Search Results - "Nagaraj, Vini"

Single Nucleotide Polymorphism in Cell Adhesion Molecule L1 Affects Learning and Memory in a Mouse Model of Traumatic Brain Injury by Jiang, Haoyu, Giarratana, Anna O, Theis, Thomas, Nagaraj, Vini, Zhou, Xiaofeng, Thakker-Varia, Smita, Schachner, Melitta, Alder, Janet

“…The L1 cell adhesion molecule (L1) has demonstrated a range of beneficial effects in animal models of spinal cord injury, neurodegenerative disease, and…”
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Reactive Oxygen Species and Pressure Ulcer Formation after Traumatic Injury to Spinal Cord and Brain by Kumar, Suneel, Theis, Thomas, Tschang, Monica, Nagaraj, Vini, Berthiaume, Francois

“…Traumatic injuries to the nervous system, including the brain and spinal cord, lead to neurological dysfunction depending upon the severity of the injury. Due…”
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Autism Spectrum Disorders: A Recent Update on Targeting Inflammatory Pathways with Natural Anti-Inflammatory Agents by Singh, Ramu, Kisku, Anglina, Kungumaraj, Haripriya, Nagaraj, Vini, Pal, Ajay, Kumar, Suneel, Sulakhiya, Kunjbihari

“…Autism spectrum disorder (ASD) is a heterogeneous category of developmental psychiatric disorders which is characterized by inadequate social interaction, less…”
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Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes by Rosengren, Anders H, Jokubka, Ramunas, Tojjar, Damon, Granhall, Charlotte, Hansson, Ola, Li, Dai-Qing, Nagaraj, Vini, Reinbothe, Thomas M, Tuncel, Jonatan, Eliasson, Lena, Groop, Leif, Rorsman, Patrik, Salehi, Albert, Lyssenko, Valeriya, Luthman, Holger, Renström, Erik

“…Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic…”
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Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth by Nagaraj, Vini, Theis, Thomas, Johal, Anmol Singh, Seth, Arihant, Gore, Jada, Arsha, Neha, Patel, Mukti, Hao, Helen Baixia, Kurian, Nikki, Schachner, Melitta

“…Nogo-A, a glycoprotein expressed in oligodendrocytes and central nervous system myelin, inhibits regeneration after injury. Antibodies against Nogo-A…”
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The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events by Krus, Ulrika, King, Ben C., Nagaraj, Vini, Gandasi, Nikhil R., Sjölander, Jonatan, Buda, Pawel, Garcia-Vaz, Eliana, Gomez, Maria F., Ottosson-Laakso, Emilia, Storm, Petter, Fex, Malin, Vikman, Petter, Zhang, Enming, Barg, Sebastian, Blom, Anna M., Renström, Erik

“…Type 2 diabetes is triggered by reduced insulin production, caused by genetic and environmental factors such as inflammation originating from the innate immune…”
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Antagonistic L1 Adhesion Molecule Mimetic Compounds Inhibit Glioblastoma Cell Migration In Vitro by Nagaraj, Vini, Mikhail, Mirai, Baronio, Micol, Gatto, Alessia, Nayak, Ashana, Theis, Thomas, Cavallaro, Ugo, Schachner, Melitta

“…Cell adhesion molecule L1 is a cell surface glycoprotein that promotes neuronal cell migration, fosters regeneration after spinal cord injury and ameliorates…”
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CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion by Abels, Mia, Riva, Matteo, Bennet, Hedvig, Ahlqvist, Emma, Dyachok, Oleg, Nagaraj, Vini, Shcherbina, Liliya, Fred, Rikard G., Poon, Wenny, Sörhede-Winzell, Maria, Fadista, Joao, Lindqvist, Andreas, Kask, Lena, Sathanoori, Ramasri, Dekker-Nitert, Marloes, Kuhar, Michael J., Ahrén, Bo, Wollheim, Claes B., Hansson, Ola, Tengholm, Anders, Fex, Malin, Renström, Erik, Groop, Leif, Lyssenko, Valeriya, Wierup, Nils

