Search Results - "Nadler, L. M"

Alloanergization of Human T Cells Results in Expansion of Alloantigen‐Specific CD8+CD28− Suppressor Cells by Barbon, C. M., Davies, J. K., Voskertchian, A., Kelner, R. H., Brennan, L. L., Nadler, L. M., Guinan, E. C.

“…Allostimulation with concurrent costimulatory blockade induces alloantigen‐specific hyporesponsiveness in responder T cells (“alloanergization”). Alloanergized…”
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Transplantation of Anergic Histoincompatible Bone Marrow Allografts by Guinan, Eva C, Boussiotis, Vassiliki A, Neuberg, Donna, Brennan, Lisa LaVita, Hirano, Naoto, Nadler, Lee M, Gribben, John G

“…Successful transplantation of organs requires the use of agents capable of suppressing the immune response against alloantigens. 1 – 3 Use of these nonspecific…”
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Human T-Cell Clonal Anergy is Induced by Antigen Presentation in the Absence of B7 Costimulation by Gimmi, Claude D., Freeman, Gordon J., Gribben, John G., Gray, Gary, Nadler, Lee M.

“…The maximal T-cell response to its antigen requires presentation of the antigen by a major histocompatibility complex class II molecule as well as the delivery…”
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Pivotal Role of the B7:CD28 Pathway in Transplantation Tolerance and Tumor Immunity by Guinan, Eva C., Gribben, John G., Boussiotis, Vicki A., Freeman, Gordon J., Nadler, Lee M.

“…The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that…”
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Maintenance of human T cell anergy : Blocking of IL-2 gene transcription by activated Rap1 by BOUSSIOTIS, V. A, FREEMAN, G. J, BEREZOVSKAYA, A, BARBER, D. L, NADLER, L. M

“…In the absence of costimulation, T cells activated through their antigen receptor become unresponsive (anergic) and do not transcribe the gene encoding…”
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High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission by Freedman, A S, Neuberg, D, Gribben, J G, Mauch, P, Soiffer, R J, Fisher, D C, Anderson, K C, Andersen, N, Schlossman, R, Kroon, M, Ritz, J, Aster, J, Nadler, L M

“…The role for high-dose therapy and autologous stem-cell transplantation in mantle-cell lymphoma (MCL) is unknown. We retrospectively analyzed patients with…”
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Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression by Nabavi, N, Freeman, G. J, Gault, A, Godfrey, D, Nadler, L. M, Glimcher, L. H

“…Class II major histocompatibility complex (MHC) molecules function as antigen-presenting elements as well as signal transducers on B lymphocytes. We previously…”
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Constitutive Expression of B7 Restores Immunogenicity of Tumor Cells Expressing Truncated Major Histocompatibility Complex Class II Molecules by Baskar, Sivasubramanian, Ostrand-Rosenberg, Suzanne, Nabavi, Nasrin, Nadler, Lee M., Freeman, Gordon J., Glimcher, Laurie H.

“…The inability of the autologous host to reject resident tumor cells is frequently the result of inadequate generation of tumor-specific T cells. Specific…”
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Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients by Maecker, B., Von Bergwelt‐Baildon, M. S., Anderson, K. S., Vonderheide, R. H., Anderson, K. C., Nadler, L. M., Schultze, J. L.

“…Summary The widely expressed tumour antigens hTERT and CYP1B1 are commonly expressed in multiple myeloma (MM) cells. Several trials targeting these antigens by…”
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Cloning of B7-2: A CTLA-4 Counter-Receptor that Costimulates Human T Cell Proliferation by Freeman, Gordon J., Gribben, John G., Boussiotis, Vassiliki A., Ng, Judy W., Restivo, Vincent A., Lombard, Lisa A., Gray, Gary S., Nadler, Lee M.

“…Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on…”
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Outcome in Patients With Myelodysplastic Syndrome After Autologous Bone Marrow Transplantation for Non-Hodgkin's Lymphoma by FRIEDBERG, J. W, NEUBERG, D, SOIFFER, R. J, FREEDMAN, A. S, STONE, R. M, ALYEA, E, JALLOW, H, LACASCE, A, MAUCH, P. M, GRIBBEN, J. G, RITZ, J, NADLER, L. M

“…The absolute risk of myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for non-Hodgkin's lymphoma (NHL) exceeds 5% in several…”
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Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma by MULTANI, P. S, O'DAY, S, NADLER, L. M, GROSSBARD, M. L

“…Immunotoxins, composed of a monoclonal antibody conjugated to a protein toxin, mediate cell death through novel cytotoxic mechanisms. Anti-B4-blocked ricin…”
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Lymphoma classification : The gap between biology and clinical management is closing by HIDDEMANN, W, LONGO, D. L, COIFFIER, B, FISHER, R. I, CABANILLAS, F, CAVALLI, F, NADLER, L. M, DE VITA, V. T, LISTER, T. A, ARMITAGE, J. O

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Eradication of Polymerase Chain Reaction-Detectable Chronic Lymphocytic Leukemia Cells Is Associated With Improved Outcome After Bone Marrow Transplantation by Provan, Drew, Bartlett-Pandite, Lini, Zwicky, Caroline, Neuberg, Donna, Maddocks, Anne, Corradini, Paolo, Soiffer, Robert, Ritz, Jerome, Nadler, Lee M., Gribben, John G.

“…In chronic lymphocytic leukemia (CLL), clonal rearrangement of the immunoglobulin heavy chain locus (IgH) provides a useful marker for the detection of minimal…”
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Human CD100, a Novel Leukocyte Semaphorin that Promotes B-Cell Aggregation and Differentiation by Hall, Kathryn T., Boumsell, Laurence, Schultze, Joachim L., Boussiotis, Vassiliki A., Dorfman, David M., Cardoso, Angelo A., Bensussan, Armand, Nadler, Lee M., Freeman, Gordon J.

“…Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in…”
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High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission by FREEDMAN, A. S, GRIBBEN, J. G, NADLER, L. M, NEUBERG, D, MAUCH, P, SOIFFER, R. J, ANDERSON, K. C, PANDITE, L, ROBERTSON, M. J, KROON, M, RITZ, J

“…We report the results of a study in previously untreated advanced stage patients with follicular lymphoma (FL) who underwent uniform induction chemotherapy…”
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Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation by BOUSSIOTIS, V. A, FREEMAN, G. J, GRIBBEN, J. G, DALEY, J, GRAY, G, NADLER, L. M

“…Signaling via the T-cell receptor complex is necessary but not sufficient to induce antigen-specific T lymphocytes to expand clonally. To proliferate, T cells…”
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Prevention of T Cell Anergy by Signaling Through the $\gamma_c$ Chain of the IL-2 Receptor by Boussiotis, Vassiliki A., Barber, Dwayne L., Nakarai, Takayuki, Freeman, Gordon J., Gribben, John G., Bernstein, Gregory M., D'Andrea, Alan D., Ritz, Jerome, Nadler, Lee M.

“…When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In…”
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B7-mediated costimulation and the immune response by Schultze, J., Nadler, L.M., Gribben, J.G.

“…In addition to presentation of antigen, T cells require additional or ‘costimulatory’ signals from antigen-presenting cells. Failure to receive costimulation…”
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Monoclonal Antibody-Based Therapies of Leukemia and Lymphoma by Grossbard, Michael L., Press, Oliver W., Appelbaum, Frederick R., Bernstein, Irwin D., Nadler, Lee M.

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