Search Results - "Nagai, Toshio"

Systemic Transfusion of Human Umbilical Cord-Derived Mesenchymal Stromal Cells　― Toward Less Invasive and More Effective Cell Therapy for Severe Peripheral Arterial Disease by Nagai, Toshio

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Pericardial Grafting of Cardiac Progenitor Cells in Self-Assembling Peptide Scaffold Improves Cardiac Function After Myocardial Infarction by Kanda, Masato, Nagai, Toshio, Kondo, Naomichi, Matsuura, Katsuhisa, Akazawa, Hiroshi, Komuro, Issei, Kobayashi, Yoshio

“…Many studies have explored cardiac progenitor cell (CPC) therapy for heart disease. However, optimal scaffolds are needed to ensure the engraftment of…”
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Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice by Matsuura, Katsuhisa, Honda, Atsushi, Nagai, Toshio, Fukushima, Noritoshi, Iwanaga, Koji, Tokunaga, Masakuni, Shimizu, Tatsuya, Okano, Teruo, Kasanuki, Hiroshi, Hagiwara, Nobuhisa, Komuro, Issei

“…Cardiac progenitor cells are a potential source of cell therapy for heart failure. Although recent studies have shown that transplantation of cardiac…”
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Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function by Nagai, Toshio, Komuro, Issei

“…Despite significant advances in pharmacological and clinical treatment, heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Many…”
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Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway by Kunieda, Takeshige, Minamino, Tohru, Nishi, Jun-Ichiro, Tateno, Kaoru, Oyama, Tomomi, Katsuno, Taro, Miyauchi, Hideyuki, Orimo, Masayuki, Okada, Sho, Takamura, Masayuki, Nagai, Toshio, Kaneko, Shuichi, Komuro, Issei

“…Angiotensin II (Ang II) has been reported to contribute to the pathogenesis of various human diseases including atherosclerosis, and inhibition of Ang II…”
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Adult Cardiac Sca-1-positive Cells Differentiate into Beating Cardiomyocytes by Matsuura, Katsuhisa, Nagai, Toshio, Nishigaki, Nobuhiro, Oyama, Tomomi, Nishi, Junichiro, Wada, Hiroshi, Sano, Masanori, Toko, Haruhiro, Akazawa, Hiroshi, Sato, Toshiaki, Nakaya, Haruaki, Kasanuki, Hiroshi, Komuro, Issei

“…Although somatic stem cells have been reported to exist in various adult organs, there have been few reports concerning stem cells in the heart. We here…”
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Neonatal Rat Heart Response to Pressure Overload: Another Difference Between the Adult and Neonatal Mammalian Heart by Kanda, Masato, Nagai, Toshio

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Regeneration of the Cardiac Conduction System by Adipose Tissue-Derived Stem Cells by Takahashi, Toshinao, Nagai, Toshio, Kanda, Masato, Liu, Mei-Lan, Kondo, Naomichi, Naito, Atsuhiko T, Ogura, Takehiko, Nakaya, Haruaki, Lee, Jong-Kook, Komuro, Issei, Kobayashi, Yoshio

“…Background:Adipose tissue is one of the sources of mesenchymal stem cells, which have the potential to differentiate into various types of cells, including…”
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II by Komuro, Issei, Zou, Yunzeng, Akazawa, Hiroshi, Qin, Yingjie, Sano, Masanori, Takano, Hiroyuki, Minamino, Tohru, Makita, Noriko, Iwanaga, Koji, Zhu, Weidong, Kudoh, Sumiyo, Toko, Haruhiro, Tamura, Koichi, Kihara, Minoru, Nagai, Toshio, Fukamizu, Akiyoshi, Umemura, Satoshi, Iiri, Taroh, Fujita, Toshiro

“…The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by…”
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Mitochondrial Aldehyde Dehydrogenase 2 Plays Protective Roles in Heart Failure After Myocardial Infarction via Suppression of the Cytosolic JNK/p53 Pathway in Mice by Sun, Aijun, Zou, Yunzeng, Wang, Ping, Xu, Danling, Gong, Hui, Wang, Shijun, Qin, Yingjie, Zhang, Peng, Chen, Yunqin, Harada, Mutsuo, Isse, Toyoshi, Kawamoto, Toshihiro, Fan, Huizhi, Yang, Pengyuan, Akazawa, Hiroshi, Nagai, Toshio, Takano, Hiroyuki, Ping, Peipei, Komuro, Issei, Ge, Junbo

“…Background Increasing evidence suggests a critical role for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in protection against cardiac injuries; however, the…”
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Cardiac side population cells and Sca-1-positive cells by Nagai, Toshio, Matsuura, Katsuhisa, Komuro, Issei

