Search Results - "Nadel, M"

The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state by Lee, Kanghyun, Thwin, Aye C., Nadel, Cory M., Tse, Eric, Gates, Stephanie N., Gestwicki, Jason E., Southworth, Daniel R.

“…The Hsp90 chaperone promotes folding and activation of hundreds of client proteins in the cell through an ATP-dependent conformational cycle guided by distinct…”
Get full text

Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressor by Nadel, Cory M, Mackie, Timothy D, Gardner, Richard G

“…Environmental stressors can severely perturb cellular homeostasis and compromise viability. To cope with environmental stressors, eukaryotes have developed…”
Get full text

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP by Nadel, Cory M., Pokhrel, Saugat, Wucherer, Kristin, Oehler, Abby, Thwin, Aye C., Basu, Koli, Callahan, Matthew D., Southworth, Daniel R., Mordes, Daniel A., Craik, Charles S., Gestwicki, Jason E.

“…Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is…”
Get full text

Minor stable carbon isotope fractionation between respired carbon dioxide and bulk soil organic matter during laboratory incubation of topsoil by Breecker, D. O, Bergel, S, Nadel, M, Tremblay, M. M, Osuna-Orozco, R, Larson, T. E, Sharp, Z. D

“…A common assumption in paleoenvironmental reconstructions using soils is that the carbon isotope composition of soil-respired CO₂is equivalent to the carbon…”
Get full text

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress by Oeser, Michelle L, Amen, Triana, Nadel, Cory M, Bradley, Amanda I, Reed, Benjamin J, Jones, Ramon D, Gopalan, Janani, Kaganovich, Daniel, Gardner, Richard G

“…Cells are often exposed to physical or chemical stresses that can damage the structures of essential biomolecules. Stress-induced cellular damage can become…”
Get full text

Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination by Groves, Benjamin, Khakhar, Arjun, Nadel, Cory M, Gardner, Richard G, Seelig, Georg

“…Evolution has often copied and repurposed the mitogen-activated protein kinase (MAPK) signaling module. Understanding how connections form during evolution, in…”
Get full text

Do Children With Blunt Head Trauma and Normal Cranial Computed Tomography Scan Results Require Hospitalization for Neurologic Observation? by Holmes, James F., MD, MPH, Borgialli, Dominic A., DO, MPH, Nadel, Frances M., MD, MSCE, Quayle, Kimberly S., MD, Schambam, Neil, MD, Cooper, Art, MD, Schunk, Jeff E., MD, Miskin, Michelle L., MS, Atabaki, Shireen M., MD, MPH, Hoyle, John D., MD, Dayan, Peter S., MD, MSc, Kuppermann, Nathan, MD, MPH

“…Study objective Children evaluated in the emergency department (ED) with minor blunt head trauma, defined by initial Glasgow Coma Scale (GCS) scores of 14 or…”
Get full text

The interactions of molecular chaperones with client proteins: why are they so weak? by Arhar, Taylor, Shkedi, Arielle, Nadel, Cory M., Gestwicki, Jason E.

“…The major classes of molecular chaperones have highly variable sequences, sizes, and shapes, yet they all bind to unfolded proteins, limit their aggregation,…”
Get full text

Response to Letter to the Editor Regarding Our Paper, "Patient-Centered Innovation: Involving Patients in Open Social Innovation" by Jung, Olivia S, Kyle, Michael Anne, McCree, Paula, Nadel, Hiyam M

Get full text

Assessing pediatric senior residents’ training in resuscitation: Fund of knowledge, technical skills, and perception of confidence by NADEL, FRANCES M, LAVELLE, JANE M, FEIN, JOEL A, GIARDINO, ANGELO P, DECKER, JOANNE M, DURBIN, DENNIS R

“…OBJECTIVE DESIGN AND PARTICIPANTS METHODS RESULTS CONCLUSION…”
Get full text

Patient-Centered Innovation: Involving Patients in Open Social Innovation by Jung, Olivia S, Kyle, Michael Anne, McCree, Paula, Nadel, Hiyam M

“…Involving patients in the health-care delivery innovation has many benefits. Open social innovation (OSI) presents a fitting lens to examine and advance…”
Get full text

Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities by Johnson, Oleta T., Nadel, Cory M., Carroll, Emma C., Arhar, Taylor, Gestwicki, Jason E.

“…Chaperones of the heat shock protein 70 (Hsp70) family engage in protein–protein interactions with many cochaperones. One “hotspot” for cochaperone binding is…”
Get full text

Luminescence complementation assay for measurement of binding to protein C-termini in live cells by Nadel, Cory M., Ran, Xu, Gestwicki, Jason E.

“…Protein-protein interactions (PPIs) involving the extreme C-terminus serve important scaffolding and regulatory functions. Here, we leveraged NanoBiT…”
Get full text

Voices of Fathers During Pregnancy: The MGH Prenatal Care Obstetrics Fatherhood Study Methods and Results by Kotelchuck, Milton, Levy, Raymond A., Nadel, Hiyam M.

“…Introduction Despite the growing recognition of father’s importance for early family health and well-being, there has been very limited attention to men’s own…”
Get full text

The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT) by Nadel, Cory M., Thwin, Aye C., Callahan, Matthew, Lee, Kanghyun, Connelly, Emily, Craik, Charles S., Southworth, Daniel R., Gestwicki, Jason E.

“…[Display omitted] •CHIP binds more tightly to phosphorylated tau (p-tau) than unmodified tau.•CHIP suppresses p-tau aggregation and rapidly ubiquitinates it in…”
Get full text

Socioeconomic variation in participation in colorectal cancer screening by McCaffery, K, Wardle, J, Nadel, M, Atkin, W

“…To investigate socioeconomic variation in participation in flexible sigmoidoscopy (FS) screening for colorectal cancer. A prospective study nested within a…”
Get more information

Comparison of Self-reported Fecal Occult Blood Testing with Automated Laboratory Records among Older Women in a Health Maintenance Organization by Mandelson, Margaret T., LaCroix, Andrea Z., Anderson, Lynda A., Nadel, Marion R., Lee, Nancy C.

“…Screening guidelines for colorectal cancer recommend annual fecal occult blood (FOB) testing for adults aged 50 years and older. Self-reported history of…”
Get full text

A Brief, Just-in-Time Sedation Training in the Pediatric Emergency Department Improves Performance During Adverse Events Encountered in Simulated Procedural Sedations by Schinasi, Dana Aronson, Colgan, Jennifer, Nadel, Frances M., Hales, Roberta L., Lorenz, Douglas, Donoghue, Aaron J.

“…Procedural sedation (PS) is commonly performed in emergency departments (EDs) by nonanesthesiologists. Although adverse events (AEs) are rare, providers must…”
Get full text

Mission possible: open innovation in nursing and patient care services at Massachusetts General Hospital by Nadel, Hiyam M, Al-Sultan, Nour, Berger, Alex, McCree, Paula, Banister, Gaurdia, Jung, Olivia

“…Although front-line nurses and staff are uniquely positioned to identify the inefficiencies and gaps in care delivery, formal processes are not always in place…”
Get more information

Sun Protection Behaviors of the U.S. White Population by Hall, H.Irene, May, Daniel S., Lew, Robert A., Koh, Howard K., Nadel, Marion

“…Background.Sun protection behaviors are recommended to prevent skin cancer, which has increased in incidence. This study measured the prevalence of sun…”
Get full text