Which outcomes are most important to measure in patients with COVID-19 and how and when should these be measured? Development of an international standard set of outcomes measures for clinical use in patients with COVID-19: a report of the International Consortium for Health Outcomes Measurement (ICHOM) COVID-19 Working Group

ObjectivesThe COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practices within and between institutions. Outcome measure...

Full description

Saved in:

Bibliographic Details
Published in:	BMJ open Vol. 11; no. 11; p. e051065
Main Authors:	Seligman, William H, Fialho, Luz, Sillett, Nick, Nielsen, Christina, Baloch, Farhala M, Collis, Philip, Demedts, Ingel K M, Fleck, Marcelo P, Floriani, Maiara A, Gabriel, Lucinda E K, Gagnier, Joel J, Keetharuth, Anju, Londral, Ana, Ludwig, Ingvar I L, Lumbreras, Carlos, Moscoso Daza, Alejandro, Muhammad, Nasreen, Nader Bastos, Gisele A, Owen, Christine W, Powers, John H, Russell, Anne-Marie, Smith, Michaela K, Wang, Tracy Y-P, Wong, Evan K, Woodhouse, Douglas C, Zimlichman, Eyal, Brinkman, Kees
Format:	Journal Article
Language:	English
Published:	London British Medical Journal Publishing Group 15-11-2021 BMJ Publishing Group LTD BMJ Publishing Group
Series:	Original research
Subjects:	Cardiovascular disease Clinical outcomes Clinical trials Consortia Coronaviruses COVID-19 international health services Patients Public Health quality in healthcare Quality of life Severe acute respiratory syndrome coronavirus 2 Social networks Systematic review Working groups
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	ObjectivesThe COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practices within and between institutions. Outcome measures vary among clinical trials on the same therapies. Understanding which therapies are of most value is not possible unless consensus can be reached on which outcomes are most important to measure. Furthermore, consensus on the most important outcomes may enable patients to monitor and track their care, and may help providers to improve the care they offer through quality improvement. To develop a standardised minimum set of outcomes for clinical care, the International Consortium for Health Outcomes Measurement (ICHOM) assembled a working group (WG) of 28 volunteers, including health professionals, patients and patient representatives.DesignA list of outcomes important to patients and professionals was generated from a systematic review of the published literature using the MEDLINE database, from review of outcomes being measured in ongoing clinical trials, from a survey distributed to patients and patient networks, and from previously published ICHOM standard sets in other disease areas. Using an online-modified Delphi process, the WG selected outcomes of greatest importance.ResultsThe outcomes considered by the WG to be most important were selected and categorised into five domains: (1) functional status and quality of life, (2) mental functioning, (3) social functioning, (4) clinical outcomes and (5) symptoms. The WG identified demographic and clinical variables for use as case-mix risk adjusters. These included baseline demographics, clinical factors and treatment-related factors.ConclusionImplementation of these consensus recommendations could help institutions to monitor, compare and improve the quality and delivery of care to patients with COVID-19. Their consistent definition and collection could also broaden the implementation of more patient-centric clinical outcomes research.
Bibliography:	Original research ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2021-051065