Blind randomized controlled study of the efficacy of cognitive training in Parkinson's disease

The aim of this study was to analyze the efficacy of a cognitive training program on cognitive performance and quality of life in nondemented Parkinson's disease patients. Participants who met UK Brain Bank diagnosis criteria for Parkinson's disease, with I–III Hoehn & Yahr, aged 50–80...

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Bibliographic Details
Published in:	Movement disorders Vol. 26; no. 7; pp. 1251 - 1258
Main Authors:	París, Anna Prats, Saleta, Heidi Guerra, de la Cruz Crespo Maraver, Maria, Silvestre, Emmanuel, Freixa, Maite Garolera, Torrellas, Cristina Petit, Pont, Silvia Alonso, Nadal, Marc Fabra, Garcia, Sheila Alcaine, Bartolomé, Maria Victoria Perea, Fernández, Valentina Ladera, Bayés, Àngels Rusiñol
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-06-2011 Wiley
Subjects:	Aged Aged, 80 and over Biological and medical sciences cognition Cognition Disorders - psychology Cognition Disorders - therapy cognitive impairment Cognitive Therapy - methods cognitive training neuropsychology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Middle Aged Neurology Neuropsychological Tests Parkinson Disease - psychology Parkinson Disease - therapy Parkinson's disease Quality of Life Treatment Outcome Nervous system diseases Cognitive disorder Parkinson's disease Central nervous system disease Parkinson disease Degenerative disease Cognition cognitive impairment cognitive training neuropsychology Cerebral disorder Extrapyramidal syndrome
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Summary:	The aim of this study was to analyze the efficacy of a cognitive training program on cognitive performance and quality of life in nondemented Parkinson's disease patients. Participants who met UK Brain Bank diagnosis criteria for Parkinson's disease, with I–III Hoehn & Yahr, aged 50–80, and nondemented (Mini‐Mental State Examination ≥ 23) were recruited. Patient's cognitive performance and functional and quality‐of‐life measures were assessed with standardized neuropsychological tests and scales at baseline and after 4 weeks. Subjects were randomly and blindly allocated by age and premorbid intelligence (Vocabulary, Wechsler Adult Intelligence Scale‐III) into 2 groups: an experimental group and a control group. The experimental group received 4 weeks of 3 weekly 45‐minute sessions using multimedia software and paper‐and‐pencil cognitive exercises, and the control group received speech therapy. A total of 28 patients were analyzed. Compared with the control group participants (n = 12), the experimental group participants (n = 16) demonstrated improved performance in tests of attention, information processing speed, memory, visuospatial and visuoconstructive abilities, semantic verbal fluency, and executive functions. There were no observable benefits in self‐reported quality of life or cognitive difficulties in activities of daily living. We concluded that intensive cognitive training may be a useful tool in the management of cognitive functions in Parkinson's disease. © 2011 Movement Disorder Society
Bibliography:	Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article. ark:/67375/WNG-MD6ZZ77Z-T istex:AE0DC339F1E7D1CFB2204EA3E5C6D381B183ADEF ArticleID:MDS23688 Author Roles and Disclosures Full financial disclosures and author roles may be found in the online version of this article. Relevant conflicts of interest/financial disclosures: Nothing to report. Anna Prats París and Heidi Guerra Saleta contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-News-1 ObjectType-Feature-3
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.23688