Search Results - "Nagai, Junya"

Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity by Nagai, Junya, Takano, Mikihisa

“…Aminoglycosides such as gentamicin and amikacin are the most commonly used antibiotics worldwide in the treatment of Gram-negative bacterial infections…”
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Pharmacokinetic–pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats by Miyazaki, Makoto, Hayata, Mariko, Samukawa, Noriaki, Iwanaga, Kazunori, Nagai, Junya

“…The relationship between the plasma insulin (INS) concentration–time course and plasma glucose concentration–time course during and after pulsatile INS…”
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Endocytic Uptake of FITC-albumin by Human Alveolar Epithelial Cell Line A549 by Yumoto, Ryoko, Suzuka, Sayuri, Oda, Keisuke, Nagai, Junya, Takano, Mikihisa

“…The uptake mechanism of FITC-labeled albumin (FITC-albumin) was examined in human alveolar epithelial cell line A549. FITC-albumin uptake by A549 cells was…”
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Effects of endocytosis inhibitors on internalization of human IgG by Caco-2 human intestinal epithelial cells by Sato, Koya, Nagai, Junya, Mitsui, Naoko, Ryoko Yumoto, Takano, Mikihisa

“…The purpose of this study was to characterize the internalization mechanism of human IgG into the epithelial cells of human small intestine, employing human…”
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Fatty acids bound to albumin induce prostaglandin E2 production in human renal proximal tubular epithelial cell line HK-2 by Nakatsuji, Minori, Urakami-Takebayashi, Yumiko, Miyadokoro, Sae, Ikeda, Toyoaki, Takehara, Ikki, Sun, Hongxin, Motohashi, Hideyuki, Ohno, Yoshio, Nagai, Junya

“…Fatty acids bound to albumin have been reported to be involved in various responses in renal proximal tubular cells following albumin overload, leading to…”
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Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2 by Urakami-Takebayashi, Yumiko, Kuroda, Yukimi, Murata, Tadashi, Miyazaki, Makoto, Nagai, Junya

“…We previously reported that fatty acid-bearing albumin but not fatty acid-depleted albumin induces hypoxia-inducible factor-1 (HIF-1) activation in human renal…”
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Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2 by Nishihashi, Katsuki, Kawashima, Kei, Nomura, Takami, Urakami-Takebayashi, Yumiko, Miyazaki, Makoto, Takano, Mikihisa, Nagai, Junya

“…The human breast cancer resistance protein (BCRP/ABCG2), a member of the ATP-binding cassette transporter family, is a drug transporter restricting absorption…”
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Characterization of Protamine Uptake by Opossum Kidney Epithelial Cells by Nagai, Junya, Komeda, Takuji, Katagiri, Yuki, Yumoto, Ryoko, Takano, Mikihisa

“…Protamine, a mixture of polypeptides that is rich in arginine, has been used clinically as an antidote to heparin overdoses and a complexing agent in a…”
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Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice by Jin, Congyun, Yonezawa, Atsushi, Yoshimatsu, Hiroki, Imai, Satoshi, Koyanagi, Madoka, Yamanishi, Kaori, Nakagawa, Shunsaku, Itohara, Kotaro, Omura, Tomohiro, Nakagawa, Takayuki, Nagai, Junya, Matsubara, Kazuo

“…Riboflavin transporter 3 (RFVT3), encoded by the SLC52A3 gene, is important for riboflavin homeostasis in the small intestine, kidney, and placenta. Our…”
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Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs by Nagai, Junya, Takano, Mikihisa

“…Nephrotoxicity limits the clinical use of some antibiotics, cancer chemotherapeutics and diagnostic agents. Some nephrotoxic drugs are highly accumulated in…”
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Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents by VAARA, Martti, FOX, John, LOIDL, Günther, SIIKANEN, Osmo, APAJALAHTI, Juha, HANSEN, Frank, FRIMODT-MØLLER, Niels, NAGAI, Junva, TAKANO, Mikihisa, VAARA, Timo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effect of protamine on the accumulation of gentamicin in opossum kidney epithelial cells by Nagai, Junya, Komeda, Takuji, Yumoto, Ryoko, Takano, Mikihisa

“…Objectives The purpose of this study was to examine whether or not protamine, an arginine‐rich basic protein mixture, inhibits the accumulation of gentamicin,…”
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Comparison of Albumin Uptake in Rat Alveolar Type II and Type I-like Epithelial Cells in Primary Culture by Ikehata, Mika, Yumoto, Ryoko, Nakamura, Kosuke, Nagai, Junya, Takano, Mikihisa

“…Purpose To elucidate and compare the activity and mechanism of albumin uptake in primary cultured alveolar type II and type I-like epithelial cells. Materials…”
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Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells by Takano, Mikihisa, Horiuchi, Taishi, Sasaki, Yoshihiro, Kato, Yuki, Nagai, Junya, Yumoto, Ryoko

“…The purpose of this study was to clarify the expression and function of peptide transporter 2 (PEPT2) in primary cultured alveolar type II epithelial cells and…”
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Megalin/Cubilin-mediated Uptake of FITC-labeled IgG by OK Kidney Epithelial Cells by Nagai, Junya, Sato, Koya, Yumoto, Ryoko, Takano, Mikihisa

“…In this paper, we characterize the uptake mechanism of fluorescein isothiocyanate-labeled human immunoglobulin G (FITC-hIgG) in opossum kidney (OK) epithelial…”
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Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN by Yumoto, Ryoko, Nishikawa, Hiromi, Okamoto, Miho, Katayama, Hirokazu, Nagai, Junya, Takano, Mikihisa

“…We examined mechanisms of FITC-albumin uptake by alveolar type II epithelial cells using cultured RLE-6TN cells. Alkaline phosphatase activity and the…”
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Accumulation and photodynamic activity of chlorin e6 in cisplatin-resistant human lung cancer cells by Horibe, Sayo, Nagai, Junya, Yumoto, Ryoko, Tawa, Riichi, Takano, Mikihisa

“…Cisplatin or cis-diamminedichloroplatinum (II) (CDDP) is one of the most potent anticancer drugs, but the emergence of acquired resistance to CDDP is a major…”
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Paclitaxel-resistance Conferred by Altered Expression of Efflux and Influx Transporters for Paclitaxel in the Human Hepatoma Cell Line, HepG2 by Takano, Mikihisa, Otani, Yoshifumi, Tanda, Minori, Kawami, Masashi, Nagai, Junya, Yumoto, Ryoko

“…Paclitaxel-resistant HepG2 (PR-HepG2) cells were established by long-term exposure of HepG2 cells to paclitaxel and expression and function of efflux…”
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Mechanism of Insulin Uptake in Rat Alveolar Type II and Type I-Like Epithelial Cells by Ikehata, Mika, Yumoto, Ryoko, Kato, Yuki, Nagai, Junya, Takano, Mikihisa

“…The mechanism underlying the handling of protein and peptide drugs such as insulin in alveolar epithelial cells is still unclear. We therefore examined…”
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Function and Expression of ATP-Binding Cassette Transporters in Cultured Human Y79 Retinoblastoma Cells by Ishikawa, Yuka, Nagai, Junya, Okada, Yumi, Sato, Koya, Yumoto, Ryoko, Takano, Mikihisa

“…The aim of this study was to reveal the expression and function of P-glycoprotein and multidrug resistance-associated proteins (MRP), members of the…”
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