Search Results - "Nag, Alo"
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FoxM1: Repurposing an oncogene as a biomarker
Published in Seminars in cancer biology (01-10-2018)“…The past few decades have witnessed a tremendous progress in understanding the biology of cancer, which has led to more comprehensive approaches for global…”
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Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19
Published in Open biology (01-06-2021)“…The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the…”
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CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
Published in Open biology (12-02-2014)“…The ability of cullin 4A (CUL4A), a scaffold protein, to recruit a repertoire of substrate adaptors allows it to assemble into distinct E3 ligase complexes to…”
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Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity
Published in Scientific reports (18-01-2022)“…Malaria has endured as a global epidemic since ages and its eradication poses an immense challenge due to the complex life cycle of the causative pathogen and…”
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A Comprehensive Review on miR-200c, A Promising Cancer Biomarker with Therapeutic Potential
Published in Current drug targets (01-11-2015)“…MicroRNAs (miRNAs) are small single stranded non coding RNA molecules (~22 nucleotides) which impede protein production by directly interacting with…”
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Peroxisome Proliferator Activated Receptor Gamma Sensitizes Non-small Cell Lung Carcinoma to Gamma Irradiation Induced Apoptosis
Published in Frontiers in genetics (13-06-2019)“…The nuclear receptors known as peroxisome proliferator activated receptor gamma (PPARG) are lipid-activated transcription factors that have emerged as key…”
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Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
Published in Frontiers in oncology (24-11-2021)“…The aberrant up-regulation of the oncogenic transcription factor Forkhead box M1 (FoxM1) is associated with tumor development, progression and metastasis in a…”
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Colocynth Extracts Prevent Epithelial to Mesenchymal Transition and Stemness of Breast Cancer Cells
Published in Frontiers in pharmacology (05-09-2017)“…Modern treatment strategies provide better overall survival in cancer patients, primarily by controlling tumor growth. However, off-target and systemic…”
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Cellular iron homeostasis and therapeutic implications of iron chelators in cancer
Published in Current pharmaceutical biotechnology (01-01-2014)“…Iron metabolism and homeostasis are imperative for the maintenance of normal physiological activities due to the element's critical involvement in a wide…”
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Tale of a multifaceted co-activator, hADA3: from embryogenesis to cancer and beyond
Published in Open biology (01-09-2016)“…Human ADA3, the evolutionarily conserved transcriptional co-activator, remains the unified part of multiple cellular functions, including regulation of nuclear…”
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Cullin 4A Associates with the UV-damaged DNA-binding Protein DDB
Published in The Journal of biological chemistry (10-12-1999)“…The damaged DNA-binding protein (DDB) is believed to be involved in DNA repair, and it has been linked to the repair deficiency disease xeroderma pigmentosum…”
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Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc
Published in The Journal of biological chemistry (27-08-2004)“…The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and activate the functions of p53. Here we provide evidence for an…”
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The Xeroderma Pigmentosum Group E Gene Product DDB2 Is a Specific Target of Cullin 4A in Mammalian Cells
Published in Molecular and Cellular Biology (01-10-2001)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An Essential Role of Human Ada3 in p53 Acetylation
Published in The Journal of biological chemistry (23-03-2007)“…The p53 tumor suppressor protein functions as a critical component of genotoxic stress response by regulating the expression of effector gene products that…”
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Differential Regulation of E2F1, DP1, and the E2F1/DP1 Complex by ARF
Published in Molecular and Cellular Biology (01-12-2002)“…ERRATUM ( vol. 23 , p. 3374 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Effects of Depletion of CREB-binding Protein on c-Myc Regulation and Cell Cycle G1-S Transition
Published in The Journal of biological chemistry (07-01-2005)“…We recently reported that the transcriptional coactivator and histone acetyltransferase p300 plays an important role in the G1 phase of the cell cycle by…”
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The pint- sized powerhouse: Illuminating the mighty role of the gut microbiome in improving the outcome of anti- cancer therapy
Published in Seminars in cancer biology (01-05-2021)“…Cancer persists as a major health catastrophe and a leading cause of widespread mortality across every nation. Research of several decades has increased our…”
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Significance of human microbiome in breast cancer: Tale of an invisible and an invincible
Published in Seminars in cancer biology (01-05-2021)“…The human microbiome is a mysterious treasure of the body playing endless important roles in the well-being of the host metabolism, digestion, and immunity. On…”
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Human ADA3 Binds to Estrogen Receptor (ER) and Functions As a Coactivator for ER-mediated Transactivation
Published in The Journal of biological chemistry (24-12-2004)“…We have recently identified the hADA3 protein, the human homologue of yeast transcriptional coactivator yADA3, as a novel HPV16 E6 target. Using ectopic…”
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