Search Results - "Nadjsombati, Marija S"

Tuning tuft cells: new ligands and effector functions reveal tissue-specific function by Billipp, Tyler E, Nadjsombati, Marija S, von Moltke, Jakob

“…•Tuft cells reside in the epithelium of airway, intestinal, and urogenital tissues.•Tuft cell receptors and effector functions are tuned in a tissue-specific…”
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Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit by Nadjsombati, Marija S., McGinty, John W., Lyons-Cohen, Miranda R., Jaffe, James B., DiPeso, Lucian, Schneider, Christoph, Miller, Corey N., Pollack, Joshua L., Nagana Gowda, G.A., Fontana, Mary F., Erle, David J., Anderson, Mark S., Locksley, Richard M., Raftery, Daniel, von Moltke, Jakob

“…In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2s). Here, we…”
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PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection by Oyesola, Oyebola O, Shanahan, Michael T, Kanke, Matt, Mooney, Bridget M, Webb, Lauren M, Smita, Shuchi, Matheson, Macy K, Campioli, Pamela, Pham, Duc, Früh, Simon P, McGinty, John W, Churchill, Madeline J, Cahoon, Jordan L, Sundaravaradan, Pavithra, Flitter, Becca A, Mouli, Karthik, Nadjsombati, Marija S, Kamynina, Elena, Peng, Seth A, Cubitt, Rebecca L, Gronert, Karsten, Lord, James D, Rauch, Isabella, von Moltke, Jakob, Sethupathy, Praveen, Tait Wojno, Elia D

“…Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth…”
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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons by Forero, Adriana, Ozarkar, Snehal, Li, Hongchuan, Lee, Chia Heng, Hemann, Emily A., Nadjsombati, Marija S., Hendricks, Matthew R., So, Lomon, Green, Richard, Roy, Chandra N., Sarkar, Saumendra N., von Moltke, Jakob, Anderson, Stephen K., Gale, Michael, Savan, Ram

“…Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike type I IFNs, type III IFNs (IFNλ) do not elicit strong…”
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Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8 + T cells by Omilusik, Kyla D, Nadjsombati, Marija S, Shaw, Laura A, Yu, Bingfei, Milner, J Justin, Goldrath, Ananda W

“…CD8 T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate,…”
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Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity by Omilusik, Kyla D, Nadjsombati, Marija S, Yoshida, Tomomi M, Shaw, Laura A, Goulding, John, Goldrath, Ananda W

“…T cells are essential mediators of immune responses against infectious diseases and provide long-lived protection from reinfection. The differentiation of…”
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Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity by McGinty, John W., Ting, Hung-An, Billipp, Tyler E., Nadjsombati, Marija S., Khan, Danish M., Barrett, Nora A., Liang, Hong-Erh, Matsumoto, Ichiro, von Moltke, Jakob

“…Helminths, allergens, and certain protists induce type 2 immune responses, but the underlying mechanisms of immune activation remain poorly understood. In the…”
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Genetic mapping reveals Pou2af2/ OCA-T1-dependent tuning of tuft cell differentiation and intestinal type 2 immunity by Nadjsombati, Marija S, Niepoth, Natalie, Webeck, Lily M, Kennedy, Elizabeth A, Jones, Danielle L, Billipp, Tyler E, Baldridge, Megan T, Bendesky, Andres, von Moltke, Jakob

“…Chemosensory epithelial tuft cells contribute to innate immunity at barrier surfaces, but their differentiation from epithelial progenitors is not well…”
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