Search Results - "Nag, Partha"

A substrate-driven allosteric switch that enhances PDI catalytic activity by Bekendam, Roelof H., Bendapudi, Pavan K., Lin, Lin, Nag, Partha P., Pu, Jun, Kennedy, Daniel R., Feldenzer, Alexandra, Chiu, Joyce, Cook, Kristina M., Furie, Bruce, Huang, Mingdong, Hogg, Philip J., Flaumenhaft, Robert

“…Protein disulfide isomerase (PDI) is an oxidoreductase essential for folding proteins in the endoplasmic reticulum. The domain structure of PDI is a – b – b′ –…”
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A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase by Wellington, Samantha, Nag, Partha P, Michalska, Karolina, Johnston, Stephen E, Jedrzejczak, Robert P, Kaushik, Virendar K, Clatworthy, Anne E, Siddiqi, Noman, McCarren, Patrick, Bajrami, Besnik, Maltseva, Natalia I, Combs, Senya, Fisher, Stewart L, Joachimiak, Andrzej, Schreiber, Stuart L, Hung, Deborah T

“…High-throughput screening identifies an inhibitor of the interaction between α- and β-subunits of the Mycobacterium tuberculosis (Mtb) tryptophan synthase,…”
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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes by Sharabi, Kfir, Lin, Hua, Tavares, Clint D.J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere

“…Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP)…”
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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase by Michalska, Karolina, Chang, Changsoo, Maltseva, Natalia I., Jedrzejczak, Robert, Robertson, Gregory T., Gusovsky, Fabian, McCarren, Patrick, Schreiber, Stuart L., Nag, Partha P., Joachimiak, Andrzej

“…Global dispersion of multidrug resistant bacteria is very common and evolution of antibiotic‐resistance is occurring at an alarming rate, presenting a…”
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Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis by Rossmann, Marlies P, Hoi, Karen, Chan, Victoria, Abraham, Brian J, Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R, Hagedorn, Elliott J, Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P, Sullivan, Lucas B, Warren, Curtis R, Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A, Schreiber, Stuart L, Young, Richard A, Meissner, Alexander, Haigis, Marcia C, Hekimi, Siegfried, Carr, Steven A, Zon, Leonard I

“…Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been…”
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Stereocontrolled Synthesis of the Tricyclic ABC Ring System of Daphnicyclidin A by Williams, David R, Mondal, Prolay K, Bawel, Seth A, Nag, Partha P

“…An enantiocontrolled synthesis pathway has been developed to provide formation of tricyclic amine 7, representing the ABC ring system of the complex alkaloid…”
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Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model by Grant, Sarah Schmidt, Kawate, Tomohiko, Nag, Partha P, Silvis, Melanie R, Gordon, Katherine, Stanley, Sarah A, Kazyanskaya, Edward, Nietupski, Raymond, Golas, Aaron, Fitzgerald, Michael, Cho, Sanghyun, Franzblau, Scott G, Hung, Deborah T

“…During Mycobacterium tuberculosis infection, a population of bacteria is thought to exist in a nonreplicating state, refractory to antibiotics, which may…”
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Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation by Neale, Ilona, Reddy, Clark, Tan, Zher Yin, Li, Bihua, Nag, Partha P, Park, Joshua, Park, Jihye, Carey, Kimberly L, Graham, Daniel B, Xavier, Ramnik J

“…The proton-sensing heterotrimeric guanine nucleotide-binding protein-coupled receptor GPR65 is expressed in immune cells and regulates tissue homeostasis in…”
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Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects by Wagner, Florence F, Bishop, Joshua A, Gale, Jennifer P, Shi, Xi, Walk, Michelle, Ketterman, Joshua, Patnaik, Debasis, Barker, Doug, Walpita, Deepika, Campbell, Arthur J, Nguyen, Shannon, Lewis, Michael, Ross, Linda, Weïwer, Michel, An, W. Frank, Germain, Andrew R, Nag, Partha P, Metkar, Shailesh, Kaya, Taner, Dandapani, Sivaraman, Olson, David E, Barbe, Anne-Laure, Lazzaro, Fanny, Sacher, Joshua R, Cheah, Jaime H, Fei, David, Perez, Jose, Munoz, Benito, Palmer, Michelle, Stegmaier, Kimberly, Schreiber, Stuart L, Scolnick, Edward, Zhang, Yan-Ling, Haggarty, Stephen J, Holson, Edward B, Pan, Jen Q

