Search Results - "Naciff, Jorge"
-
1
Use of connectivity mapping to support read across: A deeper dive using data from 186 chemicals, 19 cell lines and 2 case studies
Published in Toxicology (Amsterdam) (01-07-2019)“…We previously demonstrated that the Connectivity Map (CMap) (Lamb et al., 2006) concept can be successfully applied to a predictive toxicology paradigm to…”
Get full text
Journal Article -
2
Toward Good Read-Across Practice (GRAP) guidance
Published in ALTEX, alternatives to animal experimentation (2016)“…Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety…”
Get full text
Journal Article -
3
Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping
Published in Toxicological sciences (01-06-2016)“…Connectivity mapping is a method used in the pharmaceutical industry to find connections between small molecules, disease states, and genes. The concept can be…”
Get full text
Journal Article -
4
Incorporation of in vitro techniques for botanicals dietary supplement safety assessment – Towards evaluation of developmental and reproductive toxicity (DART)
Published in Food and chemical toxicology (01-10-2020)“…As complex mixtures, botanicals present unique challenges when assessing safe use, particularly when endpoint gaps exist that cannot be fully resolved by…”
Get full text
Journal Article -
5
Article title: Transcriptional profiling efficacy to define biological activity similarity for cosmetic ingredients' safety assessment based on next-generation read-across
Published in Frontiers in toxicology (21-12-2022)“…The objective of this work was to use transcriptional profiling to assess the biological activity of structurally related chemicals to define their biological…”
Get full text
Journal Article -
6
In Response: Ecotoxicogenomics addressing future needs: An industry perspective
Published in Environmental toxicology and chemistry (01-04-2015)Get full text
Journal Article -
7
A strategy for safety assessment of chemicals with data gaps for developmental and/or reproductive toxicity
Published in Regulatory toxicology and pharmacology (01-07-2015)“…•For most chemicals DART NOAELs are similar to or higher than chronic repeat dose NOAELs.•The existing database for chemicals more frequently includes repeat…”
Get full text
Journal Article -
8
Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across
Published in Current research in toxicology (01-01-2023)“…[Display omitted] •More than 1100 chemicals were evaluated in order to construct a decision tree, and included chemicals that are directly reactive, that…”
Get full text
Journal Article -
9
Dose- and Time-Dependent Transcriptional Response of Ishikawa Cells Exposed to Genistein
Published in Toxicological sciences (01-05-2016)“…To further define the utility of the Ishikawa cells as a reliable in vitro model to determine the potential estrogenic activity of chemicals of interest,…”
Get full text
Journal Article -
10
Identification of Putative Gene-Based Markers of Renal Toxicity
Published in Environmental health perspectives (01-03-2004)“…This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined…”
Get full text
Journal Article -
11
A novel transcriptomics based in vitro method to compare and predict hepatotoxicity based on mode of action
Published in Toxicology (Amsterdam) (03-02-2015)“…Abstract High-content data have the potential to inform mechanism of action for toxicants. However, most data to support this notion have been generated in…”
Get full text
Journal Article -
12
Case studies to test: A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments
Published in Regulatory toxicology and pharmacology (01-06-2011)“…A process for evaluating analogs for use in SAR (Structure–Activity Relationship) assessments was previously published ( Wu et al. 2010). Subsequently, this…”
Get full text
Journal Article -
13
The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent
Published in Toxicology (Amsterdam) (11-04-2010)“…Abstract A reliable in vitro model to determine the potential estrogenic activity of chemicals of interest is still unavailable. To further investigate the…”
Get full text
Journal Article -
14
Predicting developmental toxicity through toxicogenomics
Published in Birth defects research. Part C. Embryo today (01-06-2010)“…Global analysis of gene expression in target cells or tissues in response to a toxicant holds significant promise for predictive toxicology. Toxicants elicit a…”
Get full text
Journal Article -
15
Effects of Transplacental 17-α-Ethynyl Estradiol or Bisphenol A on the Developmental Profile of Steroidogenic Acute Regulatory Protein in the Rat Testis
Published in Birth defects research. Part B. Developmental and reproductive toxicology (01-08-2012)“…Previous research from our laboratory has determined the transcript profiles for developing fetal rat female and male reproductive tracts following…”
Get full text
Journal Article -
16
Gene Expression Changes Induced in the Testis by Transplacental Exposure to High and Low Doses of 17α-Ethynyl Estradiol, Genistein, or Bisphenol A
Published in Toxicological sciences (01-08-2005)“…The purpose of this study was to determine (1) the transcriptional program elicited by exposure to three estrogen receptor (ER) agonists: 17 α-ethynyl…”
Get full text
Journal Article -
17
Gene Expression Profile Induced by 17α-Ethynyl Estradiol, Bisphenol A, and Genistein in the Developing Female Reproductive System of the Rat
Published in Toxicological sciences (01-07-2002)“…Exposure to some compounds with estrogenic activity, during fetal development, has been shown to alter development of reproductive organs, leading to abnormal…”
Get full text
Journal Article -
18
Toxicogenomic Approach to Endocrine Disrupters: Identification of a Transcript Profile Characteristic of Chemicals with Estrogenic Activity
Published in Toxicologic pathology (01-07-2004)“…Public concerns have been raised in recent years over the possible adverse effects that may result from exposure to chemicals in the environment that have the…”
Get full text
Journal Article -
19
Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity
Published in Environmental health perspectives (01-03-2004)“…Within the International Life Sciences Institute Committee on Genomics, a working group was formed to focus on the application of microarray technology to…”
Get full text
Journal Article -
20
Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment
Published in Environmental health perspectives (01-03-2004)“…Microarrays allow for the simultaneous measurement of changes in the levels of thousands of messenger RNAs within a single experiment. As such, the potential…”
Get full text
Journal Article