Case-control study on post-COVID-19 conditions reveals severe acute infection and chronic pulmonary disease as potential risk factors

Post-COVID-19 conditions (long COVID) has impacted many individuals, yet risk factors for this condition are poorly understood. This retrospective analysis of 88,943 COVID-19 patients at a multi-state US health system compares phenotypes, laboratory tests, medication orders, and outcomes for 1,086 l...

Full description

Saved in:

Bibliographic Details
Published in:	iScience Vol. 27; no. 8; p. 110406
Main Authors:	Ghosh, Pritha, Niesen, Michiel J.M., Pawlowski, Colin, Bandi, Hari, Yoo, Unice, Lenehan, Patrick J., Kumar-M, Praveen, Nadig, Mihika, Ross, Jason, Ardhanari, Sankar, O’Horo, John C., Venkatakrishnan, A.J., Rosen, Clifford J., Telenti, Amalio, Hurt, Ryan T., Soundararajan, Venky
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 16-08-2024 Elsevier
Subjects:	Immunology Public health Respiratory medicine Respiratory medicine Public health Immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Post-COVID-19 conditions (long COVID) has impacted many individuals, yet risk factors for this condition are poorly understood. This retrospective analysis of 88,943 COVID-19 patients at a multi-state US health system compares phenotypes, laboratory tests, medication orders, and outcomes for 1,086 long-COVID patients and their matched controls. We found that history of chronic pulmonary disease (CPD) (odds ratio: 1.9, 95% CI: [1.5, 2.6]), migraine (OR: 2.2, [1.6, 3.1]), and fibromyalgia (OR: 2.3, [1.3, 3.8]) were more common for long-COVID patients. During the acute infection phase long COVID patients exhibited high triglycerides, low HDL cholesterol, and a high neutrophil-lymphocyte ratio; and were more likely hospitalized (5% vs. 1%). Our findings suggest severity of acute infection and history of CPD, migraine, chronic fatigue syndrome (CFS), or fibromyalgia as risk factors for long COVID. These results suggest that suppressing acute disease severity proactively, especially in patients at high risk, can reduce incidence of long COVID. [Display omitted] •Compared EHR data for 1,086 patients with/without post-COVID conditions•Post-COVID conditions linked to chronic pulmonary disease, migraine, and fibromyalgia•Post-COVID conditions linked to elevated inflammation markers•Patients with post-COVID conditions showed more severe acute COVID symptoms Immunology; Respiratory medicine; Public health
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally Lead contact
ISSN:	2589-0042 2589-0042
DOI:	10.1016/j.isci.2024.110406