Search Results - "Nagao, Minako"

Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish by Sugimura, Takashi, Wakabayashi, Keiji, Nakagama, Hitoshi, Nagao, Minako

“…Research leading to the discovery of a series of mutagenic and carcinogenic heterocyclic amines (HCAs) was inspired by the idea that smoke produced during…”
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Cancer in Japan: Prevalence, prevention and the role of heterocyclic amines in human carcinogenesis by Nagao, Minako, Tsugane, Shoichiro

“…In this article, three topics are being studied in order to understand the present state of cancer in Japan. First, the statistics on cancer mortality…”
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Unfolding of Quadruplex Structure in the G-Rich Strand of the Minisatellite Repeat by the Binding Protein UP1 by Fukuda, Hirokazu, Katahira, Masato, Tsuchiya, Naoto, Enokizono, Yoshiaki, Sugimura, Takashi, Nagao, Minako, Nakagama, Hitoshi

“…The mouse hypervariable minisatellite (MN) Pc-1 consists of tandem repeats of d(GGCAG) and flanked sequences. We have previously demonstrated that…”
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Attractin/Mahogany/Zitter Plays a Critical Role in Myelination of the Central Nervous System by Kuramoto, Takashi, Kitada, Kazuhiro, Inui, Toshihide, Sasaki, Yoshifumi, Ito, Kazumi, Hase, Takao, Kawagachi, Saburo, Ogawa, Yoshihiro, Nakao, Kazuwa, Barsh, Gregory S., Nagao, Minako, Ushijima, Toshikazu, Serikawa, Tadao

“…The rat zitter (zi) mutation induces hypomyelination and vacuolation in the central nervous system (CNS), which result in early-onset tremor and progressive…”
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Establishment of Methylation-Sensitive-Representational Difference Analysis and Isolation of Hypo- and Hypermethylated Genomic Fragments in Mouse Liver Tumors by Ushijima, Toshikazu, Morimura, Keiichirou, Hosoya, Yoko, Okonogi, Hideo, Tatematsu, Masae, Sugimura, Takashi, Nagao, Minako

“…Methylation of CpG sites in the genome, which is generally conserved during cell replication, is considered to play important roles in cell differentiation and…”
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Characterization of Dysplastic Aberrant Crypt Foci in the Rat Colon Induced by 2-Amino-1-Methyl-6-Phenylimidazo[4,5- b]Pyridine by Ochiai, Masako, Ushigome, Mitsunori, Fujiwara, Kyoko, Ubagai, Tsuneyuki, Kawamori, Toshihiko, Sugimura, Takashi, Nagao, Minako, Nakagama, Hitoshi

“…The multistage model of colon carcinogenesis is well established in both humans and experimental animals, and aberrant crypt foci (ACF) are generally assumed…”
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Effect of Chlorophyllin-Chitosan on Excretion of Dioxins in a Healthy Man by Kitamura, Kimiyoshi, Nagao, Minako, Hayatsu, Hikoya, Morita, Masatoshi

“…We investigated the usefulness of chitosan and chlorophyllin-chitosan (chl-chitosan) administration for reduction of the body burden of environmental dioxins,…”
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Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by Fujiwara, Kyoko, Ochiai, Masako, Ohta, Tsutomu, Ohki, Misao, Aburatani, Hiroyuki, Nagao, Minako, Sugimura, Takashi, Nakagama, Hitoshi

“…Colon cancers develop after accumulation of multiple genetic and epigenetic alterations in colon epithelial cells. To shed light on global changes in gene…”
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Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine by Okochi, Eriko, Watanabe, Naoko, Shimada, Yoshiya, Takahashi, Satoru, Wakazono, Kuniko, Shirai, Tomoyuki, Sugimura, Takashi, Nagao, Minako, Ushijima, Toshikazu

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is known to induce a characteristic mutation, G deletion at the 5′-GGGA-3′ site, preferentially in the…”
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Prevention of heterocyclic amine formation by tea and tea polyphenols by Weisburger, J H, Nagao, M, Wakabayashi, K, Oguri, A

