Search Results - "Nadaf, Naeem M"

A single-cell map of antisense oligonucleotide activity in the brain by Mortberg, Meredith A, Gentile, Juliana E, Nadaf, Naeem M, Vanderburg, Charles, Simmons, Sean, Dubinsky, Dan, Slamin, Adam, Maldonado, Salome, Petersen, Caroline L, Jones, Nichole, Kordasiewicz, Holly B, Zhao, Hien T, Vallabh, Sonia M, Minikel, Eric Vallabh

“…Abstract Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly throughout the central nervous system (CNS). By modulating…”
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Spatial genomics enables multi-modal study of clonal heterogeneity in tissues by Zhao, Tongtong, Chiang, Zachary D., Morriss, Julia W., LaFave, Lindsay M., Murray, Evan M., Del Priore, Isabella, Meli, Kevin, Lareau, Caleb A., Nadaf, Naeem M., Li, Jilong, Earl, Andrew S., Macosko, Evan Z., Jacks, Tyler, Buenrostro, Jason D., Chen, Fei

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Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease by Kamath, Tushar, Abdulraouf, Abdulraouf, Burris, S. J., Langlieb, Jonah, Gazestani, Vahid, Nadaf, Naeem M., Balderrama, Karol, Vanderburg, Charles, Macosko, Evan Z.

“…The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson’s disease (PD)…”
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Spatial genomics enables multi-modal study of clonal heterogeneity in tissues by Zhao, Tongtong, Chiang, Zachary D., Morriss, Julia W., LaFave, Lindsay M., Murray, Evan M., Del Priore, Isabella, Meli, Kevin, Lareau, Caleb A., Nadaf, Naeem M., Li, Jilong, Earl, Andrew S., Macosko, Evan Z., Jacks, Tyler, Buenrostro, Jason D., Chen, Fei

“…The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying…”
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The molecular cytoarchitecture of the adult mouse brain by Langlieb, Jonah, Sachdev, Nina S., Balderrama, Karol S., Nadaf, Naeem M., Raj, Mukund, Murray, Evan, Webber, James T., Vanderburg, Charles, Gazestani, Vahid, Tward, Daniel, Mezias, Chris, Li, Xu, Flowers, Katelyn, Cable, Dylan M., Norton, Tabitha, Mitra, Partha, Chen, Fei, Macosko, Evan Z.

“…The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of…”
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Slide-tags enables single-nucleus barcoding for multimodal spatial genomics by Russell, Andrew J. C., Weir, Jackson A., Nadaf, Naeem M., Shabet, Matthew, Kumar, Vipin, Kambhampati, Sandeep, Raichur, Ruth, Marrero, Giovanni J., Liu, Sophia, Balderrama, Karol S., Vanderburg, Charles R., Shanmugam, Vignesh, Tian, Luyi, Iorgulescu, J. Bryan, Yoon, Charles H., Wu, Catherine J., Macosko, Evan Z., Chen, Fei

“…Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells,…”
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Early Alzheimer’s disease pathology in human cortex involves transient cell states by Gazestani, Vahid, Kamath, Tushar, Nadaf, Naeem M., Dougalis, Antonios, Burris, S.J., Rooney, Brendan, Junkkari, Antti, Vanderburg, Charles, Pelkonen, Anssi, Gomez-Budia, Mireia, Välimäki, Nelli-Noora, Rauramaa, Tuomas, Therrien, Martine, Koivisto, Anne M., Tegtmeyer, Matthew, Herukka, Sanna-Kaisa, Abdulraouf, Abdulraouf, Marsh, Samuel E., Hiltunen, Mikko, Nehme, Ralda, Malm, Tarja, Stevens, Beth, Leinonen, Ville, Macosko, Evan Z.

“…Cellular perturbations underlying Alzheimer’s disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a…”
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Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties by Osorno, Tomas, Rudolph, Stephanie, Nguyen, Tri, Kozareva, Velina, Nadaf, Naeem M., Norton, Aliya, Macosko, Evan Z., Lee, Wei-Chung Allen, Regehr, Wade G.

