Search Results - "Nadaradjane, Arulraj"

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma by Rabé, Marion, Dumont, Solenne, Álvarez-Arenas, Arturo, Janati, Hicham, Belmonte-Beitia, Juan, Calvo, Gabriel F., Thibault-Carpentier, Christelle, Séry, Quentin, Chauvin, Cynthia, Joalland, Noémie, Briand, Floriane, Blandin, Stéphanie, Scotet, Emmanuel, Pecqueur, Claire, Clairambault, Jean, Oliver, Lisa, Perez-Garcia, Victor, Nadaradjane, Arulraj, Cartron, Pierre-François, Gratas, Catherine, Vallette, François M.

“…Drug resistance limits the therapeutic efficacy in cancers and leads to tumor recurrence through ill-defined mechanisms. Glioblastoma (GBM) are the deadliest…”
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Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells by Guyon, Nina, Garnier, Delphine, Briand, Joséphine, Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Raimbourg, Judith, Campone, Mario, Heymann, Dominique, Vallette, François M., Frenel, Jean-Sébastien, Cartron, Pierre-François

“…Anti-PD1 immunotherapy, as a single agent or in combination with standard chemotherapies, has significantly improved the outcome of many patients with cancers…”
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Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner by Duforestel, Manon, Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Briand, Joséphine, Olivier, Christophe, Frenel, Jean-Sébastien, Vallette, François M., Lelièvre, Sophie A., Cartron, Pierre-François

“…The acknowledgment that pollutants might influence the epigenome raises serious concerns regarding their long-term impact on the development of chronic…”
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Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme by Cheray, Mathilde, Etcheverry, Amandine, Jacques, Camille, Pacaud, Romain, Bougras-Cartron, Gwenola, Aubry, Marc, Denoual, Florent, Peterlongo, Pierre, Nadaradjane, Arulraj, Briand, Joséphine, Akcha, Farida, Heymann, Dominique, Vallette, François M, Mosser, Jean, Ory, Benjamin, Cartron, Pierre-François

“…Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine…”
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Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression by Bougras-Cartron, Gwenola, Nadaradjane, Arulraj, Joalland, Marie-Pierre, Lalier-Bretaudeau, Lisenn, Raimbourg, Judith, Cartron, Pierre-François

“…Despite encouraging anti-tumour activity in lung cancer, anti-PD-1 therapy has encountered increasing resistance to treatment. Several companion diagnostic…”
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N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool by Briand, Joséphine, Sérandour, Aurélien A., Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Heymann, Dominique, Ory, Benjamin, Vallette, François M., Cartron, Pierre-François

“…MicroRNAs (miRNAs or miRs) play crucial roles in biological and pathological processes. Some miRNAs also appear as promising biomarkers and therapeutic tools…”
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miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker by Nadaradjane, Arulraj, Briand, Joséphine, Bougras-Cartron, Gwenola, Disdero, Valentine, Vallette, François M., Frenel, Jean-Sébastien, Cartron, Pierre-François

“…In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1)…”
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Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth by Cheray, Mathilde, Pacaud, Romain, Nadaradjane, Arulraj, Oliver, Lisa, Vallette, François M, Cartron, Pierre-François

“…DNA methylation is a fundamental feature of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantage. Thus,…”
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Diuron modulates the DNA methylation status of the ILT7 and TRAIL/TNFSF10 genes and decreases the killing activity of plasmacytoid dendritic cells by Briand, Joséphine, Joalland, Marie-Pierre, Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Olivier, Christophe, Vallette, François M., Perruche, Sylvain, Cartron, Pierre-François

“…Background Plasmacytoid dendritic cell (pDC) is described as the Swiss knife of immune system. Thus, the understanding of aberrant epigenetic reprogramming of…”
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Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle by Hervouet, Eric, Nadaradjane, Arulraj, Gueguen, Marine, Vallette, François M, Cartron, Pierre-François

