Search Results - "Nagahashi, Noboru"

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate) by Abe, Hiroyuki, Kikuchi, Shinichi, Hayakawa, Kazuhide, Iida, Tetsuya, Nagahashi, Noboru, Maeda, Katsuya, Sakamoto, Johei, Matsumoto, Noriaki, Miura, Tomoya, Matsumura, Koji, Seki, Noriyoshi, Inaba, Takashi, Kawasaki, Hisashi, Yamaguchi, Takayuki, Kakefuda, Reina, Nanayama, Toyomichi, Kurachi, Hironori, Hori, Yoshikazu, Yoshida, Takayuki, Kakegawa, Junya, Watanabe, Yoshihiro, Gilmartin, Aidan G, Richter, Mark C, Moss, Katherine G, Laquerre, Sylvie G

“…Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) represents a promising strategy for the discovery of a new…”
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Correction to "Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors" by Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito

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Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein–Protein Interaction Inhibitors by Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito

“…In research focused on protein–protein interaction (PPI) inhibitors, the optimization process to achieve both high inhibitory activity and favorable…”
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Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor by Otake, Kazuki, Ubukata, Minoru, Nagahashi, Noboru, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito

“…Oxidative stress is one of the causes of progression of chronic kidney disease (CKD). Activation of the antioxidant protein regulator Nrf2 by inhibition of the…”
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Synthetic research on cyclitols using C6-chiron, 6-(benzyloxy)-3-cyclohexen-1-ol: A concise and highly diastereoselective synthesis of (−)-gala-quercitol by Maezaki, Naoyoshi, Nagahashi, Noboru, Yoshigami, Ryoko, Iwata, Chuzo, Tanaka, Tetsuaki

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C2-Symmetric Bis-sulfoxide:  A Novel Chiral Auxiliary for Asymmetric Desymmetrization of Cyclic meso-1,2-Diols by MAEZAKI, Naoyoshi, SAKAMOTO, Atsunobu, NAGAHASHI, Noboru, SOEJIMA, Motohiro, LI, Ying-Xia, IMAMURA, Tsuneaki, KOJIMA, Naoto, OHISHI, Hirofumi, SAKAGUCHI, Ken-ichi, IWATA, Chuzo, TANAKA, Tetsuaki

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Synthetic research on cyclitols using C 6-chiron, 6-(benzyloxy)-3-cyclohexen-1-ol: A concise and highly diastereoselective synthesis of (−)- gala-quercitol by Maezaki, Naoyoshi, Nagahashi, Noboru, Yoshigami, Ryoko, Iwata, Chuzo, Tanaka, Tetsuaki

“…Transformation of a C 6-chiron, 6-(benzyloxy)-3-cyclohexen-1-ol into polyoxygenated cyclohexanes involving a stereodivergent epoxide rearrangement was…”
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C 2-Symmetric Bis-sulfoxide:  A Novel Chiral Auxiliary for Asymmetric Desymmetrization of Cyclic m eso-1,2-Diols by Maezaki, Naoyoshi, Sakamoto, Atsunobu, Nagahashi, Noboru, Soejima, Motohiro, Li, Ying-Xia, Imamura, Tsuneaki, Kojima, Naoto, Ohishi, Hirofumi, Sakaguchi, Ken-ichi, Iwata, Chuzo, Tanaka, Tetsuaki

“…A new heterocyclic compound, C 2-symmetric bis-sulfoxide 1, has been found to be an efficient chiral auxiliary for asymmetric desymmetrization of cyclic…”
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