Search Results - "Nadal Desbarats, Lydie"
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Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein
Published in The EMBO journal (14-06-2022)“…Influenza virus infection causes considerable morbidity and mortality, but current therapies have limited efficacy. We hypothesized that investigating the…”
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Wildtype motoneurons, ALS‐Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling
Published in Glia (01-04-2017)“…The selective degeneration of motoneuron that typifies amyotrophic lateral sclerosis (ALS) implicates non‐cell‐autonomous effects of astrocytes. However,…”
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3
Nutrient sources differ in the fertilised eggs of two divergent broiler lines selected for meat ultimate pH
Published in Scientific reports (01-04-2022)“…The pHu+ and pHu− lines, which were selected based on the ultimate pH (pHu) of the breast muscle, represent a unique model to study the genetic and…”
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Extensive exploration of a novel rat model of Parkinson's disease using partial 6‐hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches
Published in Synapse (New York, N.Y.) (01-03-2019)“…Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons constituting the nigrostriatal pathway. Neuroinflammation, related…”
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Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities
Published in Acta Physiologica (01-03-2020)“…Aim Tieg1 is involved in multiple signalling pathways, human diseases, and is highly expressed in muscle where its functions are poorly understood. Methods We…”
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SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes
Published in Translational psychiatry (22-04-2021)“…Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorder characterized by inattention, impulsivity, and…”
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Temporal metabolomics state in pregnant rat: Analysis of amniotic fluid, placenta, and maternal plasma at embryonic and fetal time points
Published in Placenta (Eastbourne) (01-05-2024)“…During pregnancy, the dynamic metabolic demands for fetal growth require a continuous supply of essential metabolites. Understanding maternal metabolome…”
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Optimization of Sample Preparation for Metabolomics Exploration of Urine, Feces, Blood and Saliva in Humans Using Combined NMR and UHPLC-HRMS Platforms
Published in Molecules (Basel, Switzerland) (06-07-2021)“…Currently, most clinical studies in metabolomics only consider a single type of sample such as urine, plasma, or feces and use a single analytical platform,…”
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Serum and Muscle Metabolomics for the Prediction of Ultimate pH, a Key Factor for Chicken-Meat Quality
Published in Journal of proteome research (01-04-2016)“…Variations in muscle glycogen storage are highly correlated with variations in meat ultimate pH (pHu), a key factor for poultry meat quality. A total of two…”
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Endothelial Cells, First Target of Drug Delivery Using Microbubble-Assisted Ultrasound
Published in Ultrasound in medicine & biology (01-07-2020)“…Microbubble-assisted ultrasound has emerged as a promising method for local drug delivery. Microbubbles are intravenously injected and locally activated by…”
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Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology
Published in Journal of proteome research (04-12-2015)“…Autism spectrum disorder (ASD) is a neurodevelopmental disorder with no clinical biomarker. The aims of this study were to characterize a metabolic signature…”
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Differential MRI diagnosis between brain abscesses and necrotic or cystic brain tumors using the apparent diffusion coefficient and normalized diffusion-weighted images
Published in Magnetic resonance imaging (01-07-2003)“…Magnetic Resonance Diffusion-Weighted Imaging (DWI) has been reported to be helpful for the differential diagnosis between abscesses and cystic/necrotic brain…”
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Allantoic fluid metabolome reveals specific metabolic signatures in chicken lines different for their muscle glycogen content
Published in Scientific reports (31-05-2023)“…Nutrient availability in eggs can affect early metabolic orientation in birds. In chickens divergently selected on the Pectoralis major ultimate pH, a proxy…”
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GC-MS-based urine metabolic profiling of autism spectrum disorders
Published in Analytical and bioanalytical chemistry (01-06-2013)“…Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders resulting from multiple factors. Diagnosis is based on behavioural and…”
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First Metabolomic Signature of Blood-Brain Barrier Opening Induced by Microbubble-Assisted Ultrasound
Published in Frontiers in molecular neuroscience (20-06-2022)“…Microbubble (MB)-assisted ultrasound (US) is a promising physical method to increase non-invasively, transiently, and precisely the permeability of the…”
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DESI-TQ-MS imaging for ex vivo brain biodistribution assessment: evaluation of LBT-999, a ligand of the dopamine transporter (DAT)
Published in EJNMMI radiopharmacy and chemistry (27-08-2024)“…Background Selection of the most promising radiotracer candidates for radiolabeling is a difficult step in the development of radiotracer pharmaceuticals,…”
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Elucidating time-dependent changes in the urinary metabolome of renal transplant patients by a combined (1)H NMR and GC-MS approach
Published in Molecular bioSystems (01-09-2015)“…Urine metabolomic profiling can identify biochemical alterations resulting from various injuries affecting the graft outcome after renal transplantation. Here,…”
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Serum and Soleus Metabolomics Signature of Klf10 Knockout Mice to Identify Potential Biomarkers
Published in Metabolites (01-06-2022)“…The transcription factor Krüppel-like factor 10 (Klf10), also known as Tieg1 for TGFβ (Inducible Early Gene-1) is known to control numerous genes in many cell…”
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Analytical Methodology for a Metabolome Atlas of Goat’s Plasma, Milk and Feces Using 1H-NMR and UHPLC-HRMS
Published in Metabolites (04-10-2021)“…Metabolomics has been increasingly used in animal and food sciences. Animal health is one of the most important factor that can also alter animal integrity and…”
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1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis
Published in PloS one (08-10-2010)“…Pathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful in routine patient…”
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