“…The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process…”
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Abstract P4-04-09: The acquired resistance of mammary cancer cells to CDK4/6 inhibitors drives a DNA methylation reprogramming of genes encoding for BCL2 family members that confers a phenotype of high apopto-sensitivity induced by a BH3-mimetic drug by FRENEL, Jean-Sebastien, Voisin, Deborah, Nadaradjane, Arulraj, Bougras-Catron, Gwenola, Campone, Mario, Serandour, Aurelien, Cartron, Pierre-Francois

“…Abstract Introduction. Due to the aberrant deregulation of the CDK4/6-INK4-RB pathway in breast cancer, CDK4/6 inhibitors are now a cornerstone of first line…”
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PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma by Asgarova, A., Asgarov, K., Godet, Y., Peixoto, P., Nadaradjane, A., Boyer-Guittaut, M., Galaine, J., Guenat, D., Mougey, V., Perrard, J., Pallandre, J. R., Bouard, A., Balland, J., Tirole, C., Adotevi, O., Hendrick, E., Herfs, M., Cartron, P. F., Borg, C., Hervouet, E.

“…Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased capacities of proliferation, invasion and have the ability to generate…”
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Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity by Briand, Joséphine, Garnier, Delphine, Nadaradjane, Arulraj, Clément-Colmou, Karen, Potiron, Vincent, Supiot, Stéphane, Bougras-Cartron, Gwenola, Frenel, Jean-Sébastien, Heymann, Dominique, Vallette, François M, Cartron, Pierre-François

“…We here hypothesized that tumor-derived exosomal miRNA (TexomiR) released from irradiated tumors may play a role in the tumor cells escape to natural killer…”
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5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease by Pertuit, David, Moulari, Brice, Betz, Thomas, Nadaradjane, Arulraj, Neumann, Dirk, Ismaïli, Lhassane, Refouvelet, Bernard, Pellequer, Yann, Lamprecht, Alf

“…Nanoparticles (NP) are known for their specific accumulation in the inflamed tissues in the colon and may therefore allow a selective delivery to the site of…”
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Histone H3 phosphorylation in GBM: a new rational to guide the use of kinase inhibitors in anti-GBM therapy by Pacaud, Romain, Cheray, Mathilde, Nadaradjane, Arulraj, Vallette, François M, Cartron, Pierre-François

“…Histones post-translational modifications (PTMs) are crucial components of diverse processes that modulate chromatin. Among the histones PTMs, the histones…”
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Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation by Briand, Joséphine, Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Olivier, Christophe, Vallette, François M, Cartron, Pierre-François

“…Diuron is an environmental component listed as a likely human carcinogen. Several other studies report that diuron can be oncogenic for bladder, urothelial,…”
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Identification of TET1 Partners That Control Its DNA-Demethylating Function by Cartron, Pierre-François, Nadaradjane, Arulraj, Lepape, Fiona, Lalier, Lisenn, Gardie, Betty, Vallette, François M

“…Several recent reports have identified TET1 as the main enzyme modulating DNA methylation and gene transcription via hydroxylation of 5-methylcytosine…”
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Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4- c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4- c]quinoline-5-ones obtained by Biginelli reaction in two steps by Ismaili, Lhassane, Nadaradjane, Arulraj, Nicod, Laurence, Guyon, Catherine, Xicluna, Alain, Robert, Jean-François, Refouvelet, Bernard

“…New hexahydropyrimido[5,4- c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4- c]quinoline-5-ones were prepared in two steps from ethyl…”
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Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness by Cheray, Mathilde, Nadaradjane, Arulraj, Bonnet, Pascal, Routier, Sylvain, Vallette, François M, Cartron, Pierre-François

“…DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic…”
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Specific inhibition of one DNMT1-including complex influences tumor initiation and progression by Cheray, Mathilde, Pacaud, Romain, Nadaradjane, Arulraj, Vallette, François M, Cartron, Pierre-François

“…Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also…”
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