananju, Nanjunda, Madegowda, Mahendra, Lobie, Peter E., Babu Shubha, Priya, Pandey, Vijay, Basappa, Basappa

“…Indoles and their derivatives have long been studied for their anticancer properties. Breast cancer has been treated using indole‐3‐carbinol, Indirubins, and…”
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