Search Results - "Nagano, Osamu"

Mechanism and biological significance of CD44 cleavage by Nagano, Osamu, Saya, Hideyuki

“…There are multiple steps in the metastasis of cancer cells. Tumor cells must first detach from the tumor mass and invade the surrounding extracellular matrix…”
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Comparison of two-stage Gamma Knife radiosurgery outcomes for large brain metastases among primary cancers by Ito, Daisuke, Aoyagi, Kyoko, Nagano, Osamu, Serizawa, Toru, Iwadate, Yasuo, Higuchi, Yoshinori

“…Purpose Stereotactic radiosurgery (SRS) is typically considered for patients who cannot undergo surgical resection for large (> 10 cm 3 ) brain metastases…”
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Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma by Okazaki, Shogo, Umene, Kiyoko, Yamasaki, Juntaro, Suina, Kentaro, Otsuki, Yuji, Yoshikawa, Momoko, Minami, Yushi, Masuko, Takashi, Kawaguchi, Sho, Nakayama, Hideki, Banno, Kouji, Aoki, Daisuke, Saya, Hideyuki, Nagano, Osamu

“…Targeting the function of membrane transporters in cancer stemlike cells is a potential new therapeutic approach. Cystine‐glutamate antiporter xCT expressed in…”
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MEK inhibition suppresses metastatic progression of KRAS‐mutated gastric cancer by Yamasaki, Juntaro, Hirata, Yuki, Otsuki, Yuji, Suina, Kentaro, Saito, Yoshiyuki, Masuda, Kenta, Okazaki, Shogo, Ishimoto, Takatsugu, Saya, Hideyuki, Nagano, Osamu

“…Metastatic progression of tumors is driven by genetic alterations and tumor‐stroma interaction. To elucidate the mechanism underlying the oncogene‐induced…”
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Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells by Tsugawa, Hitoshi, Suzuki, Hidekazu, Saya, Hideyuki, Hatakeyama, Masanori, Hirayama, Toshiya, Hirata, Kenro, Nagano, Osamu, Matsuzaki, Juntaro, Hibi, Toshifumi

“…Sustained expression of CagA, the type IV secretion effector of Helicobacter pylori, is closely associated with the development of gastric cancer. However, we…”
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CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc − and Thereby Promotes Tumor Growth by Ishimoto, Takatsugu, Nagano, Osamu, Yae, Toshifumi, Tamada, Mayumi, Motohara, Takeshi, Oshima, Hiroko, Oshima, Masanobu, Ikeda, Tatsuya, Asaba, Rika, Yagi, Hideki, Masuko, Takashi, Shimizu, Takatsune, Ishikawa, Tomoki, Kai, Kazuharu, Takahashi, Eri, Imamura, Yu, Baba, Yoshifumi, Ohmura, Mitsuyo, Suematsu, Makoto, Baba, Hideo, Saya, Hideyuki

“…CD44 is an adhesion molecule expressed in cancer stem-like cells. Here, we show that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine…”
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Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors by Suzuki, Kazumi, Miura, Yutaka, Mochida, Yuki, Miyazaki, Takuya, Toh, Kazuko, Anraku, Yasutaka, Melo, Vinicio, Liu, Xueying, Ishii, Takehiko, Nagano, Osamu, Saya, Hideyuki, Cabral, Horacio, Kataoka, Kazunori

“…Nanomedicine modification with ligands directed to receptors on tumor blood vessels has the potential for selectively enhancing nanomedicine accumulation in…”
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Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy by Otsuki, Yuji, Yamasaki, Juntaro, Suina, Kentaro, Okazaki, Shogo, Koike, Naoyoshi, Saya, Hideyuki, Nagano, Osamu

“…The major cellular antioxidant glutathione (GSH) protects cancer cells from oxidative damage that can lead to the induction of ferroptosis, an iron‐dependent…”
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Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer by Mizuno, Shodai, Seishima, Ryo, Yamasaki, Juntaro, Hattori, Kaoru, Ogiri, Masayo, Matsui, Shimpei, Shigeta, Kohei, Okabayashi, Koji, Nagano, Osamu, Li, Liang, Kitagawa, Yuko

“…Purpose Angiopoietin-like 4 (ANGPTL4) was recently shown to be associated with cancer progression but little is known about its contribution to cancer…”
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Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells by TAMADA, Mayumi, NAGANO, Osamu, SUEMATSU, Makoto, SAYA, Hideyuki, TATEYAMA, Seiji, OHMURA, Mitsuyo, YAE, Toshifumi, ISHIMOTO, Takatsugu, SUGIHARA, Eiji, ONISHI, Nobuyuki, YAMAMOTO, Takehiro, YANAGAWA, Hiroshi

“…An increased glycolytic flux accompanied by activation of the pentose phosphate pathway (PPP) is implicated in chemoresistance of cancer cells. In this study,…”
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Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell by Yae, Toshifumi, Tsuchihashi, Kenji, Ishimoto, Takatsugu, Motohara, Takeshi, Yoshikawa, Momoko, Yoshida, Go J., Wada, Takeyuki, Masuko, Takashi, Mogushi, Kaoru, Tanaka, Hiroshi, Osawa, Tsuyoshi, Kanki, Yasuharu, Minami, Takashi, Aburatani, Hiroyuki, Ohmura, Mitsuyo, Kubo, Akiko, Suematsu, Makoto, Takahashi, Kazuhisa, Saya, Hideyuki, Nagano, Osamu

“…In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore…”
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Three-institution study on applicability of initial brain metastasis velocity for breast cancer brain metastasis patients undergoing stereotactic radiosurgery by Yamamoto, Masaaki, Serizawa, Toru, Nagano, Osamu, Aoyagi, Kyoko, Higuchi, Yoshinori, Sato, Yasunori, Kasuya, Hidetoshi, Barfod, Bierta E.

