Search Results - "Nafria, Monica"

Standing at odds: mutated RAS and hematopoietic stem cells by Nafria, Monica, Bonifer, Constanze

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Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells by Nafria, Monica, Keane, Peter, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Bonifer, Constanze

“…Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, chromatin, and/or signaling…”
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Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming by Ward, Carl, Volpe, Giacomo, Cauchy, Pierre, Ptasinska, Anetta, Almaghrabi, Ruba, Blakemore, Daniel, Nafria, Monica, Kestner, Doris, Frampton, Jon, Murphy, George, Buganim, Yosef, Kaji, Keisuke, García, Paloma

“…During somatic reprogramming, Yamanaka’s pioneer factors regulate a complex sequence of molecular events leading to the activation of a network of pluripotency…”
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Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells by Nafria, Monica, Bonifer, Constanze, Stanley, Edouard Guy, Ng, Elizabeth Siewsun, Elefanty, Andrew George

“…This protocol offers a detailed procedure for the in vitro differentiation of human pluripotent stem cells (hPSCs) to multipotent hematopoietic progenitors…”
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RUNX1-ETO RAPIDLY REPROGRAMS THE EPIGENETIC LANDSCAPE IN HUMAN EMBRYONIC DEFINITIVE HAEMATOPOIETIC PROGENITORS by Nafria, Monica, Keane, Peter, Ng, Elisabeth, Garcia, Paloma, Stanley, Ed, Elefanty, Andrew, Bonifer, Constanze

“…Acute Myeloid Leukaemia results from the successive acquisition of multiple genetic aberrations. Therefore, the sole study of patient samples, which represent…”
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PLCG1 is required for AML1-ETO leukemia stem cell self-renewal by Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A., Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei, Heidenreich, Olaf, Mann, Matthias, Lane, Steven W., Bullinger, Lars, Ori, Alessandro, von Eyss, Björn, Bonifer, Constanze, Heidel, Florian H.

“…In an effort to identify novel drugs targeting fusion-oncogene–induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In…”
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Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal by Schnoeder, Tina M., Schwarzer, Adrian, Perner, Florian, Kirkpatrick, Joanna, Dolnik, Anna, Döhner, Konstanze, Arreba-Tutusaus, Patricia, Assi, Salam A., Bruedigam, Claudia, Kathner, Carolin, Eifert, Theresa, Buschbeck, Marcus, Nafria I Fedi, Monica, Ptasinska, Anetta, Elefanty, Andrew, Ng, Elizabeth, Bierhoff, Holger, Gras, Florian, Matziolis, Georg, Fischer, Klaus-Dieter, Heidenreich, Olaf, Lane, Steven W., Bullinger, Lars, von Eyss, Björn, Ori, Alessandro, Bonifer, Constanze, Heidel, Florian H.

“…Chromosomal translocations found in acute myeloid leukemia (AML) can generate oncogenic fusions with aberrant epigenetic and transcriptional functions…”
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Modelling the Earliest Events of t(8;21) Acute Myeloid Leukaemia in Human Embryonic Stem Cell-Derived Definitive Haematopoietic Progenitor Cells by Nafria i Fedi, Monica

“…The t(8;21) translocation generates the aberrant transcription factor RUNX1-ETO and occurs in approximately 10% of all acute myeloid leukaemias. RUNX1-ETO…”
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