Search Results - "Naciff, Jorge"

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    Use of connectivity mapping to support read across: A deeper dive using data from 186 chemicals, 19 cell lines and 2 case studies by De Abrew, K. Nadira, Shan, Yuqing K., Wang, Xiaohong, Krailler, Jesse M., Kainkaryam, Raghunandan M., Lester, Cathy C., Settivari, Raja S., LeBaron, Matthew J., Naciff, Jorge M., Daston, George P.

    Published in Toxicology (Amsterdam) (01-07-2019)
    “…We previously demonstrated that the Connectivity Map (CMap) (Lamb et al., 2006) concept can be successfully applied to a predictive toxicology paradigm to…”
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    Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping by De Abrew, K Nadira, Kainkaryam, Raghunandan M, Shan, Yuqing K, Overmann, Gary J, Settivari, Raja S, Wang, Xiaohong, Xu, Jun, Adams, Rachel L, Tiesman, Jay P, Carney, Edward W, Naciff, Jorge M, Daston, George P

    Published in Toxicological sciences (01-06-2016)
    “…Connectivity mapping is a method used in the pharmaceutical industry to find connections between small molecules, disease states, and genes. The concept can be…”
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    Incorporation of in vitro techniques for botanicals dietary supplement safety assessment – Towards evaluation of developmental and reproductive toxicity (DART) by VanderMolen, Karen M., Naciff, Jorge M., Kennedy, Kevin, Otto-Bruc, Annie, Shan, Yuqing, Wang, Xiaohong, Daston, George P., Mahony, Catherine

    Published in Food and chemical toxicology (01-10-2020)
    “…As complex mixtures, botanicals present unique challenges when assessing safe use, particularly when endpoint gaps exist that cannot be fully resolved by…”
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    Article title: Transcriptional profiling efficacy to define biological activity similarity for cosmetic ingredients' safety assessment based on next-generation read-across by Naciff, Jorge M, Shan, Yuquing K, Wang, Xiaohong, Daston, George P

    Published in Frontiers in toxicology (21-12-2022)
    “…The objective of this work was to use transcriptional profiling to assess the biological activity of structurally related chemicals to define their biological…”
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    A strategy for safety assessment of chemicals with data gaps for developmental and/or reproductive toxicity by Blackburn, Karen, Daston, George, Fisher, Joan, Lester, Cathy, Naciff, Jorge M., Rufer, Echoleah S., Stuard, Sharon B., Woeller, Kara

    Published in Regulatory toxicology and pharmacology (01-07-2015)
    “…•For most chemicals DART NOAELs are similar to or higher than chronic repeat dose NOAELs.•The existing database for chemicals more frequently includes repeat…”
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    Dose- and Time-Dependent Transcriptional Response of Ishikawa Cells Exposed to Genistein by Naciff, Jorge M, Khambatta, Zubin S, Carr, Gregory J, Tiesman, Jay P, Singleton, David W, Khan, Sohaib A, Daston, George P

    Published in Toxicological sciences (01-05-2016)
    “…To further define the utility of the Ishikawa cells as a reliable in vitro model to determine the potential estrogenic activity of chemicals of interest,…”
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    A novel transcriptomics based in vitro method to compare and predict hepatotoxicity based on mode of action by De Abrew, K. Nadira, Overmann, Gary J, Adams, Rachel L, Tiesman, Jay P, Dunavent, John, Shan, Yuqing K, Carr, Gregory J, Daston, George P, Naciff, Jorge M

    Published in Toxicology (Amsterdam) (03-02-2015)
    “…Abstract High-content data have the potential to inform mechanism of action for toxicants. However, most data to support this notion have been generated in…”
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    The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent by Naciff, Jorge M, Khambatta, Zubin S, Reichling, Timothy D, Carr, Gregory J, Tiesman, Jay P, Singleton, David W, Khan, Sohaib A, Daston, George P

    Published in Toxicology (Amsterdam) (11-04-2010)
    “…Abstract A reliable in vitro model to determine the potential estrogenic activity of chemicals of interest is still unavailable. To further investigate the…”
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    Predicting developmental toxicity through toxicogenomics by Daston, George P., Naciff, Jorge M.

    “…Global analysis of gene expression in target cells or tissues in response to a toxicant holds significant promise for predictive toxicology. Toxicants elicit a…”
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    Gene Expression Profile Induced by 17α-Ethynyl Estradiol, Bisphenol A, and Genistein in the Developing Female Reproductive System of the Rat by Naciff, Jorge M., Jump, M. Lynn, Torontali, Suzanne M., Carr, Gregory J., Tiesman, Jay P., Overmann, Gary J., Daston, George P.

    Published in Toxicological sciences (01-07-2002)
    “…Exposure to some compounds with estrogenic activity, during fetal development, has been shown to alter development of reproductive organs, leading to abnormal…”
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    Toxicogenomic Approach to Endocrine Disrupters: Identification of a Transcript Profile Characteristic of Chemicals with Estrogenic Activity by Naciff, Jorge M., Daston, George P.

    Published in Toxicologic pathology (01-07-2004)
    “…Public concerns have been raised in recent years over the possible adverse effects that may result from exposure to chemicals in the environment that have the…”
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