Search Results - "Nagamatsu, Go"
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Regulation of primordial follicle formation, dormancy, and activation in mice
Published in Journal of Reproduction and Development (01-01-2021)“…In female reproduction, the oocyte number is limited after birth. To achieve a continuous ovulatory cycle, oocytes are stored in primordial follicles…”
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2
Oocyte aging in comparison to stem cells in mice
Published in Frontiers in aging (11-04-2023)“…To maintain homeostasis, many tissues contain stem cells that can self-renew and differentiate. Based on these functions, stem cells can reconstitute the…”
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3
Reconstitution in vitro of the entire cycle of the mouse female germ line
Published in Nature (London) (10-11-2016)“…Using a protocol that recapitulates both meiosis and oocyte growth in vitro , the authors induce mouse pluripotent stem cells to differentiate into fully…”
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Stem cells, in vitro gametogenesis and male fertility
Published in Reproduction (Cambridge, England) (01-12-2017)“…Reconstitution in culture of biological processes, such as differentiation and organization, is a key challenge in regenerative medicine, and one in which stem…”
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Generation of ovarian follicles from mouse pluripotent stem cells
Published in Science (American Association for the Advancement of Science) (16-07-2021)“…Oocytes mature in a specialized fluid-filled sac, the ovarian follicle, which provides signals needed for meiosis and germ cell growth. Methods have been…”
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Environmental factors for establishment of the dormant state in oocytes
Published in Development, growth & differentiation (01-04-2020)“…Guaranteeing the sustainability of gametogenesis is a fundamental issue for perpetuating the species. In the mammalian ovary, sustainability is accomplished by…”
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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Published in Cell stem cell (03-01-2013)“…Defining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity. Mammalian…”
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Generation of functional oocytes from male mice in vitro
Published in Nature (London) (30-03-2023)“…Sex chromosome disorders severely compromise gametogenesis in both males and females. In oogenesis, the presence of an additional Y chromosome or the loss of…”
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Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis
Published in Development (Cambridge) (15-02-2022)“…In mammals, primordial germ cells (PGCs), the origin of the germ line, are specified from the epiblast at the posterior region where gastrulation…”
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Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice
Published in PLoS genetics (26-03-2020)“…A set of sex chromosomes is required for gametogenesis in both males and females, as represented by sex chromosome disorders causing agametic phenotypes…”
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Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming
Published in Cancer science (01-08-2013)“…Considering the similarities between the transcriptional programming involved in cancer progression and somatic cell reprogramming, we tried to identify drugs…”
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The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage
Published in Development (Cambridge) (01-04-2006)“…Mammalian spermatogenesis is maintained by a continuous supply of differentiating cells from self-renewing stem cells. The stem cell activity resides in a…”
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13
A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming
Published in The Journal of biological chemistry (25-03-2011)“…Germ cells possess the unique ability to acquire totipotency during development in vivo as well as give rise to pluripotent stem cells under the appropriate…”
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Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
Published in eLife (04-04-2024)“…Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells,…”
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Correction: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
Published in eLife (22-10-2024)Get full text
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16
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest
Published in Cell stem cell (07-02-2008)“…Mammalian spermatogenesis is maintained by stem cell capacity within undifferentiated spermatogonial subpopulation. Here, using a combination of surface…”
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Telomerase Reverse Transcriptase Has an Extratelomeric Function in Somatic Cell Reprogramming
Published in The Journal of biological chemistry (30-05-2014)“…Reactivation of the endogenous telomerase reverse transcriptase (TERT) catalytic subunit and telomere elongation occur during the reprogramming of somatic…”
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Conversion of primordial germ cells to pluripotent stem cells: methods for cell tracking and culture conditions
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2013)“…Primordial germ cells (PGCs) are unipotent cells committed to germ lineage: PGCs can only differentiate into gametes in vivo. However, upon fertilization, germ…”
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Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells
Published in Biochemical and biophysical research communications (08-11-2013)“…•Nucleostemin is highly expressed in immature hematopoietic cells including HSCs.•Nucleostemin depletion impairs the self-renewal capacity of…”
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Optimal Ratio of Transcription Factors for Somatic Cell Reprogramming
Published in The Journal of biological chemistry (19-10-2012)“…Somatic cell reprogramming is achieved by four reprogramming transcription factors (RTFs), Oct3/4, Sox2, Klf4, and c-Myc. However, in addition to the induction…”
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