“…Since the resident cardiac stem/progenitor cells were discovered, their ability to maintain the architecture and functional integrity of adult heart has been…”
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Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction by Kanda, Masato, Nagai, Toshio, Takahashi, Toshinao, Liu, Mei Lan, Kondou, Naomichi, Naito, Atsuhiko T, Akazawa, Hiroshi, Sashida, Goro, Iwama, Atsushi, Komuro, Issei, Kobayashi, Yoshio

“…Cardiac stem cells or precursor cells regenerate cardiomyocytes; however, the mechanism underlying this effect remains unclear. We generated CreLacZ mice in…”
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Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction by Tokunaga, Masakuni, Liu, Mei-Lan, Nagai, Toshio, Iwanaga, Koji, Matsuura, Katsuhisa, Takahashi, Toshinao, Kanda, Masato, Kondo, Naomichi, Wang, Pin, Naito, Atsuhiko T, Komuro, Issei

“…Abstract Implantation of various types of cells into the heart has been reported to be effective for heart failure, however, it is unknown what kinds of cells…”
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Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells by Ozasa, Yukako, Akazawa, Hiroshi, Qin, Yingjie, Tateno, Kaoru, Ito, Kaoru, Kudo-Sakamoto, Yoko, Yano, Masamichi, Yabumoto, Chizuru, Naito, Atsuhiko T, Oka, Toru, Lee, Jong-Kook, Minamino, Tohru, Nagai, Toshio, Kobayashi, Yoshio, Komuro, Issei

“…Notch signaling is involved in an intercellular communication mechanism that is essential for coordinated cell fate determination and tissue morphogenesis. The…”
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Critical Roles of Muscle-Secreted Angiogenic Factors in Therapeutic Neovascularization by Tateno, Kaoru, Minamino, Tohru, Toko, Haruhiro, Akazawa, Hiroshi, Shimizu, Naomi, Takeda, Shinichi, Kunieda, Takeshige, Miyauchi, Hideyuki, Oyama, Tomomi, Matsuura, Katsuhisa, Nishi, Jun-ichiro, Kobayashi, Yoshio, Nagai, Toshio, Kuwabara, Yoichi, Iwakura, Yoichiro, Nomura, Fumio, Saito, Yasushi, Komuro, Issei

“…The discovery of bone marrow–derived endothelial progenitors in the peripheral blood has promoted intensive studies on the potential of cell therapy for…”
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Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases by Takano, Hiroyuki, Zou, Yunzeng, Hasegawa, Hiroshi, Akazawa, Hiroshi, Nagai, Toshio, Komuro, Issei

“…Reactive oxygen species (ROS) are proposed to contribute to the deterioration of cardiac function in patients with heart diseases. It has been reported that…”
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Effects of Antiarrhythmic Drugs on the Hyperpolarization-Activated Cyclic Nucleotide–Gated Channel Current by Tamura, Atsushi, Ogura, Takehiko, Uemura, Hiroko, Reien, Yoshie, Kishimoto, Takashi, Nagai, Toshio, Komuro, Issei, Miyazaki, Masaru, Nakaya, Haruaki

“…After the report of the Cardiac Arrhythmia Suppression Trial, a tabular framework of the Sicilian Gambit has been proposed to display actions of antiarrhythmic…”
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Systemic Transfusion of Human Umbilical Cord-Derived Mesenchymal Stromal Cells　― Toward Less Invasive and More Effective Cell Therapy for Severe Peripheral Arterial Disease by Nagai, Toshio

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Phosphatidylinositol 3-Kinase–Akt Pathway Plays a Critical Role in Early Cardiomyogenesis by Regulating Canonical Wnt Signaling by Naito, Atsuhiko T, Akazawa, Hiroshi, Takano, Hiroyuki, Minamino, Tohru, Nagai, Toshio, Aburatani, Hiroyuki, Komuro, Issei

“…We have recently reported that activation of phosphatidylinositol 3-kinase (PI3K) plays a critical role in the early stage of cardiomyocyte differentiation of…”
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Anti‐Inflammatory Peptides From Cardiac Progenitors Ameliorate Dysfunction After Myocardial Infarction by Liu, Mei‐Lan, Nagai, Toshio, Tokunaga, Masakuni, Iwanaga, Koji, Matsuura, Katsuhisa, Takahashi, Toshinao, Kanda, Masato, Kondo, Naomichi, Naito, Atsuhiko T., Komuro, Issei, Kobayashi, Yoshio

“…Background Cardiac cell therapy has been proposed as one of the new strategies against myocardial infarction. Although several reports showed improvement of…”
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