Search Results - "Nadia R. Roan"

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons by Kong, Weili, Montano, Mauricio, Corley, Michael J, Helmy, Ekram, Kobayashi, Hirofumi, Kinisu, Martin, Suryawanshi, Rahul, Luo, Xiaoyu, Royer, Loic A, Roan, Nadia R, Ott, Melanie, Ndhlovu, Lishomwa C, Greene, Warner C

“…Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status by Neidleman, Jason, Luo, Xiaoyu, McGregor, Matthew, Xie, Guorui, Murray, Victoria, Greene, Warner C, Lee, Sulggi A, Roan, Nadia R

“…While mRNA vaccines are proving highly efficacious against SARS-CoV-2, it is important to determine how booster doses and prior infection influence the immune…”
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SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential by Neidleman, Jason, Luo, Xiaoyu, Frouard, Julie, Xie, Guorui, Gill, Gurjot, Stein, Ellen S., McGregor, Matthew, Ma, Tongcui, George, Ashley F., Kosters, Astrid, Greene, Warner C., Vasquez, Joshua, Ghosn, Eliver, Lee, Sulggi, Roan, Nadia R.

“…Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell responses against SARS-CoV-2, suggesting an important role of T cells in viral…”
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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells by Adeniji, Opeyemi S, Kuri-Cervantes, Leticia, Yu, Chenfei, Xu, Ziyang, Ho, Michelle, Chew, Glen M, Shikuma, Cecilia, Tomescu, Costin, George, Ashley F, Roan, Nadia R, Ndhlovu, Lishomwa C, Liu, Qin, Muthumani, Kar, Weiner, David B, Betts, Michael R, Xiao, Han, Abdel-Mohsen, Mohamed

“…Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to…”
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Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection by Roan, Nadia R., Müller, Janis A., Liu, Haichuan, Chu, Simon, Arnold, Franziska, Stürzel, Christina M., Walther, Paul, Dong, Ming, Witkowska, H. Ewa, Kirchhoff, Frank, Münch, Jan, Greene, Warner C.

“…Semen serves as a vehicle for HIV and promotes sexual transmission of the virus, which accounts for the majority of new HIV cases. The major component of semen…”
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Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir by Neidleman, Jason, Luo, Xiaoyu, Frouard, Julie, Xie, Guorui, Hsiao, Feng, Ma, Tongcui, Morcilla, Vincent, Lee, Ashley, Telwatte, Sushama, Thomas, Reuben, Tamaki, Whitney, Wheeler, Benjamin, Hoh, Rebecca, Somsouk, Ma, Vohra, Poonam, Milush, Jeffrey, James, Katherine Sholtis, Archin, Nancie M, Hunt, Peter W, Deeks, Steven G, Yukl, Steven A, Palmer, Sarah, Greene, Warner C, Roan, Nadia R

“…The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the in vivo reservoir have…”
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Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection by Hsiao, Feng, Frouard, Julie, Gramatica, Andrea, Xie, Guorui, Telwatte, Sushama, Lee, Guinevere Q, Roychoudhury, Pavitra, Schwarzer, Roland, Luo, Xiaoyu, Yukl, Steven A, Lee, Sulggi, Hoh, Rebecca, Deeks, Steven G, Jones, R Brad, Cavrois, Marielle, Greene, Warner C, Roan, Nadia R

“…The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than…”
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SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice by Lee, Katherine S, Wong, Ting Y, Russ, Brynnan P, Horspool, Alexander M, Miller, Olivia A, Rader, Nathaniel A, Givi, Jerome P, Winters, Michael T, Wong, Zeriel Y A, Cyphert, Holly A, Denvir, James, Stoilov, Peter, Barbier, Mariette, Roan, Nadia R, Amin, Md Shahrier, Martinez, Ivan, Bevere, Justin R, Damron, F Heath

“…The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other…”
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Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV by Ma, Tongcui, McGregor, Matthew, Giron, Leila, Xie, Guorui, George, Ashley F, Abdel-Mohsen, Mohamed, Roan, Nadia R

“…High-parameter single-cell phenotyping has enabled in-depth classification and interrogation of immune cells, but to date has not allowed for glycan…”
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HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread by Ma, Tongcui, Luo, Xiaoyu, George, Ashley F, Mukherjee, Gourab, Sen, Nandini, Spitzer, Trimble L, Giudice, Linda C, Greene, Warner C, Roan, Nadia R

“…The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of…”
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Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood by Vallvé-Juanico, Júlia, George, Ashley F, Sen, Sushmita, Thomas, Reuben, Shin, Min-Gyoung, Kushnoor, Divyashree, Vásquez, Joshua J, Vo, Kim Chi, Irwin, Juan C, Roan, Nadia R, Combes, Alexis J, Giudice, Linda C

“…Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune…”
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Seminal Plasma and Semen Amyloids Enhance Cytomegalovirus Infection in Cell Culture by Tang, Qiyi, Roan, Nadia R, Yamamura, Yasuhiro

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The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency by Sperber, Hannah S., Raymond, Kyle A., Bouzidi, Mohamed S., Ma, Tongcui, Valdebenito, Silvana, Eugenin, Eliseo A., Roan, Nadia R., Deeks, Steven G., Winning, Sandra, Fandrey, Joachim, Schwarzer, Roland, Pillai, Satish K.