“…Heterocyclic amines (HCAs), formed during the cooking of meats and fish, are thought to be the genotoxic carcinogens associated with important types of human…”
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Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats by Hasegawa, R, Hirose, M, Kato, T, Hagiwara, A, Boonyaphiphat, P, Nagao, M, Ito, N, Shirai, T

“…Chlorophyll and chlorophyllin, a water-soluble salt of chlorophyll, have been reported to inhibit carcinogen-DNA binding and exert antimutagenic activity for…”
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Induction of Minisatellite Mutation in NIH 3T3 Cells by Treatment with the Tumor Promoter Okadaic Acid by Nakagama, Hitoshi, Kaneko, Shigeto, Shima, Hiroshi, Inamori, Hideaki, Fukuda, Hirokazu, Kominami, Ryo, Sugimura, Takashi, Nagao, Minako

“…Okadaic acid (OA) is a strong tumor promoter of mouse skin carcinogenesis and also a potent inhibitor of serine/threonine protein phosphatases. OA induces…”
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Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat by Fujiwara, Kyoko, Ochiai, Masako, Ubagai, Tsuneyuki, Ohki, Misao, Ohta, Tsutomu, Nagao, Minako, Sugimura, Takashi, Nakagama, Hitoshi

“…Colon cancers develop through accumulation of multiple genetic and epigenetic alterations in colon epithelial cells, and the environment of the genetically…”
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Soy protein isolate enhances hepatic copper accumulation and cell damage in LEC rats by Yonezawa, Kayo, Nunomiya, Sachiko, Daigo, Mitsue, Ogra, Yasumitsu, Suzuki, Kazuo T, Enomoto, Katsuhiko, Nakagama, Hitoshi, Yoshikawa, Kunie, Nagao, Minako

“…In a series of experiments, the effects of soy protein isolate (SPI), defatted soy (DFS) or SPI supplemented with L-methionine (SPIM) were examined in the…”
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Neurofilament-associated protein phosphatase 2A: Its possible role in preserving neurofilaments in filamentous states by Saito, Taro, Shima, Hiroshi, Osawa, Yutaka, Nagao, Minako, Hemmings, Brian A, Kishimoto, Takeo, Hisanaga, Shin-ichi

“…Neurofilament phosphatase (NF-phosphatase) activity, which dephosphorylates NF proteins phosphorylated by cyclic AMP-dependent protein kinase (A-kinase), was…”
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Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food‐borne Carcinogen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine by Ochiai, Masako, Imai, Hiroshi, Sugimura, Takashi, Nagao, Minako, Nakagama, Hitoshi

“…2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) is the most abundant heterocyclic amine contained in cooked meat and fish. Although PhIP has been…”
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DIOXINS IN BILE IN RELATION TO THOSE IN THE HUMAN LIVER AND BLOOD by KITAMURA, Kimiyoshi, NAGAO, Minako, YAMADA, Taketo, SUNAGA, Masahiro, HATA, Jun-ichi, WATANABE, Shaw

“…The levels of 20 dioxin congeners, 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs) and three coplanar polychlorinated…”
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Detection and isolation of minisatellite Pc-1 binding proteins by Fukuda, Hirokazu, Sugimura, Takashi, Nagao, Minako, Nakagama, Hitoshi

“…Minisatellites (MNs) are arrays of 5–100 nucleotide repeats that are dispersed throughout the genome of vertebrates. They demonstrate alteration in tumors and…”
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Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats by Nagao, Minako, Ushijima, Toshikazu, Watanabe, Naoko, Okochi, Eriko, Ochiai, Masako, Nakagama, Hitoshi, Sugimura, Takashi

“…Ten heterocyclic amines (HCAs) that are produced by heating amino acids, proteins, or proteinaceous food such as fish and meat were examined for…”
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Cancer in Japan : Prevalence, prevention and the role of heterocyclic amines in human carcinogenesis by Minako Nagao, Shoichiro Tsugane

“…[Abstract] In this article, three topics are being studied in order to understand the present state of cancer in Japan. First, the statistics on cancer…”
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