Search Results - "Nadeau, Brian"

Liver Toxicity with Cancer Checkpoint Inhibitor Therapy by Nadeau, Brian A, Fecher, Leslie A, Owens, Scott R, Razumilava, Nataliya

“…Immune checkpoint inhibition targeted against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) has shown…”
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Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review by Saeed, Naba, Nadeau, Brian, Shannon, Carol, Tincopa, Monica

“…Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease…”
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Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response by Flierl, Michael A, Rittirsch, Daniel, Nadeau, Brian A, Sarma, J Vidya, Day, Danielle E, Lentsch, Alex B, Huber-Lang, Markus S, Ward, Peter A

“…Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both…”
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Functional roles for C5a receptors in sepsis by Flierl, Michael A, Köhl, Jörg, Zetoune, Firas S, Rittirsch, Daniel, Nadeau, Brian A, Sarma, J Vidya, Huber-Lang, Markus, Ward, Peter A, Day, Danielle E, Mackay, Charles R, Gerard, Norma P, Cianflone, Katherine, Gerard, Craig

“…The function of the C5a receptors, C5ar (encoded by C5ar ) and C5l2 (encoded by Gpr77 ), especially of C5l2, which was originally termed a 'default receptor',…”
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Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values by Ducatman, Alan, Tan, Youran, Nadeau, Brian, Steenland, Kyle

“…Per- and polyfluoroalkyl substances (PFASs) including perfluorooctanoic acid (PFOA) are ubiquitous environmental contaminants. Prior analysis in the large "C8…”
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Phagocyte-derived catecholamines enhance acute inflammatory injury by FLIERL, Michael A, RITTIRSCH, Daniel, HONGWEI GAO, VAN ROOIJEN, Nico, HUBER-LANG, Markus S, NEUBIG, Richard R, WARD, Peter A, NADEAU, Brian A, CHEN, Anthony J, SARMA, J. Vidya, ZETOUNE, Firas S, MCGUIRE, Stephanie R, LIST, Rachel P, DAY, Danielle E, HOESEL, L. Marco

“…It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic…”
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Adverse functions of IL-17A in experimental sepsis by Flierl, Michael A, Rittirsch, Daniel, Gao, Hongwei, Hoesel, Laszlo M, Nadeau, Brian A, Day, Danielle E, Zetoune, Firas S, Sarma, J. Vidya, Huber-Lang, Markus S, Ferrara, James L.M, Ward, Peter A

“…IL-17A is a proinflammatory cytokine produced by a variety of cells. In the current study, we examined the role of IL-17A in sepsis induced in mice by cecal…”
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Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, McGuire, Stephanie R, Hoesel, Laszlo M, Ipaktchi, Kyros, Zetoune, Firas S, Sarma, J. Vidya, Leng, Lin, Huber-Lang, Markus S, Neff, Thomas A, Bucala, Richard, Ward, Peter A

“…Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known…”
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The gut microbiome and nonalcoholic fatty liver disease by Nadeau, Brian A., Conjeevaram, Hari

“…Watch a video presentation of this article…”
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Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system by Rittirsch, Daniel, Flierl, Michael A, Nadeau, Brian A, Day, Danielle E, Huber-Lang, Markus S, Grailer, Jamison J, Zetoune, Firas S, Andjelkovic, Anuska V, Fasano, Alessio, Ward, Peter A

“…Zonulin is a protein involved in the regulation of tight junctions (TJ) in epithelial or endothelial cells. Zonulin is known to affect TJ in gut epithelial…”
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Functions of the complement components C3 and C5 during sepsis by Flierl, Michael A, Rittirsch, Daniel, Nadeau, Brian A, Day, Danielle E, Zetoune, Firas S, Sarma, J. Vidya, Huber-Lang, Markus S, Ward, Peter A

“…Activation of the complement system is a key event in the pathogenesis of sepsis. Nevertheless, the exact mechanisms remain inadequately understood. In the…”
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The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis by Flierl, Michael A, Rittirsch, Daniel, Chen, Anthony J, Nadeau, Brian A, Day, Danielle E, Sarma, J Vidya, Huber-Lang, Markus S, Ward, Peter A

“…Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the…”
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Cross-Talk between TLR4 and FcγReceptorIII (CD16) Pathways by Rittirsch, Daniel, Flier, Michael A, Day, Danielle E, Nadeau, Brian A, Zetoune, Firas S, Sarma, J. Vidya, Werner, Clement M, Wanner, Guido A, Simmen, Hans-Peter, Huber- Lang, Markus S, Ward, Peter A

“…Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs)…”
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Mo1493 EVALUATION OF DIETARY APPROACHES FOR THE TREATMENT OF NONALCOHOLIC FATTY LIVER DISEASE: A SYSTEMATIC REVIEW by Saeed, Naba, Nadeau, Brian, Shannon, Carol, Tincopa, Monica A.

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Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, Zetoune, Firas S, Sarma, J Vidya, Werner, Clement M, Wanner, Guido A, Simmen, Hans-Peter, Huber-Lang, Markus S, Ward, Peter A

“…Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs)…”
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Leptospirosis: A Rare Cause of Hyperbilirubinemia and Acute Kidney Injury in a Non-endemic Area by Kozyk, Marko, Strubchevska, Kateryna, Nadeau, Brian

“…Leptospirosis is a zoonosis with clinical manifestations caused by a pathogenic bacterium of the genus Leptospira. A high index of suspicion is required to…”
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Role of zonulin as prehaptoglobin2 in acute lung injury by Rittirsch, Daniel, Flierl, Michael A., Day, Danielle E., Nadeau, Brian A., Werner, Clement M. L., Wanner, Guido A., Simmen, Hans‐Peter, Fasano, Alessio, Ward, Peter A.

“…Zonulin is a regulator of intercellular tight junctions. However, only little is known about its role in regulating extraintestinal epithelial barriers,…”
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Functional Roles for C5a Receptors in Sepsis by Rittirsch, Daniel, Sarma, J. Vidya, Day, Danielle E., Nadeau, Brian A., Zetoune, Firas S., Chen, Anthony J., Huber‐Lang, Markus S., Flierl, Michael A., Ward, Peter A.

“…Abstract only The complement anaphylatoxin, C5a, is excessively generated during sepsis and plays adverse roles in survival. The function of the two C5a…”
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Cross-Talk between TLR4 and Fc[gamma]ReceptorIII (CD16) Pathways: e1000464 by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, Zetoune, Firas S, Sarma, J Vidya, Werner, Clement M, Wanner, Guido A, Simmen, Hans-Peter, Huber-Lang, Markus S, Ward, Peter A

“…Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs)…”
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Cross-Talk between TLR4 and FcI3ReceptorIII (CD16) Pathways by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, Zetoune, Firas S, Sarma, JVidya, Werner, Clement M, Wanner, Guido A, Simmen, Hans-Peter, Huber-Lang, Markus S, Ward, Peter A, Douek, Danny C

“…Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs)…”
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