Search Results - "Nadeau, D P"
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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7
Published in Journal of medicinal chemistry (07-06-2001)“…5-Dialkylaminosulfonylisatins have been identified as potent, nonpeptide inhibitors of caspases 3 and 7. The most active compound within this series (34)…”
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2
Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders
Published in Journal of bone and mineral research (01-03-1998)“…The decrease in bone volume associated with osteoporosis and age‐related osteopenia is accompanied by increased marrow adipose tissue formation. Reversal of…”
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3
Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents
Published in Cancer chemotherapy and pharmacology (01-05-2001)“…There is a need to find novel oestrogen receptor (ER) ligands that antagonize oestrogen action in the reproductive tissues and would therefore have therapeutic…”
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Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats
Published in Endocrinology (Philadelphia) (01-12-1998)“…Idoxifene, a novel selective estrogen receptor modulator, was tested for its effects on bone loss, serum cholesterol, and uterine wet weight and histology in…”
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5
Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
Published in Journal of orthopaedic research (01-05-2000)“…Apoptosis was induced in a human chondrocyte cell line, T/C 28a4, by treatment with various stimuli, including camptothecin, tumor necrosis factor-alpha,…”
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6
Role of caspases in human renal proximal tubular epithelial cell apoptosis
Published in European journal of pharmacology (21-12-2001)“…In the present study, we have used an in vitro model of apoptosis using primary human renal proximal tubular epithelial (RPTE) cells to investigate the…”
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7
Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells
Published in American Journal of Physiology: Cell Physiology (01-11-2000)“…Raloxifene and idoxifene are selective estrogen receptor modulators (SERMs) that exhibit tissue-specific agonist or antagonist properties via interactions with…”
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8
Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone
Published in Journal of cellular biochemistry (01-01-2000)“…Bipotential cells in human trabecular bone explant cultures that express osteoblast characteristics are able to undergo adipogenesis in the presence of…”
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9
Fascicle preservation surgery for facial nerve neuromas involving the posterior cranial fossa
Published in Otology & neurotology (01-03-2003)“…To assess facial nerve function after fascicle preservation surgery in cases of facial nerve neuroma involving the cerebellopontine angle. Retrospective case…”
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10
Anatomy of the thyroarytenoid branch of the recurrent laryngeal nerve
Published in Journal of voice (01-09-2004)“…To determine the position and anatomic variability of the thyroarytenoid (TA) branch of the recurrent laryngeal nerve (RLN). The RLN on 13 human cadaver…”
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