“…The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase…”
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Conservation of the structure and function of bacterial tryptophan synthases by Michalska, Karolina, Gale, Jennifer, Joachimiak, Grazyna, Chang, Changsoo, Hatzos-Skintges, Catherine, Nocek, Boguslaw, Johnston, Stephen E, Bigelow, Lance, Bajrami, Besnik, Jedrzejczak, Robert P, Wellington, Samantha, Hung, Deborah T, Nag, Partha P, Fisher, Stewart L, Endres, Michael, Joachimiak, Andrzej

“…Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from and serve as model systems. Tryptophan synthase…”
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Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake by Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Yu, Miao, Youngsaye, Willmen, Nag, Partha P., Bennion, Melissa, Penman, Marsha, Nieland, Thomas J.F., Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty

“…[Display omitted] A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was…”
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Identification of a selective small molecule inhibitor of breast cancer stem cells by Germain, Andrew R., Carmody, Leigh C., Morgan, Barbara, Fernandez, Cristina, Forbeck, Erin, Lewis, Timothy A., Nag, Partha P., Ting, Amal, VerPlank, Lynn, Feng, Yuxiong, Perez, Jose R., Dandapani, Sivaraman, Palmer, Michelle, Lander, Eric S., Gupta, Piyush B., Schreiber, Stuart L., Munoz, Benito

“…A high-throughput screen (HTS) with the National Institute of Health–Molecular Libraries Small Molecule Repository (NIH–MLSMR) compound collection identified a…”
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Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells by Germain, Andrew R., Carmody, Leigh C., Nag, Partha P., Morgan, Barbara, VerPlank, Lynn, Fernandez, Cristina, Donckele, Etienne, Feng, Yuxiong, Perez, Jose R., Dandapani, Sivaraman, Palmer, Michelle, Lander, Eric S., Gupta, Piyush B., Schreiber, Stuart L., Munoz, Benito

“…A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from…”
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Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells by Carmody, Leigh C, Germain, Andrew R, VerPlank, Lynn, Nag, Partha P, Muñoz, Benito, Perez, Jose R, Palmer, Michelle A J

“…Cancer stem cells (CSCs) are resistant to standard cancer treatments and are likely responsible for cancer recurrence, but few therapies target this…”
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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies by Dockendorff, Chris, Nagiec, Marek M, Weïwer, Michel, Buhrlage, Sara, Ting, Amal, Nag, Partha P, Germain, Andrew, Kim, Han-Je, Youngsaye, Willmen, Scherer, Christina, Bennion, Melissa, Xue, Linlong, Stanton, Benjamin Z, Lewis, Timothy A, MacPherson, Lawrence, Palmer, Michelle, Foley, Michael A, Perez, José R, Schreiber, Stuart L

“…Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle…”
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Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport by Dockendorff, Chris, Faloon, Patrick W, Yu, Miao, Youngsaye, Willmen, Penman, Marsha, Nieland, Thomas J. F, Nag, Partha P, Lewis, Timothy A, Pu, Jun, Bennion, Melissa, Negri, Joseph, Paterson, Conor, Lam, Garrett, Dandapani, Sivaraman, Perez, José R, Munoz, Benito, Palmer, Michelle A, Schreiber, Stuart L, Krieger, Monty

“…A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a…”
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ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans by Youngsaye, Willmen, Hartland, Cathy L, Morgan, Barbara J, Ting, Amal, Nag, Partha P, Vincent, Benjamin, Mosher, Carrie A, Bittker, Joshua A, Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L, Munoz, Benito

“…The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to…”
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Studies of the Generation and Pericyclic Behavior of Cyclic Pentadienyl Carbanions. Alkylation Reactions as an Efficient Route to Functionalized cis-Bicyclo[3.3.0]octenes by Williams, David R, Reeves, Jonathan T, Nag, Partha P, Pitcock, William H, Baik, Mu-Hyun

“…Carbolithiation has been studied with alkyllithium reagents in a series of six- through nine-membered 3-methylene-1,4-cycloalkadienes, efficiently producing…”
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Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis by Park, Sae Woong, Casalena, Dominick E., Wilson, Daniel J., Dai, Ran, Nag, Partha P., Liu, Feng, Boyce, Jim P., Bittker, Joshua A., Schreiber, Stuart L., Finzel, Barry C., Schnappinger, Dirk, Aldrich, Courtney C.

“…Biotin biosynthesis is essential for survival and persistence of Mycobacterium tuberculosis (Mtb) in vivo. The aminotransferase BioA, which catalyzes the…”
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Samarium Barbier Reactions of α-Iodomethyloxazoles and Thiazoles with Aliphatic Aldehydes by Williams, David R, Berliner, Martin A, Stroup, Bryan W, Nag, Partha P, Clark, Michael P

“…The reductive coupling of substituted α-iodomethyloxazoles and thiazoles with aliphatic aldehydes under Barbier conditions provides an effective method for the…”
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