Search Results - "Nagaraj, Ramakrishnan"

In silico folding of hydrophobic peptides that form β‐hairpin structures in solution by Moharana, Tushar Ranjan, Nagaraj, Ramakrishnan

“…Peptides designed with residues that have a high propensity to occur in β‐turns form β‐hairpin structures in apolar as well as in polar organic solvents such…”
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Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing by Mathew, Basil, Nagaraj, Ramakrishnan

“…Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that…”
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Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity by Sharma, Himanshu, Nagaraj, Ramakrishnan

“…Human defensins play multiple roles in innate immunity including direct antimicrobial killing and immunomodulatory activity. They have three disulfide bridges…”
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A proteomic perspective and involvement of cytokines in SARS-CoV-2 infection by Banu, Sarena, Nagaraj, Ramakrishnan, Idris, Mohammed M

“…Infection with the SARS-CoV-2 virus results in manifestation of several clinical observations from asymptomatic to multi-organ failure. Biochemically, the…”
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Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection by Enayathullah, Mohammed Ghalib, Parekh, Yash, Banu, Sarena, Ram, Sushma, Nagaraj, Ramakrishnan, Kumar, Bokara Kiran, Idris, Mohammed M.

“…The COVID19 pandemic has led to multipronged approaches for treatment of the disease. Since de novo discovery of drugs is time consuming, repurposing of…”
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Defensins: Therapeutic molecules with potential to treat SARS-CoV-2 infection by Banu, Sarena, Nagaraj, Ramakrishnan, Idris, Mohammed

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Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3 by Krishnakumari, Viswanatha, Rangaraj, Nandini, Nagaraj, Ramakrishnan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Self-Assembly of Aβ40, Aβ42 and Aβ43 Peptides in Aqueous Mixtures of Fluorinated Alcohols by Pachahara, Sanjai Kumar, Adicherla, Harikrishna, Nagaraj, Ramakrishnan

“…Fluorinated alcohols such as hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have the ability to promote α-helix and β-hairpin structure in proteins…”
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Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins by Olli, Sudar, Rangaraj, Nandini, Nagaraj, Ramakrishnan

“…We have examined the antimicrobial activity of C-terminal analogs of human β-defensins HBD-1 and-3 wherein lysines have been selectively replaced by L- and…”
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Peptide self-assembly: from toxins to amyloid fibrils and nanotubes by Rawat, Anoop, Nagaraj, Ramakrishnan

“…The process of self-assembly is universal and lies at the heart of biological structures and function. Peptide aggregation, while considered a nuisance in…”
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Formation of Nanostructures by Peptides by Pachahara, Sanjai Kumar, Subbalakshmi, Chivukula, Nagaraj, Ramakrishnan

“…Amyloid fibrils, which are implicated in several diseases, are highly ordered structures formed by aggregation of proteins. Intriguingly, several short…”
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Antibacterial Activity of Human Neutrophil Defensin HNP-1 Analogs without Cysteines by VARKEY, Jobin, NAGARAJ, Ramakrishnan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Determinants of membrane association in the SH4 domain of Fyn: Roles of N-terminus myristoylation and side-chain thioacylation by Rawat, Anoop, Nagaraj, Ramakrishnan

“…The SH4 domain of Fyn, a member of the Src family of tyrosine kinases, though rich in polar amino acid residues, anchors to the cytosolic face of membranes…”
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Escherichia coli Lipopolysaccharide Modulates Biological Activities of Human-β-Defensin Analogues but Not Non-Ribosomally Synthesized Peptides by Krishnakumari, Viswanatha, Binny, Taniya Mary, Adicherla, Harikrishna, Nagaraj, Ramakrishnan

“…Human-β-defensins (HBD1-3) are antibacterial peptides containing three disulphide bonds. In the present study, the effect of Escherichia coli…”
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Self‐assembly of β‐turn motif‐connected tandem repeats of Aβ16‐22 and its aromatic analogs by Datta, Debika, Harikrishna, Adicherla, Nagaraj, Ramakrishnan, Chaudhary, Nitin

“…Self‐assembly of peptides and proteins into aggregates with a signature of cross‐β conformation is a hallmark of amyloids. Short peptides have provided…”
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Hydrogel Formation by an Aromatic Analogue of a β‑Amyloid Fragment, Aβ16–22: A Scaffold for 3D Cell Culture by Datta, Debika, Kumar, Vishnu, Kumar, Sachin, Nagaraj, Ramakrishnan, Chaudhary, Nitin

“…A short 7-residue stretch from β-amyloid, Aβ16–22 (Ac-KLVFFAE-am), yields typical amyloid-like fibrils at neutral pH. The Phe–Phe cassette present in the…”
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Analysis of human blood plasma proteome from ten healthy volunteers from Indian population by Gautam, Poonam, Nair, Sudha C, Ramamoorthy, Kalidoss, Swamy, Cherukuvada V Brahmendra, Nagaraj, Ramakrishnan

“…Analysis of any mammalian plasma proteome is a challenge, particularly by mass spectrometry, due to the presence of albumin and other abundant proteins which…”
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Dysfunction of store-operated calcium channel in muscle cells lacking mg29 by Ma, Jianjie, Pan, Zui, Yang, Dongmei, Nagaraj, Ramakrishnan Y, Nosek, Thomas A, Nishi, Miyuki, Takeshima, Hiroshi, Cheng, Heping

“…The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of…”
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Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides by Bera, Ananya, Singh, Shashi, Nagaraj, Ramakrishnan, Vaidya, Tushar

“…We demonstrate that antimicrobial peptides induce an autophagic cell death in the protozoan pathogen, Leishmania donovani. In our study, three antimicrobial…”
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Morphology of self-assembled structures formed by short peptides from the amyloidogenic protein tau depends on the solvent in which the peptides are dissolved by Chaudhary, Nitin, Singh, Shashi, Nagaraj, Ramakrishnan

“…The aggregation behavior of peptides Ac‐VQIVYK‐amide (AcPHF6) and Ac‐QIVYK‐amide (AcPHF5) from the amyloidogenic protein tau was examined by atomic force…”
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