Search Results - "Nadesan, Puviindran"

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair by Yahara, Yasuhito, Barrientos, Tomasa, Tang, Yuning J., Puviindran, Vijitha, Nadesan, Puviindran, Zhang, Hongyuan, Gibson, Jason R., Gregory, Simon G., Diao, Yarui, Xiang, Yu, Qadri, Yawar J., Souma, Tomokazu, Shinohara, Mari L., Alman, Benjamin A.

“…Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing…”
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Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice by Vi, Linda, Baht, Gurpreet S., Soderblom, Erik J., Whetstone, Heather, Wei, Qingxia, Furman, Bridgette, Puviindran, Vijitha, Nadesan, Puviindran, Foster, Matthew, Poon, Raymond, White, James P., Yahara, Yasuhito, Ng, Adeline, Barrientos, Tomasa, Grynpas, Marc, Mosely, M. Arthur, Alman, Benjamin A.

“…The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for…”
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Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis by Tsushima, Hidetoshi, Tang, Yuning J, Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J, Hilton, Matthew J, Alman, Benjamin A

“…During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated…”
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing by Chen, Yan, Whetstone, Heather C, Lin, Alvin C, Nadesan, Puviindran, Wei, Qingxia, Poon, Raymond, Alman, Benjamin A

“…Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair…”
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Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery by Amini-Nik, Saeid, Kraemer, Darren, Cowan, Michael L, Gunaratne, Keith, Nadesan, Puviindran, Alman, Benjamin A, Miller, R J Dwayne

“…Lasers have in principle the capability to cut at the level of a single cell, the fundamental limit to minimally invasive procedures and restructuring…”
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Mutant IDH is sufficient to initiate enchondromatosis in mice by Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

“…Significance Current genomic and biochemical analysis revealed mutations in isocitrate dehydrogenase ( IDH ) genes associated with several neoplasms and a…”
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Aggressive Fibromatosis (Desmoid Tumor) Is Derived from Mesenchymal Progenitor Cells by WU, Colleen, NIK-AMINI, Saied, NADESAN, Puviindran, STANFORD, William L, ALMAN, Benjamin A

“…The cellular origins from which most tumors arise are poorly defined, especially in mesenchymal neoplasms. Aggressive fibromatosis, also known as desmoid…”
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Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation by Pathmanapan, Sinthu, Poon, Raymond, De Renshaw, Tomasa Barrientos, Nadesan, Puviindran, Nakagawa, Makoto, Seesankar, Gireesh A., Loe, Adrian Kwan Ho, Zhang, Hongyuan H., Guinovart, Joan J., Duran, Jordi, Newgard, Christopher B., Wunder, Jay S., Alman, Benjamin A.

“…Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes…”
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Side population cells isolated from mesenchymal neoplasms have tumor initiating potential by WU, Colleen, QINGXIA WEI, UTOMO, Velani, NADESAN, Puviindran, WHETSTONE, Heather, KANDEL, Rita, WUNDER, Jay S, ALMAN, Benjamin A

“…Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface…”
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Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage by Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Puviindran, Vijitha, Stallcup, William B., Kirsch, David G., Alman, Benjamin A.

“…Sarcomas, and the mesenchymal precursor cells from which they arise, express chondroitin sulfate proteoglycan 4 (NG2/CSPG4). However, NG2/CSPG4's function and…”
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Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation by Baht, Gurpreet S, Silkstone, David, Nadesan, Puviindran, Whetstone, Heather, Alman, Benjamin A

“…ABSTRACT Fracture repair is a well orchestrated process involving various cell types and signaling molecules. The hedgehog signaling pathway is activated in…”
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Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth by Campbell, Veronica T, Nadesan, Puviindran, Ali, S Amanda, Wang, Chang Ye Yale, Whetstone, Heather, Poon, Raymond, Wei, Qingxia, Keilty, John, Proctor, Jennifer, Wang, Lauren W, Apte, Suneel S, McGovern, Karen, Alman, Benjamin A, Wunder, Jay S

“…Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either…”
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β-Catenin Stabilization Dysregulates Mesenchymal Cell Proliferation, Motility, and Invasiveness and Causes Aggressive Fibromatosis and Hyperplastic Cutaneous Wounds by Cheon, Sophia S., Alexander Y. L. Cheah, Turley, Stefanie, Nadesan, Puviindran, Poon, Raymond, Clevers, Hans, Alman, Benjamin A.

“…Fibroproliferative processes are a group of disorders in which there is excessive proliferation of spindle (mesenchymal fibroblast-like) cells. They range from…”
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Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma by Tang, Yuning Jackie, Puviindran, Vijitha, Xiang, Yu, Yahara, Yasuhito, Zhang, Hongyuan, Nadesan, Puviindran, Diao, Yarui, Kirsch, David G, Alman, Benjamin A

“…Sarcomas contain a subpopulation of tumor-propagating cells (TPCs) with enhanced tumor-initiating and self-renewal properties. However, it is unclear whether…”
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Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor) by FEN LI, Catherine, KANDEL, Christopher, BALIKO, Frank, NADESAN, Puviindran, BRÜNNER, Nils, ALMAN, Benjamin A

“…Aggressive fibromatosis is a mesenchymal neoplasm associated with mutations, resulting in beta-catenin-mediated transcriptional activation. We found that…”
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Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin by Baht, Gurpreet S, Silkstone, David, Vi, Linda, Nadesan, Puviindran, Amani, Yasha, Whetstone, Heather, Wei, Qingxia, Alman, Benjamin A

“…The capacity for tissues to repair and regenerate diminishes with age. We sought to determine the age-dependent contribution of native mesenchymal cells and…”
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β-Catenin-regulated myeloid cell adhesion and migration determine wound healing by Amini-Nik, Saeid, Cambridge, Elizabeth, Yu, Winston, Guo, Anne, Whetstone, Heather, Nadesan, Puviindran, Poon, Raymond, Hinz, Boris, Alman, Benjamin A

“…A β-catenin/T cell factor-dependent transcriptional program is critical during cutaneous wound repair for the regulation of scar size; however, the relative…”
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Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair by Baht, Gurpreet S, Nadesan, Puviindran, Silkstone, David, Alman, Benjamin A

“…Abstract Patients with Neurofibromatosis type 1 display delayed fracture healing and the increased deposition of fibrous tissue at the fracture site. Severe…”
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Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations by Zhang, Hongyuan, Puviindran, Vijitha, Nadesan, Puviindran, Ding, Xiruo, Shen, Leyao, Tang, Yuning J, Tsushima, Hidetoshi, Yahara, Yasuhito, Ban, Ga I, Zhang, Guo‐Fang, Karner, Courtney M, Alman, Benjamin A.

“…ABSTRACT Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor…”
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Erythromyeloid progenitors give rise to a population of osteoclasts contributing to bone homeostasis and repair by Yahara, Yasuhito, Barrientos, Tomasa, Tang, Yuning J., Puviindran, Vijitha, Nadesan, Puviindran, Zhang, Hongyuan, Gibson, Jason, Gregory, Simon G., Diao, Yarui, Xiang, Yu, Qadri, Yawar J., Souma, Tomokazu, Shinohara, Mari L., Alman, Benjamin A.

“…The osteoclast is a multinucleated monocyte/macrophage lineage cell that degrades bone. Here we used lineage tracing studies, labeling cells expressing Cx3cr1…”
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