“…Aims/hypothesis Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART,…”
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Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression by Vallois, David, Niederhäuser, Guy, Ibberson, Mark, Nagaraj, Vini, Nagaray, Vini, Marselli, Lorella, Marchetti, Piero, Chatton, Jean-Yves, Thorens, Bernard

“…Gluco-incretin hormones increase the glucose competence of pancreatic beta-cells by incompletely characterized mechanisms. We searched for genes that were…”
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Eukaryotic translation initiation factor 3 subunit e controls intracellular calcium homeostasis by regulation of cav1.2 surface expression by Buda, Pawel, Reinbothe, Thomas, Nagaraj, Vini, Mahdi, Taman, Luan, Cheng, Tang, Yunzhao, Axelsson, Annika S, Li, Daiqing, Rosengren, Anders H, Renström, Erik, Zhang, Enming

“…Inappropriate surface expression of voltage-gated Ca(2+)channels (CaV) in pancreatic ß-cells may contribute to the development of type 2 diabetes. First,…”
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Effects of L1 adhesion molecule agonistic mimetics on signal transduction in neuronal functions by Nagaraj, Vini, Kim, Roy, Martianou, Talia, Kurian, Shyam, Nayak, Ashana, Patel, Mukti, Schachner, Melitta, Theis, Thomas

“…The L1 cell adhesion molecule plays an essential role in neural development and repair. It is not only a ‘lock and key’ recognition molecule, but an important…”
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Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, but not in the Hippocampus, Is Essential for Antidepressant-Like Effects of Electroconvulsive Therapy by Taliaz, Dekel, Nagaraj, Vini, Haramati, Sharon, Chen, Alon, Zangen, Abraham

“…Background Impaired neuronal plasticity and, specifically, altered expression of brain-derived neurotrophic factor (BDNF) were shown to play a critical role in…”
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Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome by Efthymiou, Stephanie, Scala, Marcello, Nagaraj, Vini, Ochenkowska, Katarzyna, Komdeur, Fenne L, Liang, Robin A, Abdel-Hamid, Mohamed S, Sultan, Tipu, Barøy, Tuva, Van Ghelue, Marijke, Vona, Barbara, Maroofian, Reza, Zafar, Faisal, Alkuraya, Fowzan S, Zaki, Maha S, Severino, Mariasavina, Duru, Kingsley C, Tryon, Robert C, Brauteset, Lin Vigdis, Ansari, Morad, Hamilton, Mark, van Haelst, Mieke M, van Haaften, Gijs, Zara, Federico, Houlden, Henry, Samarut, Éric, Nichols, Colin G, Smeland, Marie F, McClenaghan, Conor

“…Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal…”
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Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol by Nagaraj, Vini, Kazim, Abdulla S, Helgeson, Johan, Lewold, Clemens, Barik, Satadal, Buda, Pawel, Reinbothe, Thomas M, Wennmalm, Stefan, Zhang, Enming, Renström, Erik

“…Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes,…”
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Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion by Nagaraj, Vini, King, Ben, Storm, Petter, Vikman, Petter, Ottosson-Laakso, Emilia, Blom, Anna M., Renström, Erik

“…CD55 is a glycosylphosphatidylinositol-anchored protein, which inhibits complement activation by acting on the complement C3 convertases. CD55 is widely…”
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CD59 is required for pancreatic beta cell insulin exocytosis by Krus, Ulrika, King, Benjamin C., Nagaraj, Vini, Gandasi, Nikhil, Sjolander, Jonatan, Buda, Pawel, Garcia-Vaz, Eliana, Gomez, Maria, Ottosson-Laakso, Emilia, Storm, Petter, Fex, Malin, Vikman, Petter, Zhang, Enming, Barg, Sebastian, Blom, Anna M., Renstrom, Erik

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Complement receptor C5aR is expressed in pancreatic islets and affects glucose-induced insulin and glucagon secretion by Nagaraj, Vini, Krus, Ulrika, Blom, Anna, Renström, Erik

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Complement factors are expressed in pancreatic islets and affect glucose induced insulin secretion by Nagaraj, Vini, Krus, Ulrika, Sjölander, Jonatan, Blom, Anna, Renström, Erik

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