Search Results - "Naesens, L"

Diagnosis and immunosuppressive treatment of inflammatory cardiomyopathy: a case report by Naesens, L, Penicka, M, Heggermont, W

“…: Definite diagnosis of myocarditis requires an endomyocardial biopsy (EMB) showing an inflammatory infiltrate. However, there are important limitations on…”
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A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents by Rogolino, D., Carcelli, M., Bacchi, A., Compari, C., Contardi, Laura, Fisicaro, E., Gatti, A., Sechi, M., Stevaert, A., Naesens, L.

“…Acylhydrazones are very versatile ligands and their coordination properties can be easily tuned, giving rise to metal complexes with different nuclearities. In…”
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A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation by Tavernier, S. J., Athanasopoulos, V., Verloo, P., Behrens, G., Staal, J., Bogaert, D. J., Naesens, L., De Bruyne, M., Van Gassen, S., Parthoens, E., Ellyard, J., Cappello, J., Morris, L. X., Van Gorp, H., Van Isterdael, G., Saeys, Y., Lamkanfi, M., Schelstraete, P., Dehoorne, J., Bordon, V., Van Coster, R., Lambrecht, B. N., Menten, B., Beyaert, R., Vinuesa, C. G., Heissmeyer, V., Dullaers, M., Haerynck, F.

“…Hyperinflammatory syndromes are life-threatening disorders caused by overzealous immune cell activation and cytokine release, often resulting from defects in…”
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Antiviral therapy for adenovirus infections by Lenaerts, L., Naesens, L.

“…The treatment of severe adenovirus keratoconjunctivitis and life-threatening adenovirus infections in immunocompromised patients is still unsatisfactory. We…”
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Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues by NAESENS, L, LENAERTS, L, ANDREI, G, SNOECK, R, VAN BEERS, D, HOLY, Antonin, BALZARINI, Jan, DE CLERCQ, Erik

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Antiviral activity and metal ion-binding properties of some 2-hydroxy-3-methoxyphenyl acylhydrazones by Carcelli, M., Fisicaro, E., Compari, C., Contardi, L., Rogolino, D., Solinas, C., Stevaert, A., Naesens, L.

“…Here we report on the results obtained from an antiviral screening, including herpes simplex virus, vaccinia virus, vesicular stomatitis virus, Coxsackie B4…”
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Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation by Tavernier, S. J., Athanasopoulos, V., Verloo, P., Behrens, G., Staal, J., Bogaert, D. J., Naesens, L., De Bruyne, M., Van Gassen, S., Parthoens, E., Ellyard, J., Cappello, J., Morris, L. X., Van Gorp, H., Van Isterdael, G., Saeys, Y., Lamkanfi, M., Schelstraete, P., Dehoorne, J., Bordon, V., Van Coster, R., Lambrecht, B. N., Menten, B., Beyaert, R., Vinuesa, C. G., Heissmeyer, V., Dullaers, M., Haerynck, F.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections by LENAERTS, L, VERBEKEN, E, DE CLERCQ, E, NAESENS, L

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Recovery of Humoral Immunity Is Critical for Successful Antiviral Therapy in Disseminated Mouse Adenovirus Type 1 Infection by LENAERTS, L, KELCHTERMANS, H, GEBOES, L, MATTHYS, P, VERBEKEN, E, DE CLERCQ, E, NAESENS, L

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Intestinal Absorption Enhancement of the Ester Prodrug Tenofovir Disoproxil Fumarate through Modulation of the Biochemical Barrier by Defined Ester Mixtures by VAN GELDER, J, DEFERME, S, NAESENS, L, DE CLERCQ, E, VAN DEN MOOTER, G, KINGET, R, AUGUSTIJNS, P

“…The effect of discrete esters and ester mixtures on the intestinal stability and absorption of tenofovir disoproxil fumarate (tenofovir DF, an…”
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Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine by BALZARINI, J, HOLLY, A, JINDRICH, J, NAESENS, L, SNOECK, R, SCHOLS, D, DE CLERCQ, E

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Adefovir serum levels do not differ between responders and nonresponders by Deterding, K., Naesens, L., Buti, M., Janssen, H., Kirschner, J., Guerrero, A., Reijnders, J., Neyts, J., Zoulim, F., Wedemeyer, H.

“…Primary or secondary failure of adefovir dipivoxil (ADV) therapy of chronic hepatitis B is not infrequent. The reasons for suboptimal responses are not well…”
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Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor by Lenaerts, L., Daelemans, D., Geukens, N., De Clercq, E., Naesens, L.

“…Common human adenovirus (Ad) vectors are derived from serotype 2 or 5, which use the coxsackie-adenovirus receptor (CAR) as their primary cell receptor. We…”
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Role of MRP4 and MRP5 in biology and chemotherapy by Sampath, J, Adachi, M, Hatse, S, Naesens, L, Balzarini, J, Flatley, R M, Matherly, L H, Schuetz, J D

“…Nucleotide efflux (especially cyclic nucleotides) from a variety of mammalian tissues, bacteria, and lower eukaryotes has been studied for several decades…”
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Mechanism of Anti-HIV Action of Masked Alaninyl d4T-Mp Derivatives by Balzarini, J., Karlsson, A., Aquaro, S., C.-F. Perno, Cahard, D., Naesens, L., De Clercq, E., McGuigan, C.

“…So324 is a 2′,3′-dideoxy-2$^{ \prime}$,3′-didehydrothymidine-5$^{ \prime}$-monophosphate (d4T-MP) prodrug containing at the phosphate moiety a phenyl group and…”
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Recent developments in herpesvirus therapy by Naesens, L, De Clercq, E

“…The antiherpes drugs, aciclovir and ganciclovir, are considered the standard treatments and prophylactic agents for infections caused by herpes simplex virus…”
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ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES by De Clercq, Erik, Andrei, G., Balzarini, J., Leyssen, P., Naesens, L., Neyts, J., Pannecouque, C., Snoeck, R., Ying, C., Hocková, D., Holý, A.

“…Three acyclic nucleoside phosphonates (ANPs) have been formally approved for clinical use in the treatment of 1) cytomegalovirus retinitis in AIDS patients…”
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Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781 by Deferme, S, Van Gelder, J, Ingels, F, Van den Mooter, G, De Buck, S, Balzarini, J, Naesens, L, De Clercq, E, Kinget, R, Augustijns, P

“…The aim of this study was to determine the intestinal absorption characteristics of the antiviral agent UC-781 and to optimize the experimental conditions of…”
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6-[2-Phosphonomethoxy)Alkoxy]-2,4-Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity by Balzarini, J., Pannecouque, C., Naesens, L., Andrei, G., Snoeck, R., De Clercq, E., Hocková, D., Holý, A.

“…Acyclic nucleoside phosphonate derivatives containing a pyrimidine base preferably bearing amino groups at C-2 and C-4 (DAPym), and linked at the C-6 position…”
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Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine by NAESENS, L, BALZARINI, J, BISCHOPFBERGER, N, DE CLERCQ, E

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