Search Results - "Nadler, J Victor"

The recurrent mossy fiber pathway of the epileptic brain by Nadler, J Victor

“…The dentate gyrus is believed to play a key role in the pathogenesis of temporal lobe epilepsy. In normal brain the dentate granule cells serve as a…”
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Enhanced Tonic GABA Current in Normotopic and Hilar Ectopic Dentate Granule Cells After Pilocarpine-Induced Status Epilepticus by Zhan, Ren-Zhi, Nadler, J. Victor

“…Department of Pharmacology and Cancer Biology and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina Submitted 18 February…”
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High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats by Zhan, Ren-Zhi, Timofeeva, Olga, Nadler, J Victor

“…After experimental status epilepticus, many dentate granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar…”
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Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat by Gao, Fei, Song, Xueying, Zhu, Dexiao, Wang, Xiaochen, Hao, Aijun, Nadler, J Victor, Zhan, Ren-Zhi

“…To understand the potential role of enhanced hippocampal neurogenesis after pilocarpine-induced status epilepticus (SE) in the development of epilepsy, we…”
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Persistent Hyperactivity of Hippocampal Dentate Interneurons After a Silent Period in the Rat Pilocarpine Model of Epilepsy by Wang, Xiaochen, Song, Xinyu, Wu, Lin, Nadler, J Victor, Zhan, Ren-Zhi

“…Profile of GABAergic interneuron activity after pilocarpine-induced status epilepticus (SE) was examined in the rat hippocampal dentate gyrus by analyzing…”
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Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models by Dingledine, Raymond, Coulter, Douglas A., Fritsch, Brita, Gorter, Jan A., Lelutiu, Nadia, McNamara, James, Nadler, J. Victor, Pitkänen, Asla, Rogawski, Michael A., Skene, Pate, Sloviter, Robert S., Wang, Yu, Wadman, Wytse J., Wasterlain, Claude, Roopra, Avtar

“…Global expression profiling of neurologic or psychiatric disorders has been confounded by variability among laboratories, animal models, tissues sampled, and…”
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Neuropeptide Y in the recurrent mossy fiber pathway by Nadler, J. Victor, Tu, Bin, Timofeeva, Olga, Jiao, Yiqun, Herzog, Herbert

“…In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is…”
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Short-Term Frequency-Dependent Plasticity at Recurrent Mossy Fiber Synapses of the Epileptic Brain by Feng, Li, Molnar, Peter, Nadler, J. Victor

“…The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in human temporal lobe epilepsy and in animal models of this disorder, creating…”
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Mechanisms of increased hippocampal excitability in the Mashl+/− mouse model of Na+/K+‐ATPase dysfunction by Hunanyan, Arsen S., Helseth, Ashley R., Abdelnour, Elie, Kherallah, Bassil, Sachdev, Monisha, Chung, Leeyup, Masoud, Melanie, Richardson, Jordan, Li, Qiang, Nadler, J. Victor, Moore, Scott D., Mikati, Mohamad A.

“…Summary Objective Na+/K+‐ATPase dysfunction, primary (mutation) or secondary (energy crisis, neurodegenerative disease) increases neuronal excitability in the…”
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Aspartate Release and Signalling in the Hippocampus by Nadler, J. Victor

“…The Ca 2+ -dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process…”
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Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy by Cameron, Michael C., Zhan, Ren-Zhi, Nadler, J. Victor

“…After pilocarpine‐induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar ectopic…”
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Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: Correlation of cell loss with mossy fiber sprouting by Jiao, Yiqun, Nadler, J. Victor

“…Mossy fiber sprouting and the genesis of ectopic granule cells contribute to reverberating excitation in the dentate gyrus of epileptic brain. This study…”
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What is a seizure focus? by Nadler, J Victor, Spencer, Dennis D

“…The seizure focus is the site in the brain from which the seizure originated and is most likely equivalent to the epileptogenic zone, defined as the area of…”
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Plasticity of glutamate synaptic mechanisms by Victor Nadler, J.

“…Summary Enhanced glutamate synaptic transmission may be expected to alter the balance of excitation and inhibition in brain, leading to seizures. Several…”
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Spontaneous Release of Neuropeptide Y Tonically Inhibits Recurrent Mossy Fiber Synaptic Transmission in Epileptic Brain by Tu, Bin, Timofeeva, Olga, Jiao, Yiqun, Nadler, J. Victor

“…In the pilocarpine model of temporal lobe epilepsy, mossy fibers coexpress the inhibitory transmitter neuropeptide Y (NPY) with glutamate. The effects of…”
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Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: Evidence for an exocytotic mechanism by Wang, Lulu, Nadler, J. Victor

“…Aspartate can be released from certain hippocampal pathways along with glutamate or GABA. Although aspartate immunoreactivity has been localized to synaptic…”
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Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release by Zhang, Xuying, Nadler, J. Victor

“…Abstract Aspartate satisfies all the criteria normally required for identification of a CNS neurotransmitter. Nevertheless, little electrophysiological…”
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Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry by Ribak, Charles E., Tran, Peter H., Spigelman, Igor, Okazaki, Maxine M., Nadler, J. Victor

“…Mossy fiber sprouting into the inner molecular layer of the dentate gyrus is an important neuroplastic change found in animal models of temporal lobe epilepsy…”
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The gene encoding proline dehydrogenase modulates sensorimotor gating in mice by Karayiorgou, Maria, Gogos, Joseph, Santha, Miklos, Takacs, Zoltan, Beck, Kevin D, Luine, Victoria, Lucas, Louis R, Nadler, J. Victor

“…Hemizygous cryptic deletions of the q11 band of human chromosome 22 have been associated with a number of psychiatric and behavioural phenotypes, including…”
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Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia by Zhan, Ren-Zhi, Nadler, J Victor, Schwartz-Bloom, Rochelle D

“…Although interneurons in area CA1 of the hippocampus are less vulnerable to cerebral ischemia than CA1 pyramidal cells, it is not clear whether their…”
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