Search Results - "Nagamalleswari, Easa"
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Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria
Published in Proceedings of the National Academy of Sciences - PNAS (15-05-2012)“…Most bacterial genomes harbor restriction–modification systems, encoding a REase and its cognate MTase. On attack by a foreign DNA, the REase recognizes it as…”
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Draft Genome Sequence of Klebsiella pneumoniae OK8, a Multidrug-Resistant Mouse and Human Pathogen
Published in Genome announcements (Washington, DC) (14-09-2017)“…We report here the draft genome sequence of OK8, a multidrug-resistant strain which was isolated in 1976 from a human and is known to be a mouse pathogen…”
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Restriction endonuclease triggered bacterial apoptosis as a mechanism for long time survival
Published in Nucleic acids research (21-08-2017)“…Programmed cell death (PCD) under certain conditions is one of the features of bacterial altruism. Given the bacterial diversity and varied life style,…”
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Divalent Ion-Induced Switch in DNA Cleavage of KpnI Endonuclease Probed through Surface-Enhanced Raman Spectroscopy
Published in The journal of physical chemistry. B (11-03-2021)“…We demonstrate the remarkable ability of surface-enhanced Raman spectroscopy (SERS) to track the allosteric changes in restriction endonuclease KpnI (R.KpnI)…”
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Ca2+ Binding to the ExDxD Motif Regulates the DNA Cleavage Specificity of a Promiscuous Endonuclease
Published in Biochemistry (Easton) (06-11-2012)“…Most of the restriction endonucleases (REases) are dependent on Mg2+ for DNA cleavage, and in general, Ca2+ inhibits their activity. R.KpnI, an HNH active site…”
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Ca(2+) binding to the ExDxD motif regulates the DNA cleavage specificity of a promiscuous endonuclease
Published in Biochemistry (Easton) (06-11-2012)“…Most of the restriction endonucleases (REases) are dependent on Mg(2+) for DNA cleavage, and in general, Ca(2+) inhibits their activity. R.KpnI, an HNH active…”
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Ca super(2+) Binding to the ExDxD Motif Regulates the DNA Cleavage Specificity of a Promiscuous Endonuclease
Published in Biochemistry (Easton) (06-11-2012)“…Most of the restriction endonucleases (REases) are dependent on Mg super(2+) for DNA cleavage, and in general, Ca super(2+) inhibits their activity. R.KpnI, an…”
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8
Ca 2+ Binding to the ExDxD Motif Regulates the DNA Cleavage Specificity of a Promiscuous Endonuclease
Published in Biochemistry (Easton) (06-11-2012)Get full text
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9
Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria
Published in Proceedings of the National Academy of Sciences - PNAS (15-05-2012)Get full text
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10
SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome
Published in Science advances (02-08-2023)“…Ubiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2, and E3 enzymes with E3s providing substrate specificity. Mass spectrometry-based…”
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Increasing cleavage specificity and activity of restriction endonuclease KpnI
Published in Nucleic acids research (01-11-2013)“…Restriction enzyme KpnI is a HNH superfamily endonuclease requiring divalent metal ions for DNA cleavage but not for binding. The active site of KpnI can…”
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