“…Purpose This study aimed to validate whether the recently-proposed prognostic grading system, initial brain metastasis velocity (iBMV), is applicable to breast…”
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Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival by Shiota, Megumi, Naya, Masayuki, Yamamoto, Takehiro, Hishiki, Takako, Tani, Takeharu, Takahashi, Hiroyuki, Kubo, Akiko, Koike, Daisuke, Itoh, Mai, Ohmura, Mitsuyo, Kabe, Yasuaki, Sugiura, Yuki, Hiraoka, Nobuyoshi, Morikawa, Takayuki, Takubo, Keiyo, Suina, Kentaro, Nagashima, Hideaki, Sampetrean, Oltea, Nagano, Osamu, Saya, Hideyuki, Yamazoe, Shogo, Watanabe, Hiroyuki, Suematsu, Makoto

“…Gold deposition with diagonal angle towards boehmite-based nanostructure creates random arrays of horse-bean-shaped nanostructures named gold-nanofève (GNF)…”
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Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells by Okazaki, Shogo, Shintani, Subaru, Hirata, Yuki, Suina, Kentaro, Semba, Takashi, Yamasaki, Juntaro, Umene, Kiyoko, Ishikawa, Miyuki, Saya, Hideyuki, Nagano, Osamu

“…The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer…”
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Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma by Sato, Takashi, Yoo, Seungyeul, Kong, Ranran, Sinha, Abhilasha, Chandramani-Shivalingappa, Prashanth, Patel, Ayushi, Fridrikh, Maya, Nagano, Osamu, Masuko, Takashi, Beasley, Mary Beth, Powell, Charles A, Zhu, Jun, Watanabe, Hideo

“…Molecular characterization of lung squamous cell carcinoma (LUSC), one of the major subtypes of lung cancer, has not sufficiently improved its nonstratified…”
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Three-Staged Stereotactic Radiotherapy Without Whole Brain Irradiation for Large Metastatic Brain Tumors by Higuchi, Yoshinori, M.D, Serizawa, Toru, M.D, Nagano, Osamu, M.D, Matsuda, Shinji, M.D, Ono, Junichi, M.D, Sato, Makoto, R.T, Iwadate, Yasuo, M.D, Saeki, Naokatsu, M.D

“…Purpose To evaluate the efficacy and toxicity of staged stereotactic radiotherapy with a 2-week interfraction interval for unresectable brain metastases more…”
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CD44+ slow‐cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis by Ishimoto, Takatsugu, Oshima, Hiroko, Oshima, Masanobu, Kai, Kazuharu, Torii, Ryota, Masuko, Takashi, Baba, Hideo, Saya, Hideyuki, Nagano, Osamu

“…(Cancer Sci 2010; 101: 673–678) Similar to normal tissue stem cells, cancer stem cells (CSCs) are thought to be quiescent or slow‐cycling and, thereby,…”
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Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407) by Shitara, Kohei, Doi, Toshihiko, Nagano, Osamu, Fukutani, Miki, Hasegawa, Hiromi, Nomura, Shogo, Sato, Akihiro, Kuwata, Takeshi, Asai, Kai, Einaga, Yasuaki, Tsuchihashi, Kenji, Suina, Kentaro, Maeda, Yusuke, Saya, Hideyuki, Ohtsu, Atsushi

“…A previous dose-escalation study of sulfasalazine (SSZ), an inhibitor of cystine-glutamate exchange transporter xc (–), in the variant form of CD44…”
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The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-) by Tsuchihashi, Kenji, Okazaki, Shogo, Ohmura, Mitsuyo, Ishikawa, Miyuki, Sampetrean, Oltea, Onishi, Nobuyuki, Wakimoto, Hiroaki, Yoshikawa, Momoko, Seishima, Ryo, Iwasaki, Yoshimi, Morikawa, Takayuki, Abe, Shinya, Takao, Ayumi, Shimizu, Misato, Masuko, Takashi, Nagane, Motoo, Furnari, Frank B, Akiyama, Tetsu, Suematsu, Makoto, Baba, Eishi, Akashi, Koichi, Saya, Hideyuki, Nagano, Osamu

“…Extracellular free amino acids contribute to the interaction between a tumor and its microenvironment through effects on cellular metabolism and malignant…”
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Comparison of treatment results between 3- and 2-stage Gamma Knife radiosurgery for large brain metastases: a retrospective multi-institutional study by Serizawa, Toru, Higuchi, Yoshinori, Yamamoto, Masaaki, Matsunaga, Shigeo, Nagano, Osamu, Sato, Yasunori, Aoyagi, Kyoko, Yomo, Shoji, Koiso, Takao, Hasegawa, Toshinori, Nakazaki, Kiyoshi, Moriki, Akihito, Kondoh, Takeshi, Nagatomo, Yasushi, Okamoto, Hisayo, Kohda, Yukihiko, Kawai, Hideya, Shidoh, Satoka, Shibazaki, Toru, Onoue, Shinji, Kenai, Hiroyuki, Inoue, Akira, Mori, Hisae

“…In order to obtain better local tumor control for large (i.e., > 3 cm in diameter or > 10 cm3 in volume) brain metastases (BMs), 3-stage and 2-stage Gamma…”
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