Search Results - "Nagafuku, N."
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Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration
Published in Toxicology and applied pharmacology (01-10-2023)“…Methodical screening of safe and efficient drug candidate compounds is crucial for drug development. A high-throughput and accurate compound evaluation method…”
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Analysis of signal components < 500 Hz in brain organoids coupled to microelectrode arrays: A reliable test-bed for preclinical seizure liability assessment of drugs and screening of antiepileptic drugs
Published in Biochemistry and biophysics reports (01-12-2021)“…Brain organoids with three-dimensional structure and tissue-like function are highly demanded for brain disease research and drug evaluation. However, to our…”
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P21-20: MEA assessment for neurotoxicity of pesticide-related compounds in human iPS cell-derived neurons
Published in Toxicology letters (01-09-2023)Get full text
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