“…To understand how the cerebellar cortex transforms mossy fiber (MF) inputs into Purkinje cell (PC) outputs, it is vital to delineate the elements of this…”
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A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain by Chen, Christopher H., Newman, Leannah N., Stark, Amanda P., Bond, Katherine E., Zhang, Dawei, Nardone, Stefano, Vanderburg, Charles R., Nadaf, Naeem M., Yao, Zhiyi, Mutume, Kefiloe, Flaquer, Isabella, Lowell, Bradford B., Macosko, Evan Z., Regehr, Wade G.

“…In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar…”
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Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration by Hochbaum, Daniel R, Hulshof, Lauren, Urke, Amanda, Wang, Wengang, Dubinsky, Alexandra C, Farnsworth, Hannah C, Hakim, Richard, Lin, Sherry, Kleinberg, Giona, Robertson, Keiramarie, Park, Canaria, Solberg, Alyssa, Yang, Yechan, Baynard, Caroline, Nadaf, Naeem M, Beron, Celia C, Girasole, Allison E, Chantranupong, Lynne, Cortopassi, Marissa D, Prouty, Shannon, Geistlinger, Ludwig, Banks, Alexander S, Scanlan, Thomas S, Datta, Sandeep Robert, Greenberg, Michael E, Boulting, Gabriella L, Macosko, Evan Z, Sabatini, Bernardo L

“…Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must…”
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Publisher Correction: Slide-tags enables single-nucleus barcoding for multimodal spatial genomics by Russell, Andrew J. C., Weir, Jackson A., Nadaf, Naeem M., Shabet, Matthew, Kumar, Vipin, Kambhampati, Sandeep, Raichur, Ruth, Marrero, Giovanni J., Liu, Sophia, Balderrama, Karol S., Vanderburg, Charles R., Shanmugam, Vignesh, Tian, Luyi, Iorgulescu, J. Bryan, Yoon, Charles H., Wu, Catherine J., Macosko, Evan Z., Chen, Fei

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A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex by Yao, Zizhen, Liu, Hanqing, Xie, Fangming, Fischer, Stephan, Adkins, Ricky S., Aldridge, Andrew I., Ament, Seth A., Bartlett, Anna, Behrens, M. Margarita, Van den Berge, Koen, Bertagnolli, Darren, de Bézieux, Hector Roux, Biancalani, Tommaso, Booeshaghi, A. Sina, Bravo, Héctor Corrada, Casper, Tamara, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather, Crichton, Kirsten, Crow, Megan, Dee, Nick, Dougherty, Elizabeth L., Doyle, Wayne I., Dudoit, Sandrine, Fang, Rongxin, Felix, Victor, Fong, Olivia, Giglio, Michelle, Goldy, Jeff, Hawrylycz, Mike, Herb, Brian R., Hertzano, Ronna, Hou, Xiaomeng, Hu, Qiwen, Kancherla, Jayaram, Kroll, Matthew, Lathia, Kanan, Li, Yang Eric, Lucero, Jacinta D., Luo, Chongyuan, Mahurkar, Anup, McMillen, Delissa, Nadaf, Naeem M., Nery, Joseph R., Nguyen, Thuc Nghi, Niu, Sheng-Yong, Ntranos, Vasilis, Orvis, Joshua, Osteen, Julia K., Pham, Thanh, Pinto-Duarte, Antonio, Poirion, Olivier, Preissl, Sebastian, Purdom, Elizabeth, Rimorin, Christine, Risso, Davide, Rivkin, Angeline C., Smith, Kimberly, Street, Kelly, Sulc, Josef, Svensson, Valentine, Tieu, Michael, Torkelson, Amy, Tung, Herman, Vaishnav, Eeshit Dhaval, Vanderburg, Charles R., van Velthoven, Cindy, Wang, Xinxin, White, Owen R., Huang, Z. Josh, Kharchenko, Peter V., Pachter, Lior, Ngai, John, Regev, Aviv, Tasic, Bosiljka, Welch, Joshua D., Gillis, Jesse, Macosko, Evan Z., Ren, Bing, Ecker, Joseph R., Zeng, Hongkui, Mukamel, Eran A.

“…Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain 1 – 3 . With the…”
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