“…Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for human immunodeficiency virus (HIV) infection. Here, we implement a…”
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Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells by Cavrois, Marielle, Banerjee, Trambak, Mukherjee, Gourab, Raman, Nandhini, Hussien, Rajaa, Rodriguez, Brandon Aguilar, Vasquez, Joshua, Spitzer, Matthew H., Lazarus, Nicole H., Jones, Jennifer J., Ochsenbauer, Christina, McCune, Joseph M., Butcher, Eugene C., Arvin, Ann M., Sen, Nandini, Greene, Warner C., Roan, Nadia R.

“…To characterize susceptibility to HIV infection, we phenotyped infected tonsillar T cells by single-cell mass cytometry and created comprehensive maps to…”
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Semen inhibits Zika virus infection of cells and tissues from the anogenital region by Müller, Janis A., Harms, Mirja, Krüger, Franziska, Groß, Rüdiger, Joas, Simone, Hayn, Manuel, Dietz, Andrea N., Lippold, Sina, von Einem, Jens, Schubert, Axel, Michel, Manuela, Mayer, Benjamin, Cortese, Mirko, Jang, Karen S., Sandi-Monroy, Nathallie, Deniz, Miriam, Ebner, Florian, Vapalahti, Olli, Otto, Markus, Bartenschlager, Ralf, Herbeuval, Jean-Philippe, Schmidt-Chanasit, Jonas, Roan, Nadia R., Münch, Jan

“…Zika virus (ZIKV) causes severe birth defects and can be transmitted via sexual intercourse. Semen from ZIKV-infected individuals contains high viral loads and…”
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The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection by ROAN, Nadia R, MÜNCH, Jan, ARHEL, Nathalie, MOTHES, Walther, NEIDLEMAN, Jason, KOBAYASHI, Akiko, SMITH-MCCUNE, Karen, KIRCHHOFF, Frank, GREENE, Warner C

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Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection by Giron, Leila B., Liu, Qin, Adeniji, Opeyemi S., Yin, Xiangfan, Kannan, Toshitha, Ding, Jianyi, Lu, David Y., Langan, Susan, Zhang, Jinbing, Azevedo, Joao L. L. C., Li, Shuk Hang, Shalygin, Sergei, Azadi, Parastoo, Hanna, David B., Ofotokun, Igho, Lazar, Jason, Fischl, Margaret A., Haberlen, Sabina, Macatangay, Bernard, Adimora, Adaora A., Jamieson, Beth D., Rinaldo, Charles, Merenstein, Daniel, Roan, Nadia R., Kutsch, Olaf, Gange, Stephen, Wolinsky, Steven M., Witt, Mallory D., Post, Wendy S., Kossenkov, Andrew, Landay, Alan L., Frank, Ian, Tien, Phyllis C., Gross, Robert, Brown, Todd T., Abdel-Mohsen, Mohamed

“…People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is…”
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No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells by McGinnis, Christopher S, Siegel, David A, Xie, Guorui, Hartoularos, George, Stone, Mars, Ye, Chun J, Gartner, Zev J, Roan, Nadia R, Lee, Sulggi A

“…Single-cell RNA sequencing (scRNA-seq) provides high-dimensional measurements of transcript counts in individual cells. However, high assay costs and artifacts…”
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Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo by Cavrois, Marielle, Hilton, Joan F, Roan, Nadia R, Takeda, Margaret, Seidman, Dominika, Averbach, Sarah, Chang, Eric, Raman, Nandhini, Greenblatt, Ruth, Shacklett, Barbara L, Smith-McCune, Karen

“…Globally, HIV/AIDS is a leading cause of morbidity worldwide among reproductive-aged cisgender women, highlighting the importance of understanding effects of…”
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Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq by Luo, Xiaoyu, Frouard, Julie, Zhang, Gang, Neidleman, Jason, Xie, Guorui, Sheedy, Emma, Roan, Nadia R, Greene, Warner C

“…CD4 T lymphocytes belong to diverse cellular subsets whose sensitivity or resistance to HIV-associated killing remains to be defined. Working with lymphoid…”
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